Histopathologic Findings of Olfactory Mucosa in COVID-19 Patients
Journal of Otorhinolaryngology and Facial Plastic Surgery,
Vol. 9 No. 1 (2023),
2 September 2023
,
Page 1-5
https://doi.org/10.22037/orlfps.v9i1.42792
Abstract
Background: Olfactory manifestations are common findings during the course of COVID-19, while exact physiopathology is not known
Aim: We review histological changes of the nasal olfactory mucosa in COVID-19 non-survivors who died in the ICU.
Methods: Sampling was done within 1 hour of death under direct vision. Specimens were taken medial to the middle turbinate in the cribriform area and embedded in paraffin blocks and stained by haematoxylin and eosin.
Results: The most frequent histologic finding was the infiltration of inflammatory cells mostly comprised of lymphocytes. Inflammatory infiltration of mucosa was seen in all 11 patients with ulceration in 9 cases and neuritis in 3 cases.
Conclusion: Inflammatory infiltration of olfactory mucosa may be associated with smell manifestations. Further histological studies will clarify the role of the nasal mucosa in the physiopathology of COVID-19 especially olfactory involvement.
- COVID19; Olfactory; Histopathologic; Case report.
How to Cite
References
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