Signaling Pathways Involved in Auditory Hair Cells Development
Journal of Otorhinolaryngology and Facial Plastic Surgery,
Vol. 3 No. 1 (2017),
16 August 2017
https://doi.org/10.22037/orlfps.v3i1.18238
Abstract
Auditory hair cells (HCs) cannot be spontaneously regenerated or replaced in mammalian damaged cochlea which leads to permanent deafness. On the other hand, regenerative ability of HCs in lower vertebrates such as birds and amphibians causes that researchers investigate underlying mechanisms and pathways which can possibly induce mammalian cochlear HCs regeneration and hearing recovery. Signaling cascades of HCs regeneration in lower vertebrate can be considered as the potential therapeutic option for the hearing loss in human. This paper reviews current knowledge about the main signaling pathways involved in HCs development in the mammalian cochlea.
- Signaling pathways
- Auditory Hair Cells
- Regeneration.
How to Cite
References
Ekdale, Eric G. "Form and function of the mammalian inner ear." Journal of anatomy 228, no. 2 (2016): 324-337.
Raphael, Yehoash, and Richard A. Altschuler. "Structure and innervation of the cochlea." Brain research bulletin 60, no. 5 (2003): 397-422.
Peyvandi, A., & Roozbahany, N. A. (2013). Hearing loss in chronic renal failure patient undergoing hemodialysis. Indian Journal of Otolaryngology and Head & Neck Surgery, 65(3), 537-540.
Lu, Xiaoling, Yilai Shu, Mingliang Tang, and Huawei Li. "Mammalian Cochlear Hair Cell Regeneration and Ribbon Synapse Reformation." Neural plasticity 2016 (2016).
White, Patricia M., Angelika Doetzlhofer, Yun Shain Lee, Andrew K. Groves, and Neil Segil. "Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells." Nature 441, no. 7096 (2006): 984.
Malgrange, Brigitte, Marc Thiry, Thomas R. Van De Water, Laurent Nguyen, Gustave Moonen, and P. P. Lefebvre. "Epithelial supporting cells can differentiate into outer hair cells and Deiters' cells in the cultured organ of Corti." Cellular and molecular life sciences 59, no. 10 (2002): 1744-1757.
Cox, Brandon C., Renjie Chai, Anne Lenoir, Zhiyong Liu, LingLi Zhang, Duc-Huy Nguyen, Kavita Chalasani et al. "Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo." Development 141, no. 4 (2014): 816-829.
Chonko, Kurt T., Israt Jahan, Jennifer Stone, Margaret C. Wright, Tomoyuki Fujiyama, Mikio Hoshino, Bernd Fritzsch, and Stephen M. Maricich. "Atoh1 directs hair cell differentiation and survival in the late embryonic mouse inner ear." Developmental biology 381, no. 2 (2013): 401-410.
Chai, Renjie, Bryan Kuo, Tian Wang, Eric J. Liaw, Anping Xia, Taha A. Jan, Zhiyong Liu et al. "Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea." Proceedings of the National Academy of Sciences 109, no. 21 (2012): 8167-8172.
Li, Wenyan, Jingfang Wu, Jianming Yang, Shan Sun, Renjie Chai, Zheng-Yi Chen, and Huawei Li. "Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway." Proceedings of the National Academy of Sciences 112, no. 1 (2015): 166-171.
Pickles, J. O. "The expression of fibroblast growth factors and their receptors in the embryonic and neonatal mouse inner ear." Hearing research 155, no. 1 (2001): 54-62.
Żak, Magdalena, Sjaak FL Klis, and Wilko Grolman. "The Wnt and Notch signalling pathways in the developing cochlea: formation of hair cells and induction of regenerative potential." International journal of developmental neuroscience 47 (2015): 247-258.
Chen, Ping, Jane E. Johnson, Huda Y. Zoghbi, and Neil Segil. "The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination." Development 129, no. 10 (2002): 2495-2505.
Kelly, Michael C., Qing Chang, Alex Pan, Xi Lin, and Ping Chen. "Atoh1 directs the formation of sensory mosaics and induces cell proliferation in the postnatal mammalian cochlea in vivo." Journal of Neuroscience 32, no. 19 (2012): 6699-6710.
Shou, Jianyong, J. Lisa Zheng, and Wei-Qiang Gao. "Robust generation of new hair cells in the mature mammalian inner ear by adenoviral expression of Hath1." Molecular and Cellular Neuroscience 23, no. 2 (2003): 169-179.
Yang, Juanmei, Ning Cong, Zhao Han, Yibo Huang, and Fanglu Chi. "Ectopic hair cell-like cell induction by Math1 mainly involves direct transdifferentiation in neonatal mammalian cochlea." Neuroscience letters 549 (2013): 7-11.
Kawamoto, Kohei, Shin-Ichi Ishimoto, Ryosei Minoda, Douglas E. Brough, and Yehoash Raphael. "Math1 gene transfer generates new cochlear hair cells in mature guinea pigs in vivo." Journal of Neuroscience 23, no. 11 (2003): 4395-4400.
Liu, Zhiyong, et al. "Age-dependent in vivo conversion of mouse cochlear pillar and Deiters' cells to immature hair cells by Atoh1 ectopic expression." Journal of Neuroscience 32.19 (2012): 6600-6610.
Atkinson, Patrick J., Andrew K. Wise, Brianna O. Flynn, Bryony A. Nayagam, and Rachael T. Richardson. "Hair cell regeneration after ATOH1 gene therapy in the cochlea of profoundly deaf adult guinea pigs." PloS one 9, no. 7 (2014): e102077.
