Is Urinary Tumor Necrosis Factor Alpha a Predictor of Urological Abnormality in Children?
Journal of Pediatric Nephrology,
Vol. 2 No. 3 (2014),
19 August 2014
,
Page 119-122
https://doi.org/10.22037/jpn.v2i3.6546
Abstract
Introduction: The role of urinary Tumor Necrosis Factor Alpha (TNF-α) in the diagnosis and treatment of different disorders has been evaluated recently. This study was conducted to evaluate the correlation of urinary TNF-α with urological abnormalities in pediatric pyelonephritis.
Materials and Methods: This prospective study was conducted on children with acute pyelonephritis. Urine samples were tested for TNF-α (ELISA colorimetric, SANQUINE, USA) and creatinine in study group. Renal ultrasonography and voiding cystoureterography were performed in all patients, as well.
Results: One hundred pyelonephritic patients were enrolled in the study. Urinary TNF-α/Cr was in an abnormal range in 91.9% of the patients. This query revealed a significant correlation between urinary TNF-alpha and kidney ultrasound results (r=0.59) and grading of reflux in voiding cystoureterography (r=0.128). Furthermore, our study showed a significant difference between the level of urinary TNF-α/Cr in patients with and without abnormality on kidney ultrasonography (p value < 0.000).
Conclusions: The results of this study indicate the efficacy of urinary TNF-α in detection of inflammatory disorders such as pyelonephritis and pediatric urological abnormalities.
Keywords: Tumor Necrosis Factor-alpha; Urologic Diseases; Child.
How to Cite
References
Last-Barney K, Homon CA, Faanes RB, Merluzzi VJ: Synergistic and overlapping activities of tumor necrosis factor alpha and IL-1. Jlmmunol 1988;141:527-530.
Ewman I, Wilkinson PJ: Chemotactic activity of lymphotoxin and tumor necrosis factor a for human neutrophils. Immunol 1989;66:318-320.
Anges GE, Bombara MP, Aiyer RA, Rice GG, Palladino MA JR: Tumor necrosis factor a as a proliferative signal for an IL-2 dependent T cell line: Strict species specificity of action. J Immunol 1989;142:1203-1208.
Exley AR, Cohen J, Buurman WA, et al. Monoclonal antibody to TNF in severe septic shock. Lancet 1990;335:1275-1277.
Borm PJA, Palmen N, Engelen JJM, Buurman WA: Spontaneous and stimulated release of tumor necrosis factor a (TNF) from blood monocytes of miners with coal workers' pneumoconiosis. Am Rev Resp Dis 1988;138:1589-1594.
Von Asmuth EJU, Maessen JO, Van DER Linden CJ, Buurman WA: Tumor necrosis factor a (TNF) and interleukin 6 in a zymosan induced shock model. Scand J immunol 1990;32:313-319.
Carmen Mora MD, Juan F. Navarro MD. The role of inflammation as a pathogenic factor in the development of renal disease in diabetes. Current Diabetes Reports 2005;5(6): 399-401.
Demircan N, Safran BG, Soylu M, Ozcan MM, Sizmaz S. Determination of vitreous interleukin-1 (IL-1) and tumour necrosis factor (TNF) levels in proliferative diabetic retinopathy. Eye 2006;20:1366–1369.
Kalantarinia K, Awad AS, Siragy HM. Urinary and renal interstitial concentrations of TNF- α increase prior to the rise in albuminuria in diabetic rats. Kidney International 2003;64:1208–1213.
Jonathan Barratt, John Feehally. IgA Nephropathy. JASN 2005;16(7):2088-2097.
Van Seyfen Pa, Van Hinsbergh Vw, Van Der Velden Tj. Effects of TNFa on verocytotoxin cytotoxicity in purified human glomerular microvascular endothelial cells. Kidney International 1997;51:1245-1256.
Weisinger JR, Alonzo E, Bellorín-Font E. Possible role of cytokines on the bone mineral loss in idiopathic hypercalciuria. Kidney International 1996;49:244–250.
Gurgoze MK, Akarsu S, Yilmaz E, Godekmerdan A, Akca Z, Ciftci I. Proinflammatory cytokines and procalcitonin in children with acute pyelonephritis. Pediatr Nephrol 2005;20(10):1445-8.
Zwolińska D. Medyńska A. Szprynger K. Szczepańska M. Serum Concentration of IL-2, IL-6, TNF-Alpha and Their Soluble Receptors in Children on Maintenance Hemodialysis. Nephron 2000;86:441–446.
Mclaughlin, P. Jeremy; Aikawa, Atsushi; Davies, Helen M.; Evaluation of Sequential Plasma and Urinary Tumor Necrosis Factor Alpha Levels in Renal Allograft Recipients. Transplantation 1991;51(6).
