Harvesting Tissue from Teeth-related Structures as a Source of Stem Cells Teeth related stem cells
Journal of "Regeneration, Reconstruction & Restoration" (Triple R),
Vol. 6 (2021),
13 March 2021
,
Page e2
https://doi.org/10.22037/rrr.v6i.33483
Abstract
The tooth bud comprises of aggregation of cells demarcated as enamel organ, dental papilla, and dental follicle. They produce different parts of tooth and its supporting structures. More attention is paid to the teeth and its related structures as sources of mesenchymal stem cells (MSCs). Using dental sources has many advantages, such as easy access and less ethical consideration. MSCs from these tissues, besides In vitro achievements, showed effective results in clinical applications, especially in oral and maxillofacial regeneration. The case selection and how to harvest the tissue from teeth structures are rarely described. In this concise review, the criteria of subject and teeth selection as a source of MSC isolation were assessed and how to harvest the considered tissue was also discussed.
Keywords:
- Dental Pulp
- Periodontal Ligament
- Supporting Tooth Structure
- Stem Cell
How to Cite
Atarbashi-Moghadam, F. (2021). Harvesting Tissue from Teeth-related Structures as a Source of Stem Cells: Teeth related stem cells. Journal of "Regeneration, Reconstruction & Restoration" (Triple R), 6, e2. https://doi.org/10.22037/rrr.v6i.33483
References
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4. Yang X, Li L, Xiao L, Zhang D. Recycle the dental fairy’s package: Overview of dental pulp stem cells. Stem Cell Res Ther. 2018;9(1):1–8.
5. Cristaldi M, Mauceri R, Campisi G, Pizzo G, Alessandro R, Tomasello L, et al. Growth and Osteogenic Differentiation of Discarded Gingiva-Derived Mesenchymal Stem Cells on a Commercial Scaffold. Front Cell Dev Biol. 2020;8(May):1–16.
6. Zhou T, Pan J, Wu P, Huang R, Du W, Zhou Y, et al. Dental Follicle Cells: Roles in Development and beyond. Stem Cells Int. 2019;2019.
7. Shinagawa-Ohama R, Mochizuki M, Tamaki Y, Suda N, Nakahara T. Heterogeneous Human Periodontal Ligament-Committed Progenitor and Stem Cell Populations Exhibit a Unique Cementogenic Property under in Vitro and in Vivo Conditions. Stem Cells Dev. 2017;26(9):632–45.
8. Pignatari GC EM. The Use of SHED in Cellular Therapy and Disease Modeling. JBR J Interdiscip Med Dent Sci. 2014;02(05).
9. Trejo Iriarte CG, Ramírez Ramírez O, Muñoz García A, Verdín Terán SL, Gómez Clavel JF. Isolation of periodontal ligament stem cells from extracted premolars. Simplified method. Rev Odontológica Mex. 2017;21(1):e12–20.
10. Motamedian S, Tabatabaei F, Akhlaghi F, Torshabi M, Gholamin P, Khojasteh A. Response of Dental Pulp Stem Cells to Synthetic, Allograft, and Xenograft Bone Scaffolds. Int J Periodontics Restorative Dent. 2017;37(1):47–59.
11. Khoshhal M, Amiri I, Gholami L. Comparison of in vitro properties of periodontal ligament stem cells derived from permanent and deciduous teeth. J Dent Res Dent Clin Dent Prospects. 2017;11(3):140–8.
12. Yildirim S. Dental Pulp Stem Cells. 1st ed. Springer; 2013.
13. Demarco, FF; Conde M, Cavalcanti, B; Casagrande, L; Sakai VNJ. dental pulp tissue engineering. Braz Dent J. 2011;22(1):3–13.
14. Hossein-khannazer N, Hashemi SM, Namaki S, Ghanbarian H, Sattari M, Khojasteh A. Study of the immunomodulatory effects of osteogenic differentiated human dental pulp stem cells. Life Sci. 2019; 216:111–8.
15. Samiei, M; Aghazadeh, M; Movassaghpour, AA; Fallah, A; Asl Aminabadi, N; Vahid Pakdel, SM; Sakhinia E, Asghari Estiar, M; Omidi, Y; Pakdel F. Isolation and Characterization of Dental Pulp Stem Cells from Primary and Permanent Teeth. J Am Sci. 2013;9(12).
16. Liang Z, Kawano S, Chen W, Sadrkhani MS, Lee C, Kim E, et al. Minced Pulp as Source of Pulpal Mesenchymal Stem Cells with Odontogenic Differentiation Capacity. J Endod. 2018;44(1):80–6.
