تعیین ﺑﺮوز آﺳﯿﺐ ﺣﺎد ﮐﻠﯿﻮی در ﺑﯿﻤﺎران ﮐﻮرﭘﻮﻟﻤﻮﻧﺎل ﻧﺎﺷﯽ از ﺑﯿﻤﺎری اﻧﺴﺪادی ﻣﺰﻣﻦ رﯾﻮی ﺗﺤﺖ درﻣﺎن ﺑﺎ دﯾﻮرﺗﯿﮏ در ﺑﯿﻤﺎرﺳﺘﺎن اﻣﺎم خمینی و بیمارستان گلستان اهواز در سال 1398 اثر دیورتیک درمانی در آﺳﯿﺐ ﺣﺎد ﮐﻠﯿﻮی در ﺑﯿﻤﺎران ﮐﻮرﭘﻮﻟﻤﻮﻧﺎل ﻧﺎﺷﯽ از ﺑﯿﻤﺎری اﻧﺴﺪادی ﻣﺰﻣﻦ رﯾﻮی
Nafas Journal,
Vol. 7 No. 3 (1399),
5 Azar 2020
Abstract
Background: The classic complication of cardiovascular disease is chronic obstructive pulmonary disease, which caused to coronary insufficiency due to the enlargement or hypertrophy of the right ventricle. Hypoxic pulmonary vasoconstriction, hypercapnia, and acidosis secondry to the chronic obstructive pulmonary disease (COPD) have been suggested as possible mechanisms of corpulmonella. Corpolmonel can cause peripheral and pulmonary edema, in which case diuretics help reduce symptoms and edema, but may also cause dehydration due to vascular volume reduction and systemic hypotension. this study was designed with the aim of determining the effect of diuretics drugs in acute kidney damage in corpolmonel patients secondry to chronic obstractive diseases.
Materials and Methods: In this cross-sectional descriptive study, a total of 69 subjects with corpolmonel secondry to chronic obstractive pulmonary diseases which were admitted to the internal medicine and ICU wards of Imam Khomeini and Golestan Hospital in Ahvaz in 1398 were included. Then the incidence of AKI and some related risk factors in this patients were determined. Patients who during the first 10 days of received diuretics showed more than 30% of their baseline serum cratenine were considered as acute kidney injury.
Results: Most patients were male (58%) and had a mean age of 67.5 years (age range 36 to 89 years). patients received intravenous injection (63.8%). the mean diuretic dose was 80 mg (range 20-240 mg). Out of a total of 69 patients with diuretic therapy, 13 subjects (18.8%) developed AKI. No significant relationship was found between age, sex, basal creatinine and received diuretic dose and AKI (P <0.05).
Conclusion: Based on our obtained results, it can be conculoded that the incidence of AKI in corpolmonale patients secondry to the chronic obstractive pulmonary disease can be sdecreased using diuretics.
- Chronic Obstractive Pulmonary Disease
- Corpolmonale
- Acute Kidney Injury
- Diuretics Drugs
How to Cite
References
2. A Systematic Review and Meta-analysis. Das SK, Choupoo NS, Saikia P, Lahkar A. Incidence Proportion of Acute Cor Pulmonale in Patients with Acute Respiratory Distress Syndrome Subjected to Lung Protective Ventilation: 6, s.l. : Indian Journal of Critical Care Medicine, 2017, Vol. 21, pp. 364-375. ISSN: 0972-5229.
3. Budev MM, Arroliga AC, Wiedemann HP, Matthay RA. Cor pulmonale: an overview. 3, s.l. : Thieme Medical Publishers, 2003, Seminars in Respiratory and Critical Care Medicine., Vol. 24, pp. 233-244. ISSN: 1069-3424.
4. MK, Han, et al Pulmonary diseases and the heart.. 25, s.l. : Circulation, 2007, Vol. 116, pp. 2992-3005. ISSN: 1524-4539.
5. Haddad F, et al. Incidence, correlates, and consequences of acute kidney injury in patients with pulmonary arterial hypertension hospitalized with acute right-side heart failure. 7, s.l. : Elsevier, 2011, Journal of Cardiac Failure, Vol. 17, pp. 533-539. ISSN: 1071-9164.
