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Vol. 2 No. 1 (2014)

January 2014

Is Urinary Interleukin-8 a Marker of Vesicoureteral Reflux in Children?

  • Abolhassan Seyedzadeh
  • Alireza Eskandarifar
  • Seyed Hamid Madani
  • Parisa Amoori
  • Akram Soleimani

Journal of Pediatric Nephrology, Vol. 2 No. 1 (2014), 31 January 2014 , Page 26-29
https://doi.org/10.22037/jpn.v2i1.5117 Published: 2013-12-25

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Abstract

Introduction: Developing non-invasive but accurate methods to diagnose vesicoureteral reflux (VUR) is in progress. Cytokines, such as interleukin-8 (IL-8), are important mediators in inflammatory responses and are demonstrated to change during UTI and pyelonephritis, as well. Therefore, we attempted to evaluate the differences of IL-8 in children with UTI compared to children with and without VUR to assess if it can be hypothesized to be an appropriate diagnostic marker in children with VUR.

Materials and Methods: We evaluated urine levels of IL-8 in 41 children aged 1 to 60 months who recovered from UTI for a minimum duration of 2-3 weeks. They were divided into 2groups: A and B (with and without VUR, respectively). Additionally, a group of normal children was considered as the control group (group C). Urine IL-8 levels were measured for the three groups and corrected for urine creatinine (Cr) (IL-8/Cr). Afterwards, they were compared using One-Way ANOVA test.

Results: The mean IL-8/Cr level was 81.7 ± 90.1 in group A, 289.8±640.2 in group B, and 9.6 ± 12.2 in group C with no significant difference (p=0.056).

Conclusions: Our finding suggests there is no significant difference in urine IL-8/Cr levels between patients with and without VUR and therefore, we cannot propose IL-8 as a diagnostic marker for VUR. 

Keywords: Interleukin-8; Pediatrics; Pyelonephritis; Urinary Tract Infections; Vesico-Ureteral Reflux.

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How to Cite

1.
Seyedzadeh A, Eskandarifar A, Madani SH, Amoori P, Soleimani A. Is Urinary Interleukin-8 a Marker of Vesicoureteral Reflux in Children?. J Ped Nephrol [Internet]. 2013 Dec. 25 [cited 2023 Nov. 30];2(1):26-9. Available from: https://journals.sbmu.ac.ir/jpn/article/view/5117
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