17. Soheilifar S, Amiri I, Bidgoli M, Hedayatipanah M. Comparison of Periodontal Ligament Stem Cells Isolated from the Periodontium of Healthy Teeth and Periodontitis-Affected Teeth. J Dent (Tehran). 2016;13(4):271–8.
18. Kim K, Yi T, Yun J-H. Maintained Stemness of Human Periodontal Ligament Stem Cells Isolated After Prolonged Storage of Extracted Teeth. J Periodontol. 2016;87(7):e148–58.
19. Wang L, Shen H, Zheng W, Tang L, Yang Z, Gao Y, et al. Characterization of stem cells from alveolar periodontal ligament. Tissue Eng - Part A. 2011;17(7–8):1015–26.
20. Song JS, Kim SO, Kim SH, Choi HJ, Son HK, Jung HS, et al. In vitro and in vivo characteristics of stem cells derived from the periodontal ligament of human deciduous and permanent teeth. Tissue Eng - Part A. 2012;18(19–20):2040–51.
21. Honda MJ, Imaizumi M, Tsuchiya S, Morsczeck C. Dental follicle stem cells and tissue engineering. J Oral Sci. 2010;52(4):541–52.
22. Haghanifar S, Moudi E, Seyedmajidi M, Mehdizadeh M, Nosrati K, Abbaszadeh N, et al. Can the Follicle-Crown Ratio of the Impacted Third Molars be a Reliable Indicator of Pathologic Problem? J Dent (Shiraz, Iran). 2014;15(4):187–91.
23. Cahill DR, Marks SC. Tooth eruption: evidence for the central role of the dental follicle. J Oral Pathol Med. 1980;9(4):189–200.
24. Morsczeck C, Götz W, Schierholz J, Zeilhofer F, Kühn U, Möhl C, et al. Isolation of precursor cells (PCs) from human dental follicle of wisdom teeth. Matrix Biol. 2005;24(2):155–65.
25. de Mello Palma V, Danesi CC, Arend CF, Venturini AB, Blaya DS, Neto MM, et al. Study of Pathological Changes in the Dental Follicle of Disease-Free Impacted Third Molars. J Maxillofac Oral Surg [Internet]. 2018;17(4):611–5.
26. Dongol A, Sagtani A, Jaisani MR, Singh A, Shrestha A, Pradhan A, et al. Dentigerous Cystic Changes in the Follicles Associated with Radiographically Normal Impacted Mandibular Third Molars. Int J Dent. 2018;2018:1–5.
27. Baykul T, Saglam AA, Aydin U, Başak K. Incidence of cystic changes in radiographically normal impacted lower third molar follicles. Oral Surgery, Oral Med Oral Pathol Oral Radiol Endodontology. 2005;99(5):542–5.
28. Huang GTJ, Sonoyama W, Liu Y, Liu H, Wang S, Shi S. The Hidden Treasure in Apical Papilla: The Potential Role in Pulp/Dentin Regeneration and BioRoot Engineering. J Endod. 2008;34(6):645–51.
29. Kang J, Fan W, Deng Q, He H, Huang F. Stem Cells from the Apical Papilla: A Promising Source for Stem Cell-Based Therapy. Biomed Res Int. 2019;2019.
30. Diao S, Lin X, Wang L, Dong R, Du J, Yang D, et al. Analysis of gene expression profiles between apical papilla tissues, stem cells from apical papilla and cell sheet to identify the key modulators in MSCs niche. Cell Prolif. 2017;50(3):1–9.
31. Nada OA, El Backly RM. Stem Cells From the Apical Papilla (SCAP) as a Tool for Endogenous Tissue Regeneration. Front Bioeng Biotechnol. 2018;6:103.
32. Abe S, Yamaguchi S, Amagasa T. Multilineage Cells from Apical Pulp of Human Tooth with Immature Apex. Oral Sci Int. 2007;4(1):45–58.
33. Grawish ME. Gingival-derived mesenchymal stem cells: An endless resource for regenerative dentistry. World J Stem Cells. 2018;10(9):116–8.
34. Fawzy El-Sayed KM, Dörfer CE. Gingival Mesenchymal Stem/Progenitor Cells: A Unique Tissue Engineering Gem. Stem Cells Int. 2016;2016.
35. Pereira LO, Rubini MR, Silva JR, Oliveira DM, Silva IC, Poças-Fonseca MJ AR. Comparison of stem cell properties of cells isolated from normal and inflamed dental pulps. Int Endod J. 2012;45(12):1080–90.
