Approaches of auditory hair cells induction from stem cells
Journal of Otorhinolaryngology and Facial Plastic Surgery,
Vol. 3 No. 1 (2017),
16 August 2017
https://doi.org/10.22037/orlfps.v3i1.18237
Abstract
Hair cells are the sensory epithelial cells of both the auditory and the vestibular systems in the inner ear of all vertebrates. Auditory hair cells are located in the organ of corti on a thin layer of basement membrane in the cochlea of the inner ear. Damage to hair cells decreases hearing sensitivity. When these delicate hair cells in the cochlea are damaged, sound signals cannot be sent to the brain. In general, damage to the mammalian inner ear, is not returnable. In fact, a key goal in the treatment of sensorineural hearing loss is to find appropriate procedures to replace the missing hair cells. Cell therapy is one of the treatment options for hearing loss. In this regard, studies focus on ways which hair cells can be provided from exogenous and endogenous stem cells. This review identified ways to induce auditory hair cells regeneration from stem cells as the potential therapeutic approaches for the hearing loss.- Cell therapy
- Hair cell induction approaches
- Inner ear
- Differentiation
How to Cite
References
Dallos, Peter. "The active cochlea." Journal of Neuroscience 12 (1992): 4575-4575.
Peyvandi, A., & Roozbahany, N. A. (2013). Hearing loss in chronic renal failure patient undergoing hemodialysis. Indian Journal of Otolaryngology and Head & Neck Surgery, 65(3), 537-540
Appler, J.M. and Goodrich, L.V., 2011. Connecting the ear to the brain: molecular mechanisms of auditory circuit assembly. Progress in neurobiology, 93(4), pp.488-508.
Nadol Jr, J.B., Young, Y.S. and Glynn, R.J., 1989. Survival of spiral ganglion cells in profound sensorineural hearing loss: implications for cochlear implantation. Annals of Otology, Rhinology & Laryngology, 98(6), pp.411-416.
Rubel, E.W., Furrer, S.A. and Stone, J.S., 2013. A brief history of hair cell regeneration research and speculations on the future. Hearing research, 297, pp.42-51.
Fujioka, M., Okano, H. and Edge, A.S., 2015. Manipulating cell fate in the cochlea: a feasible therapy for hearing loss. Trends in neurosciences, 38(3), pp.139-144.
Roozbahany, N.A. and Niknazar, S., 2016. Cell Therapy Development in Hearing Loss. Journal of Hearing Sciences and Otolaryngology, 2(2), pp.51-56.
Lagarde, M.M.M., Wan, G., Zhang, L., Gigliello, A.R., McInnis, J.J., Zhang, Y., Bergles, D., Zuo, J. and Corfas, G., 2014. Spontaneous regeneration of cochlear supporting cells after neonatal ablation ensures hearing in the adult mouse. Proceedings of the National Academy of Sciences, 111(47), pp.16919-16924.
Parker, M.A., 2011. Biotechnology in the treatment of sensorineural hearing loss: foundations and future of hair cell regeneration. Journal of Speech, Language, and Hearing Research, 54(6), pp.1709-1731.
White, P.M., Doetzlhofer, A., Lee, Y.S., Groves, A.K. and Segil, N., 2006. Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells. Nature, 441(7096), pp.984-987.
Yoon, H., Lee, D.J., Kim, M.H. and Bok, J., 2011. Identification of genes concordantly expressed with Atoh1 during inner ear development. Anatomy & cell biology, 44(1), pp.69-78.
Gubbels, S.P., Woessner, D.W., Mitchell, J.C., Ricci, A.J. and Brigande, J.V., 2008. Functional auditory hair cells produced in the mammalian cochlea by in utero gene transfer. Nature, 455(7212), pp.537-541.
Woods, C., Montcouquiol, M. and Kelley, M.W., 2004. Math1 regulates development of the sensory epithelium in the mammalian cochlea. Nature neuroscience, 7(12), pp.1310-1318.
Fritzsch, B., Silos-Santiago, I., Bianchi, L.M. and Farinas, I., 1997. The role of neurotrophic factors in regulating the development of inner ear innervation. Trends in neurosciences, 20(4), pp.159-164.
