Chronic Noise Exposure Activates Apoptosis Signaling Pathway in the Rat Auditory Cortex
Journal of Otorhinolaryngology and Facial Plastic Surgery,
Vol. 5 No. 3 (2019),
23 March 2020
,
Page 1-5
https://doi.org/10.22037/orlfps.v5i3.29538
Abstract
Background: Today, hearing disorders are one of the most common problems in an industrial society. High-intensity sounds can induce apoptosis and metabolic changes in the auditory neural pathway and auditory cortex.
Aim: In this study, we investigated the effect of chronic noise exposure on Bax, Bcl-2 and Caspase-3 genes expression in the auditory cortex of rats.
Methods: Chronic exposure to 110 dB white noise was applied in male rats for 6 hours for 5 consecutive days. Superoxide dismutase (SOD) activity was measured in the serum of rats prior to and following noise exposure. Bax, Bcl-2 and Caspase-3 genes expression in the auditory cortex was determined by Real time PCR assay.
Results: Our results showed that the serum SOD level was significantly decreased in rats exposed to noise. In addition, the gene expression of Caspase-3 and Bax/Bcl-2 ratio was markedly increased in the auditory cortex of rats were subjected to chronic noise exposure compared to control rats.
Conclusion: Chronic noise exposure can activate apoptosis signaling pathway in the auditory cortex of rat.- Apoptosis
- Auditory Cortex
- Bax
- Bcl-2
- Caspase-3
- Chronic Noise Exposure.
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