36. Alongi DJ, Yamaza T, Song Y, Fouad AF, Elaine E. Stem/progenitor cells from inflamed human dental pulp retain tissue regeneration potential. Regen Med. 2010;5(4):617–31.
37. Park JC, Kim JM, Jung IH, Kim JC, Choi SH, Cho KS, et al. Isolation and characterization of human periodontal ligament (PDL) stem cells (PDLSCs) from the inflamed PDL tissue: In vitro and in vivo evaluations. J Clin Periodontol. 2011;38(8):721–31.
2. Tomokiyo A, Yoshida S, Hamano S, Hasegawa D, Sugii H, Maeda H. Detection, characterization, and clinical application of mesenchymal stem cells in periodontal ligament tissue. Stem Cells Int. 2018;2018.
3. Avinash K, Malaippan S, Dooraiswamy JN. Methods of isolation and characterization of stem cells from different regions of oral cavity using markers: A systematic review. Int J Stem Cells. 2017;10(1):12–20.
4. Yang X, Li L, Xiao L, Zhang D. Recycle the dental fairy’s package: Overview of dental pulp stem cells. Stem Cell Res Ther. 2018;9(1):1–8.
5. Cristaldi M, Mauceri R, Campisi G, Pizzo G, Alessandro R, Tomasello L, et al. Growth and Osteogenic Differentiation of Discarded Gingiva-Derived Mesenchymal Stem Cells on a Commercial Scaffold. Front Cell Dev Biol. 2020;8(May):1–16.
6. Zhou T, Pan J, Wu P, Huang R, Du W, Zhou Y, et al. Dental Follicle Cells: Roles in Development and beyond. Stem Cells Int. 2019;2019.
7. Shinagawa-Ohama R, Mochizuki M, Tamaki Y, Suda N, Nakahara T. Heterogeneous Human Periodontal Ligament-Committed Progenitor and Stem Cell Populations Exhibit a Unique Cementogenic Property under in Vitro and in Vivo Conditions. Stem Cells Dev. 2017;26(9):632–45.
8. Pignatari GC EM. The Use of SHED in Cellular Therapy and Disease Modeling. JBR J Interdiscip Med Dent Sci. 2014;02(05).
9. Trejo Iriarte CG, Ramírez Ramírez O, Muñoz García A, Verdín Terán SL, Gómez Clavel JF. Isolation of periodontal ligament stem cells from extracted premolars. Simplified method. Rev Odontológica Mex. 2017;21(1):e12–20.
10. Motamedian S, Tabatabaei F, Akhlaghi F, Torshabi M, Gholamin P, Khojasteh A. Response of Dental Pulp Stem Cells to Synthetic, Allograft, and Xenograft Bone Scaffolds. Int J Periodontics Restorative Dent. 2017;37(1):47–59.
11. Khoshhal M, Amiri I, Gholami L. Comparison of in vitro properties of periodontal ligament stem cells derived from permanent and deciduous teeth. J Dent Res Dent Clin Dent Prospects. 2017;11(3):140–8.
12. Yildirim S. Dental Pulp Stem Cells. 1st ed. Springer; 2013.
13. Demarco, FF; Conde M, Cavalcanti, B; Casagrande, L; Sakai VNJ. dental pulp tissue engineering. Braz Dent J. 2011;22(1):3–13.
14. Hossein-khannazer N, Hashemi SM, Namaki S, Ghanbarian H, Sattari M, Khojasteh A. Study of the immunomodulatory effects of osteogenic differentiated human dental pulp stem cells. Life Sci. 2019; 216:111–8.
15. Samiei, M; Aghazadeh, M; Movassaghpour, AA; Fallah, A; Asl Aminabadi, N; Vahid Pakdel, SM; Sakhinia E, Asghari Estiar, M; Omidi, Y; Pakdel F. Isolation and Characterization of Dental Pulp Stem Cells from Primary and Permanent Teeth. J Am Sci. 2013;9(12).
16. Liang Z, Kawano S, Chen W, Sadrkhani MS, Lee C, Kim E, et al. Minced Pulp as Source of Pulpal Mesenchymal Stem Cells with Odontogenic Differentiation Capacity. J Endod. 2018;44(1):80–6.
17. Soheilifar S, Amiri I, Bidgoli M, Hedayatipanah M. Comparison of Periodontal Ligament Stem Cells Isolated from the Periodontium of Healthy Teeth and Periodontitis-Affected Teeth. J Dent (Tehran). 2016;13(4):271–8.
18. Kim K, Yi T, Yun J-H. Maintained Stemness of Human Periodontal Ligament Stem Cells Isolated After Prolonged Storage of Extracted Teeth. J Periodontol. 2016;87(7):e148–58.