Fritzsch, B., Tessarollo, L., Coppola, E. and Reichardt, L.F., 2004. Neurotrophins in the ear: their roles in sensory neuron survival and fiber guidance. Progress in brain research, 146, pp.265-278.
Fariñas, I., Jones, K.R., Tessarollo, L., Vigers, A.J., Huang, E., Kirstein, M., De Caprona, D.C., Coppola, V., Backus, C., Reichardt, L.F. and Fritzsch, B., 2001. Spatial shaping of cochlear innervation by temporally regulated neurotrophin expression. Journal of Neuroscience, 21(16), pp.6170-6180.
Gillespie, L.N. and Shepherd, R.K., 2005. Clinical application of neurotrophic factors: the potential for primary auditory neuron protection. European Journal of Neuroscience, 22(9), pp.2123-2133.
Schecterson, Leslayann C., and Mark Bothwell. "Neurotrophin and neurotrophin receptor mRNA expression in developing inner ear." Hearing research 73.1 (1994): 92-100
Wheeler, E.F., Bothwell, M., Schecterson, L.C. and von Bartheld, C.S., 1994. Expression of BDNF and NT-3 mRNA in hair cells of the organ of Corti: quantitative analysis in developing rats. Hearing research, 73(1), pp.46-56.
Landry, T.G., Wise, A.K., Fallon, J.B. and Shepherd, R.K., 2011. Spiral ganglion neuron survival and function in the deafened cochlea following chronic neurotrophic treatment. Hearing research, 282(1), pp.303-313.
Joyce, N., Annett, G., Wirthlin, L., Olson, S., Bauer, G. and Nolta, J.A., 2010. Mesenchymal stem cells for the treatment of neurodegenerative disease. Regenerative medicine, 5(6), pp.933-946.
Hunt, C.J., 2011. Cryopreservation of human stem cells for clinical application: a review. Transfusion Medicine and Hemotherapy, 38(2), pp.107-123.
Chen, W., Jongkamonwiwat, N., Abbas, L., Eshtan, S.J., Johnson, S.L., Kuhn, S., Milo, M., Thurlow, J.K., Andrews, P.W., Marcotti, W. and Moore, H.D., 2012. Restoration of auditory evoked responses by human ES-cell-derived otic progenitors. Nature, 490(7419), pp.278-282
Okano, T. and Kelley, M.W., 2012. Stem cell therapy for the inner ear: recent advances and future directions. Trends in amplification, 16(1), pp.4-18.
Pettingill, L.N., Wise, A.K., Geaney, M.S. and Shepherd, R.K., 2011. Enhanced auditory neuron survival following cell-based BDNF treatment in the deaf guinea pig. PloS one, 6(4), p.e18733.
Staecker, H., Kopke, R., Malgrange, B., Lefebvre, P. and Van De Water, T.R., 1996. NT-3 and/or BDNF therapy prevents loss of auditory neurons following loss of hair cells. Neuroreport, 7(4), pp.889-894.
. Chen, W., Cacciabue-Rivolta, D.I., Moore, H.D. and Rivolta, M.N., 2007. The human fetal cochlea can be a source for auditory progenitors/stem cells isolation. Hearing research, 233(1), pp.23-29.
Chen, W., Johnson, S.L., Marcotti, W., Andrews, P.W., Moore, H.D. and Rivolta, M.N., 2009. Human fetal auditory stem cells can be expanded in vitro and differentiate into functional auditory neurons and hair cell‐like cells. Stem Cells, 27(5), pp.1196-1204.
Shinohara, T., Bredberg, G., Ulfendahl, M., Pyykkö, I., Olivius, N.P., Kaksonen, R., Lindström, B., Altschuler, R. and Miller, J.M., 2002. Neurotrophic factor intervention restores auditory function in deafened animals. Proceedings of the National Academy of Sciences, 99(3), pp.1657-1660.
Fransson, A., Maruyama, J., Miller, J.M. and Ulfendahl, M., 2010. Post-treatment effects of local GDNF administration to the inner ears of deafened guinea pigs. Journal of neurotrauma, 27(9), pp.1745-1751.
