Transplant-Associated Thrombotic Microangiopathy (TA-TMA) in Childhood - A literature review
Journal of Pediatric Nephrology,
Vol. 3 No. 2 (2015),
2 May 2015
,
Page 42-48
https://doi.org/10.22037/jpn.v3i2.8407
Abstract
Transplant-associated thrombotic microangiopathy (TA-TMA) is considered one of the most severe complications after hematopoietic stem cell transplantation (HSCT). Transplant-associated thrombotic microangiopathy (TA-TMA) constitutes a form of microangiopathic haemolytic anemia and thrombocytopenia derived from a generalized endothelial dysfunction with intravascular platelet activation and formation of platelet-rich thrombi within the microcirculation. Since clinical features are common in several post hematopoietic stem cell transplantation (HSCT) complications such as capillary leak syndrome, engraftment syndrome, graft versus host disease (GVHD), diffuse alveolar hemorrhage and veno occlusive disease (VOD), an initial diagnosis of TA-TMA is not always certain, which is a principal reason for the failure of proposed treatments.
Keywords: Thrombotic Microangiopathies; Hematopoietic Stem Cell Transplantation; Child; Hemolytic-Uremic Syndrome; Eculizumab.How to Cite
References
John Chapin, Tsiporah Shore, Peter Forsberg, Garrett Desman, Koen Van Besien, Jeffrey Laurence. Hematopoietic Transplant-Associated Thrombotic Microangiopathy: Clinical Advances in Hematology & Oncology 2014;12(9):
Uderzo CC, Jodele S, Missiry ME, Ciceri F, Busca A, et al. (2014) Transplant-Associated Thrombotic Microangiopathy (TA-TMA) and Consensus Based Diagnostic and Therapeutic Recommendations: Which TA-TMA Patients to Treat and When?. J Bone Marrow Res 2:152. doi: 10.4172/2329-8820.1000152.
Sonata Jodele, Stella M. Davies, Adam Lane, Diagnostic and risk criteria for HSCT-associated thrombotic microangiopathy: a study in children and young adults. Blood.2014 124: 645-653.
Benjamin L. Laskin, Jens Goebel, Stella M. Davies and Sonata Jodele.Small vessels, big trouble in the kidneys and beyond: hematopoietic stem cell transplantation associated thrombotic microangiopathy. Blood. 2014 Jul 24; 124(4):645-53. doi: 10.1182/blood-2014-03-564997.
Fatih Erbey. Transplant-Associated Thrombotic Microangiopathy in Childhood edicalpark Bahcelievler Hospital, Department of Pediatric Hematology/Oncology & Pediatric BMT Unit, Istanbul. Available at: www.intechopen.com.
Eileen P. Smith .Hematologic Disorders after Solid Organ transplantation: American Society of Hematology. Hematology 2010: 281-286.
George J, Nester C. Syndromes of Thrombotic Microangiopathy. N Engl J Med. 2014; 371:654-666. doi: 10.1056/NEJMra1312353.
Buck M. Treatment of Hemolytic Uremic Syndrome with Eculizumab. [online] Available at: http://www.medicine.virginia.edu/clinical/departments/pediatrics/education/pharm-news/current/201202.pdf.
Jodele S, Fukuda T, Vinks A and Et al. Eculizumab Therapy in Children with Severe Hematopoietic Stem Cell Transplantation–Associated Thrombotic Microangiopathy. Biol Blood Marrow Transplant. 2014; 20(4):518-25. doi: 10.1016/j.bbmt.2013.12.565.
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