6. Mielniczuk LM, et al. 3, s.l. Worsening renal function and prognosis in pulmonary hypertension patients hospitalized for right heart failure. : Wiley Periodicals Inc., 2012, Congestive Heart Failure, Vol. 18, pp. 151-157. ISSN: 1751-7133.
7. Barakat MF, et al. Acute kidney injury in stable COPD and at exacerbation. 1, s.l. : Dove Press, 2015, International Journal of COPD, Vol. 10, pp. 20672077. ISSN: 1178-2005.
8. Li S, et al. Renal impairment in patients with chronic obstructive pulmonary disease: a retrospective observational study. 2, s.l. : International Journal of Clinical and Experimental Medicine, 2018, Vol. 11, pp. 1285-1290. ISSN: 1940-5901.
9. Mapel DW, Marton JP. Prevalence of renal and hepatobiliary disease, laboratory abnormalities, and potentially toxic medication exposures among persons with COPD. s.l. : Dove Press, 2013, International Journal of COPD, Vol. 8, pp. 127-134. ISSN: 1178-2005.
10. Alaithan AM, Memon JI, Rehmani RS, Qureshi AA, Salam A. Chronic obstructive pulmonary disease: hospital and intensive care unit outcomes in the Kingdom of Saudi Arabia. s.l. : Dove Press, 2012, International Journal of COPD, Vol. 7, pp. 819-823. ISSN: 1178-2005.
11. Fabbian F, et al Impact of renal dysfunction on in-hospital mortality of patients with severe chronic obstructive pulmonary disease: a single-center Italian study.. 7, s.l. : Springer Link, 2016, International Urology and Nephrology, Vol. 48, pp. 1121-1127. ISSN: 1573-2584.
12. Galiè N, et al. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension s.l. : European Respiratory Society, 2015, European Respiratory Journal, pp. ERJ-01032-2015--. ISSN: 1399-3003.
13. Steven D, Shapiro MD, Gordon L, Snider MD, Stephen I, Rennard M. Chronic Brobchitis and Emphysema . Murray, Nadel, Mason, broaddus. Text book of respiratory medicine. Philadelphia. Elsevier Saunders.2005.Vol2 4th ed: 1116-27.
14. Xin Wan ,Dawei Chen,Yan TanMengqing MaFeng ZhangZhihe LiuYue ChenWei ShaoChangchun Cao. Incidence, Risk Factors, and PrognostiImplications of Acute Kidney Injury in Patientswith Acute Exacerbation of COPD. International Journal of Chronic Obstructive Pulmonary Disease 2020:15 1085–1092
15. Iwagami, M., Mansfield, K., Quint, J. et al. Diagnosis of acute kidney injury and its association with in-hospital mortality in patients with infective exacerbations of bronchiectasis: cohort study from a UK nationwide database. BMC Pulm Med 16, 14 (2016). https://doi.org/10.1186/s12890-016-0177-5
16. Gaddam, S., Gunukula, S.K., Lohr, J.W. et al. Prevalence of chronic kidney disease in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. BMC Pulm Med 16, 158 (2016). https://doi.org/10.1186/s12890-016-0315-0
17. Chen CY, Liao KM. Chronic obstructive pulmonary disease is associated with risk of chronic kidney disease: a nationwide case-cohort study. Sci Rep. 2016;6:25855
18. Garcia-Olmos L, Alberquilla A, Ayala V, Garcia-Sagredo P, Morales L, Carmona M, et al. Comorbidity in patients with chronic obstructive pulmonary disease in family practice: a cross sectional study. BMC Fam Pract. 2013;14:11.
19. Incalzi RA, Corsonello A, Pedone C, Battaglia S, Paglino G, Bellia V. Chronic renal failure: a neglected comorbidity of COPD. Chest. 2010;137(4):831–7.
20. Nagorni-Obradovic LM, Vukovic DS. The prevalence of COPD comorbidities in Serbia: results of a national survey. NPJ Prim Care RespirMed. 2014;24:14008
- Abstract Viewed: 624 times