Maruyama, J., Miller, J.M. and Ulfendahl, M., 2008. Glial cell line-derived neurotrophic factor and antioxidants preserve the electrical responsiveness of the spiral ganglion neurons after experimentally induced deafness. Neurobiology of disease, 29(1), pp.14-21.
Coleman, B., Fallon, J.B., Pettingill, L.N., De Silva, M.G. and Shepherd, R.K., 2007. Auditory hair cell explant co-cultures promote the differentiation of stem cells into bipolar neurons. Experimental cell research, 313(2), pp.232-243.
Hu, Z. and Ulfendahl, M., 2013. The potential of stem cells for the restoration of auditory function in humans. Regenerative medicine, 8(3), pp.309-318.
Taura, A., Ohnishi, H., Ochi, S., Ebisu, F., Nakagawa, T. and Ito, J., 2014. Effects of mouse utricle stromal tissues on hair cell induction from induced pluripotent stem cells. BMC neuroscience, 15(1), p.121.
Nayagam, B.A., Edge, A.S., Needham, K., Hyakumura, T., Leung, J., Nayagam, D.A. and Dottori, M., 2012. An in vitro model of developmental synaptogenesis using cocultures of human neural progenitors and cochlear explants. Stem cells and development, 22(6), pp.901-912.
Shi, F., Corrales, C.E., Liberman, M.C. and Edge, A.S., 2007. BMP4 induction of sensory neurons from human embryonic stem cells and reinnervation of sensory epithelium. European Journal of Neuroscience, 26(11), pp.3016-3023.
Matsumoto, M., Nakagawa, T., Higashi, T., Kim, T.S., Kojima, K., Kita, T., Sakamoto, T. and Ito, J., 2005. Innervation of stem cell-derived neurons into auditory epithelia of mice. Neuroreport, 16(8), pp.787-790.
Matsumoto, M., Nakagawa, T., Kojima, K., Sakamoto, T., Fujiyama, F. and Ito, J., 2008. Potential of embryonic stem cell‐derived neurons for synapse formation with auditory hair cells. Journal of neuroscience research, 86(14), pp.3075-3085.
Gunewardene, N., Crombie, D., Dottori, M. and Nayagam, B.A., 2016. Innervation of Cochlear Hair Cells by Human Induced Pluripotent Stem Cell-Derived Neurons In Vitro. Stem cells international, 2016.
Zheng, J.L. and Gao, W.Q., 2000. Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears. Nature neuroscience, 3(6), pp.580-586.
Kawamoto, K., Ishimoto, S.I., Minoda, R., Brough, D.E. and Raphael, Y., 2003. Math1 gene transfer generates new cochlear hair cells in mature guinea pigs in vivo. Journal of Neuroscience, 23(11), pp.4395-4400.
Liu, J.J., Shin, J.H., Hyrc, K.L., Liu, S., Lei, D., Holley, M.C. and Bao, J., 2006. Stem cell therapy for hearing loss: Math1 overexpression in VOT-E36 cells. Otology & Neurotology, 27(3), pp.414-421.
Han, Z., Yang, J.M., Chi, F.L., Cong, N., Huang, Y.B., Gao, Z. and Li, W., 2010. Survival and fate of transplanted embryonic neural stem cells by Atoh1 gene transfer in guinea pigs cochlea. Neuroreport, 21(7), pp.490-496.
Yang, J., Cong, N., Han, Z., Huang, Y. and Chi, F., 2013. Ectopic hair cell-like cell induction by Math1 mainly involves direct transdifferentiation in neonatal mammalian cochlea. Neuroscience letters, 549, pp.7-11.
Hu, Z., Wei, D., Johansson, C.B., Holmström, N., Duan, M., Frisén, J. and Ulfendahl, M., 2005. Survival and neural differentiation of adult neural stem cells transplanted into the mature inner ear. Experimental cell research, 302(1), pp.40-4
- Abstract Viewed: 944 times
- PDF Downloaded: 416 times