Renal Amyloidosis Due to Juvenile Rheumatoid Arthritis Occurring in Early Childhood
Journal of Pediatric Nephrology,
Vol. 3 No. 2 (2015),
2 May 2015
Renal amyloidosis is a late manifestation of chronic juvenile rheumatoid arthritis (JRA) and usually manifests during the first 10 to 15 years after the onset of JRA. We hereby report a boy with JRA-related renal amyloidosis who presented with nephrotic syndrome in early childhood. Amyloidosis was associated with a 6-year history of juvenile rheumatic arthritis (JRA). Diagnosis of renal amyloidosis was confirmed by the deposition of Congo red positive amyloid fibrils within the glomeruli. Polarized light microscopy showed the classic green birefringence appearance.Key words: Arthritis, Juvenile; Amyloidosis, familial renal; Child
How to Cite
Westermark P, Benson MD, Buxbaum JN, et al. A primer of amyloid nomenclature. Amyloid 2007; 14:179-183.
hmann HJ, Goodman HJ, Gilbertson JA, Gallimore JR, Sabin CA, Gillmore JD, et al. Natural history and outcome in systemic AA amyloidosis. N Engl J Med 2007; 356:2361-71.
Khalighi MA, Wallace WD, Palma-Diaz MF. Amyloid nephropathy. Clin Kidney J 2014;7:97-106.
Dember L. Amyloidosis-associated kidney disease. J Am Soc Nephrol 2006;17:3458-3471.
Duarte C, Gomes C, Correia AJ, Salgado M. Renal amyloidosis: an uncommon complication of juvenile idiopathic arthritis. Clin Rheumatol 2006; 25:548-9.
Duarte C, Gomes C, Correia AJ, Salgado M. Renal amyloidosis: aun uncommon complication of juvenile idiopathic arthritis. Clin Rheumatology 2006;25:548-9.
Cakar N, Yalninkaya F, Ozkaya N, Tekin M, Akar N, Konak H, et al. Familial Mediterraneam fever (FMF)-associated amyloidosis in childhood. Clinical features, course and outcome. Clin Exp Rheumatolo 2001;19:S63-7.
Tank SJ, Chima RS, Shah V, Malik S, Joshi S, Mazumdar RH. Renal amyloidosis following tuberculosis.. Indian J pediatr 2000;67:679-81.
Ozen, S, Tinaztepe, K, Gucer, S, Bakkaloglu, A: Nephrotic syndrome and arthritis in a 12 year old girl. Am J Kidney Dis 2000 36: 220–224.
Xianghua Huang, Qingwen Wang, Song Jiang, Wencui Chen, Caihong Zeng and Zhihong Liu. The clinical features and outcomes of systemic AL amyloidosis: a cohort of 231 Chinese patients. Clin Kidney J 2014; 0:1-7.
Uneo T, Takeda K, Nagata M. Remission of proteinuria and preservation of renal function in patients with renl amyloidosis secondary to rheumatoid arthritis. Nephro Dial Transplant 2012;27:633-639.
Simsek B, Islek I, Simsek T, Kucukoduk S, Cengiz K, Regression of nephrotic syndrome due to amyloidosis secondary to familial Mediterranean fever following colchicine treatment. Nephrol Dial Transplt 2000;15:281-282.
Majeed HA, Ravashdeh M, El-Shanti H, Qubain H, Khuri-Bulos N, Shahin HM. Familial Mediterranean fever in children. The expanded clinical profile. QJ Med 1999;92:309-318.
Tuglular, S, Yalcinkaya, F, Paydas, S, et al: A retrospective analysis for aetiology and clinical findings of 287 secondary amyloidosis cases in Turkey. Nephrol Dial Transplant 2002 17: 2003–2005.
Min KW, Na W, jang SM, Park MH. Prognostic associations of clinical and histopathological features in renal amyloidosis. Postgrad Med J 2011;87:529-534.
- Abstract Viewed: 262 times
- PDF Downloaded: 146 times