Logan, Catriona Y., and Roel Nusse. "The Wnt signaling pathway in development and disease." Annu. Rev. Cell Dev. Biol. 20 (2004): 781-810.
Jacques, Bonnie E., Chandrakala Puligilla, Rachel M. Weichert, Anna Ferrer-Vaquer, Anna-Katerina Hadjantonakis, Matthew W. Kelley, and Alain Dabdoub. "A dual function for canonical Wnt/β-catenin signaling in the developing mammalian cochlea." Development 139, no. 23 (2012): 4395-4404.
Shi, Fuxin, Lingxiang Hu, Bonnie E. Jacques, Joanna F. Mulvaney, Alain Dabdoub, and Albert SB Edge. "β-Catenin is required for hair-cell differentiation in the cochlea." Journal of Neuroscience 34, no. 19 (2014): 6470-6479.
Shi, Fuxin, Lingxiang Hu, and Albert SB Edge. "Generation of hair cells in neonatal mice by β-catenin overexpression in Lgr5-positive cochlear progenitors." Proceedings of the National Academy of Sciences 110, no. 34 (2013): 13851-13856.
Chai, Renjie, Bryan Kuo, Tian Wang, Eric J. Liaw, Anping Xia, Taha A. Jan, Zhiyong Liu et al. "Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea." Proceedings of the National Academy of Sciences 109, no. 21 (2012): 8167-8172.
Waqas, Muhammad, Shasha Zhang, Zuhong He, Mingliang Tang, and Renjie Chai. "Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea." Frontiers of medicine 10, no. 3 (2016): 237-249.
Litingtung, Ying, and Chin Chiang. "Control of Shh activity and signaling in the neural tube." Developmental Dynamics 219, no. 2 (2000): 143-154.
Hardcastle, Zoë, Rong Mo, C. C. Hui, and Paul T. Sharpe. "The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants." Development 125, no. 15 (1998): 2803-2811.
Bellusci, Savério, Yasuhide Furuta, Margaret G. Rush, Randall Henderson, Glenn Winnier, and B. L. Hogan. "Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis." Development 124, no. 1 (1997): 53-63.
Lu, Na, Yan Chen, Zhengmin Wang, Guoling Chen, Qin Lin, Zheng-Yi Chen, and Huawei Li. "Sonic hedgehog initiates cochlear hair cell regeneration through downregulation of retinoblastoma protein." Biochemical and biophysical research communications 430, no. 2 (2013): 700-705.
Eswarakumar, V. P., I. Lax, and J. Schlessinger. "Cellular signaling by fibroblast growth factor receptors." Cytokine & growth factor reviews 16, no. 2 (2005): 139-149.
Hébert, Jean M. "FGFs: neurodevelopment’s Jack-of-all-trades–how do they do it?." Frontiers in neuroscience 5 (2011).
Schimmang, Thomas. "Expression and functions of FGF ligands during early otic development." International Journal of Developmental Biology 51, no. 6-7 (2007): 473-481.
Hayashi, Toshinori, Catherine A. Ray, and Olivia Bermingham-McDonogh. "Fgf20 is required for sensory epithelial specification in the developing cochlea." Journal of Neuroscience 28, no. 23 (2008): 5991-5999.
Pirvola, Ulla, Jukka Ylikoski, Ras Trokovic, Jean M. Hébert, Susan K. McConnell, and Juha Partanen. "FGFR1 is required for the development of the auditory sensory epithelium." Neuron 35, no. 4 (2002): 671-680.
Su, Yi-Xun, Cong-Cong Hou, and Wan-Xi Yang. "Control of hair cell development by molecular pathways involving Atoh1, Hes1 and Hes5." Gene 558, no. 1 (2015): 6-24.
Yamamoto, Norio, Kenji Tanigaki, Masayuki Tsuji, Daisuke Yabe, Juichi Ito, and Tasuku Honjo. "Inhibition of Notch/RBP-J signaling induces hair cell formation in neonate mouse cochleas." Journal of molecular medicine 84, no. 1 (2006): 37-45.
Lewis, Julian. "Notch signalling and the control of cell fate choices in vertebrates." In Seminars in cell & developmental biology, vol. 9, no. 6, pp. 583-589. Academic Press, 1998.
Daudet, Nicolas, and Julian Lewis. "Two contrasting roles for Notch activity in chick inner ear development: specification of prosensory patches and lateral inhibition of hair-cell differentiation." Development 132, no. 3 (2005): 541-551.
Lanford, Pamela J., Yu Lan, Rulang Jiang, Claire Lindsell, Gerry Weinmaster, Thomas Gridley, and Matthew W. Kelley. "Notch signalling pathway mediates hair cell development in mammalian cochlea." Nature genetics 21, no. 3 (1999).
Ma, Eva Y., Edwin W. Rubel, and David W. Raible. "Notch signaling regulates the extent of hair cell regeneration in the zebrafish lateral line." Journal of Neuroscience 28, no. 9 (2008): 2261-2273.
Pan, Wei, Ying Jin, Jing Chen, Robbert J. Rottier, Karen P. Steel, and Amy E. Kiernan. "Ectopic expression of activated notch or SOX2 reveals similar and unique roles in the development of the sensory cell progenitors in the mammalian inner ear." Journal of Neuroscience 33, no. 41 (2013): 16146-16157.
- Abstract Viewed: 899 times
- PDF Downloaded: 376 times