Navarro JF, Mora C, Macía M, García J: Inflammatory parameters are independently associated with urinary albumin excretion in type 2 diabetes mellitus. Am J Kidney Dis 2003;42:53–61.
Bertini R, Delgado R, Faggioni R, Gascon MP, Ythier A, Ghezzi P. Urinary TNF-binding protein (TNF soluble receptor) protects mice against the lethal effect of TNF and endotoxic shock. European Cytokine Network 1993;4(1):39-42.
Nseyo UO, Whalen RK, Duncan MR, Berman B. Urinary cytokines following photodynamic therapy for bladder cancer a preliminary report. Urology 1990;36(2):167-171.
Mohkam M, Rafiei Tabatabaei S, Asgarian F, Armin S, Fahimzad A, Sharifian M. Urinary Tumor Necrosis Factor-Alpha a Good Indicator for Inflammatory Response in Pyelonephritis. Arch Pediatr Infect Dis.2013;1(2): 87-91.
Mohkam M, Asgarian F, Fahimzad AR, Sharifian M, Dalirani R, Abdollah Gorgi F. Diagnostic Potential of Urinary Tumor Necrosis Factor-Alpha in Children With Acute Pyelonephritis. IJKD 2009;3:89-92.
Klahr S, Morrissey J, Obstructive nephropathy and renal fibrosis. The American Journal of Physiology-Renal Physiology 2002;283(5):861–875.
Segerer S, Alpers CE. Chemokines and chemokine receptors in renal pathology. Current Opinion in Nephrology and Hypertension. 2003;12(3):243–249.
Gröne HJ, Cohen CD, Gröne E et al. Spatial and temporally restricted expression of chemokines and chemokine receptors in the developing human kidney. Journal of the American Society of Nephrology 2002;13(4):957–967.
Sheu J. N., Chen M. C, Cheng S. L, Lee IC, Chen SM, Tsay JG. Urine interleukin-1β in children with acute pyelonephritis and renal scarring. Nephrology 2007;12(5):487–493.
Sheu JN, Chen MC, Lue KH et al. Serum and urine levels of interleukin-6 and interleukin-8 in children with acute pyelonephritis. Cytokine 2006;36(5-6):276–282.
Souto MFO, Teixeira AL, Russo RC et al. Immune mediators in idiopathic nephrotic syndrome: evidence for a relation between interleukin 8 and proteinuria. Pediatric Research 2008;64(6):637–642.
Wen JG, Frøkiær J, Jørgensen TM, Djurhuus JC. Obstructive nephropathy: an update of the experimental research. Urological Research 1999;27(1):29–39.
Matsell DG, Tarantal AF. Experimental models of fetal obstructive nephropathy. Pediatric Nephrology 2002;17(7):470–476.
Klahr S. Obstructive nephropathy. Kidney International. 1998;54(1):286–300.
Misseri R, Meldrum DR, Dagher P, Hile K, Rink RC, Meldrum KK. Unilateral ureteral obstruction induces renal tubular cell production of tumor necrosis factor-α independent of inflammatory cell infiltration. Journal of Urology 2004;172(4):1595–1599.
Davidoff R, Yamaguchi R, Leach GE. Multiple urinary cytokine levels of bacterial cystitis. J Urol. 1997;157(5):1980-5.
Muller F, Dreux S, Audibert F et al. Fetal serum β2-microglobulin and cystatin C in the prediction of post-natal renal function in bilateral hypoplasia and hyperechogenic enlarged kidneys. Prenatal Diagnosis 2004;24(5):327–332.
Mesrobian H. G. O, Mitchell M. E, See W. A. Candidate urinary biomarker discovery in ureteropelvic junction obstruction: a proteomic approach. Journal of Urology 2010;184(2): 709–714.
Almodhen F, Loutochin O, Capolicchio JP, Jednak R, El-Sherbiny M. The role of bladder urine transforming growth factor-β1 concentrations in diagnosis and management of unilateral prenatal hydronephrosis. Journal of Urology 2009;182(1):292–298.
Jutley RS, Youngson GG, Eremin O, Ninan GK. Serum cytokine profile in reflux nephropathy. Pediatr Surg Int. 2000;16(1-2):64-8.
Ninan GK, Jutley RS, Eremin O. Urinary cytokines as markers of reflux nephropathy. J Urol. 1999;162(5):1739-42.
Klahr S. Obstructive nephropathy. Intern Med. 2000;39(5):355-61.
- Abstract Viewed: 290 times
- PDF Downloaded: 6984 times