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Differential diagnosis of tuberculosis, sarcoidosis, and anthracosis by CD8, CD3, and CD4 levels by flow-cytometry

Nazanin Akbarifazli, Atefeh Abedini, Esmail Mortaz




Background: Determination of a desirable diagnostic tests is an issue of importance especially to differentiate between tuberculosis) TB(, sarcoidosis, and anthracosis. The purpose of the present study was to determine the differential diagnosis of tuberculosis, sarcoidosis and anthracosis with CD8, CD3, and CD4 by flow-cytometry.
Materials and Methods: In this descriptive cross-sectional comparative survey, 40 consecutive patients attending to Masih Daneshvari Hospital in Tehran were enrolled and CD4/CD8 ratio, CD8, CD3, and CD4 were determined by flow-cytometry and compared across patients with three diseases including tuberculosis, sarcoidosis, and anthracosis.
Results: The results demonstrated that CD4 was significantly higher in anthracosis cases (P<0.007) and the CD8 was significantly higher in patients with TB (P<0.008).
Conclusion: It was attained ultimately that CD4 and CD8 levels could be a desirable diagnostic markers for anthracosis and TB, respectively.


Flow-Cytometry; Tuberculosis; Sarcoidosis; Anthracosis; Broncho alveolar lavage (BAL)


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DOI: https://doi.org/10.22037/smsj.v1i1.23043


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