19. Wang L, Shen H, Zheng W, Tang L, Yang Z, Gao Y, et al. Characterization of stem cells from alveolar periodontal ligament. Tissue Eng - Part A. 2011;17(7–8):1015–26.
20. Song JS, Kim SO, Kim SH, Choi HJ, Son HK, Jung HS, et al. In vitro and in vivo characteristics of stem cells derived from the periodontal ligament of human deciduous and permanent teeth. Tissue Eng - Part A. 2012;18(19–20):2040–51.
21. Honda MJ, Imaizumi M, Tsuchiya S, Morsczeck C. Dental follicle stem cells and tissue engineering. J Oral Sci. 2010;52(4):541–52.
22. Haghanifar S, Moudi E, Seyedmajidi M, Mehdizadeh M, Nosrati K, Abbaszadeh N, et al. Can the Follicle-Crown Ratio of the Impacted Third Molars be a Reliable Indicator of Pathologic Problem? J Dent (Shiraz, Iran). 2014;15(4):187–91.
23. Cahill DR, Marks SC. Tooth eruption: evidence for the central role of the dental follicle. J Oral Pathol Med. 1980;9(4):189–200.
24. Morsczeck C, Götz W, Schierholz J, Zeilhofer F, Kühn U, Möhl C, et al. Isolation of precursor cells (PCs) from human dental follicle of wisdom teeth. Matrix Biol. 2005;24(2):155–65.
25. de Mello Palma V, Danesi CC, Arend CF, Venturini AB, Blaya DS, Neto MM, et al. Study of Pathological Changes in the Dental Follicle of Disease-Free Impacted Third Molars. J Maxillofac Oral Surg [Internet]. 2018;17(4):611–5.
26. Dongol A, Sagtani A, Jaisani MR, Singh A, Shrestha A, Pradhan A, et al. Dentigerous Cystic Changes in the Follicles Associated with Radiographically Normal Impacted Mandibular Third Molars. Int J Dent. 2018;2018:1–5.
27. Baykul T, Saglam AA, Aydin U, Başak K. Incidence of cystic changes in radiographically normal impacted lower third molar follicles. Oral Surgery, Oral Med Oral Pathol Oral Radiol Endodontology. 2005;99(5):542–5.
28. Huang GTJ, Sonoyama W, Liu Y, Liu H, Wang S, Shi S. The Hidden Treasure in Apical Papilla: The Potential Role in Pulp/Dentin Regeneration and BioRoot Engineering. J Endod. 2008;34(6):645–51.
29. Kang J, Fan W, Deng Q, He H, Huang F. Stem Cells from the Apical Papilla: A Promising Source for Stem Cell-Based Therapy. Biomed Res Int. 2019;2019.
30. Diao S, Lin X, Wang L, Dong R, Du J, Yang D, et al. Analysis of gene expression profiles between apical papilla tissues, stem cells from apical papilla and cell sheet to identify the key modulators in MSCs niche. Cell Prolif. 2017;50(3):1–9.
31. Nada OA, El Backly RM. Stem Cells From the Apical Papilla (SCAP) as a Tool for Endogenous Tissue Regeneration. Front Bioeng Biotechnol. 2018;6:103.
32. Abe S, Yamaguchi S, Amagasa T. Multilineage Cells from Apical Pulp of Human Tooth with Immature Apex. Oral Sci Int. 2007;4(1):45–58.
33. Grawish ME. Gingival-derived mesenchymal stem cells: An endless resource for regenerative dentistry. World J Stem Cells. 2018;10(9):116–8.
34. Fawzy El-Sayed KM, Dörfer CE. Gingival Mesenchymal Stem/Progenitor Cells: A Unique Tissue Engineering Gem. Stem Cells Int. 2016;2016.
35. Pereira LO, Rubini MR, Silva JR, Oliveira DM, Silva IC, Poças-Fonseca MJ AR. Comparison of stem cell properties of cells isolated from normal and inflamed dental pulps. Int Endod J. 2012;45(12):1080–90.
36. Alongi DJ, Yamaza T, Song Y, Fouad AF, Elaine E. Stem/progenitor cells from inflamed human dental pulp retain tissue regeneration potential. Regen Med. 2010;5(4):617–31.
37. Park JC, Kim JM, Jung IH, Kim JC, Choi SH, Cho KS, et al. Isolation and characterization of human periodontal ligament (PDL) stem cells (PDLSCs) from the inflamed PDL tissue: In vitro and in vivo evaluations. J Clin Periodontol. 2011;38(8):721–31.
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