The Effect of Treatment with an Herbal Formulation of Salvia hydrangea, Citrus aurantium, Lipia citriodora, and Elm Bark on the Intensity of Tinnitus: A Clinical Trial
Journal of Otorhinolaryngology and Facial Plastic Surgery,
Vol. 5 No. 1 (2019),
22 September 2019
,
Page 1-6
https://doi.org/10.22037/orlfps.v5i1.12998
Abstract
Background: Tinnitus is a symptom of an underlying medical condition that is associated with hearing loss in humans. It is a subjective disease where patients hear voices that others cannot hear. Increase in noise pollution, growing development of communication devices, and the long-ranging 8-year war in our country have further accelerated the spread of this disorder. Given that no definitive medical or surgical treatment has been confirmed for this condition, new research to improve treatment options is urgent.
Aim: The purpose of this study was to assess the effect of a formulation prepared from Salvia hydrangea, Citrus aurantium, Lipia Citriodora, and elm bark on the status of tinnitus.
Methods: In this single-blind clinical trial, 144 patients with tinnitus were selected based on pre-defined inclusion criteria and then randomly divided into 3 groups: herbal formulation, cinnarizine, and placebo groups, where the frequency and intensity of tinnitus was measured based on the Tinnitus Handicap Inventory (THI) and Visual Analogue Scale (VAS) criteria before and on 28 and 56 days post treatment. Data were analyzed by the statistical software SPSS version 16, repeated measurement, one-way, and X2 for comparison within and among groups, with the significance level set at p < 0.05.
Results: comparably, tinnitus based on THI criteria differed among the 3 groups on 28 and 56 days of intervention, where the difference was statistically significant (p < 0.05). This difference was more significant between the cinnarizine and placebo groups. The mean severity of tinnitus, based on the VAS score, differed among the three groups on 28 and 56 days after intervention, although the difference was not statistically significant.
Conclusion: Herbal formulation was effective on tinnitus alleviation, but its effect was not superior to that of conventionally used chemical drug cinnarizine.- Cinnarizine
- Herbal Formulations
- THI Criteria Tinnitus
How to Cite
References
Paul J A, MCA. Cochlear Implants: Auditory Prostheses And Electric Hearing. New York: Springer; 2004.
Smeltzer S, B Brenda J, Janis L, G. K. Medical Surgical Nursing. 2 Ed. Tehran: Salemi- Jameanegar Publication; 2010.
Byung In Han, Ho Won Lee, Tae You Kim, Jun Seong Lim, Kyoung Sik Shin. Tinnitus: Characteristics, Causes, Mechanisms, and Treatments. J Clin Neurol. 2009 Mar;5(1):11–9.
Madani S, K. M. Evaluation Tinnitus Characteristics Of Patients In Sarry Avicenna Hospital ENT Clinic 1377. Sci J Mazandaran Univ Med Sci 2001;11(32):15-77.
Heller AS. Classification And Epidemiology Of Tinnitus. Otolaryngol Clin North Am 2003;36(2):239-48.
Enrico P, Sirca D, M. M. Antioxidants, Minerals, Vitamins, And Herbal Remedies In Tinnitus Therapy. Tinnitus: Pathophysiol Treat 2007;166: 323-30.
Emami F, Farahani F, Behnood F, M. G. Comparison Of Digital And Analogue Behind The Ear Hearing Aids Effectiveness In Treatment Of Tinnitus In Elderly Patients Of Otolaryngology Centers In Hamadan. Sci J Hamedan Univ Med Sci 2007;15(4).
Craig W. Martin. Tinnitus Retraining Therapy. Tinnitus. 2004:556-8.
Gardiner P, Kemper KJ. Herbs in Pediatric and Adolescent Medicine. Pediatr Rev 2000;21 (2):44-57.
Steele T; Rogers C J; Jacob SE. Herbal Remedies for Psoriasis: What Are Our Patients Taking?. Dermatol Nurs 2007;19(5):457-63.
Newman CW, Jacobson GP, Spitzer JB. Development Of The Tinnitus Handicap Inventory. Arch Otolaryngol Head Neck Surg. 1996;122(2):143-8.
Afshin-Majd S, Yarmohamadi ME, Izadi P, Shahbeigi S, Davati A. A comparison of gabapentin and placebo in the treatment of subjective tinnitus. Iran J Neurol. 2008;7(21):153-9.
Kim NK, Lee DH, Lee JH, Oh YL, Yoon IH, Seo ES, et al. Bojungikgitang and banhabaekchulchonmatang in adult patients with tinnitus, a randomized, double-blind, three-arm, placebo-controlled trial--study protocol. Trials 2010;28;11:34.
Rejali D, Sivakumar A, N. B. Ginkgo Biloba Does Not Benefit Patients With Tinnitus: A Randomized Placebo‐Controlled Double‐Blind Trial And Meta‐Analysis Of Randomized Trials. Clinical Otolaryngology & Allied Sciences. 2004;29(3):226-31.
Okhovat A, Berjis N, Okhovat H, Malekpour A, H. A. Low-Level Laser For Treatment Of Tinnitus: A Self-Controlled Clinical Trial. Journal Of Research In Medical Sciences: The Official Journal Of Isfahan University Of Medical Sciences. 2011;16(1):33.
- Abstract Viewed: 254 times
- PDF Downloaded: 404 times