The Evaluation of Serum Vitamin D Levels in Pediatric Patients With Vesicoureteral Reflux
Journal of Pediatric Nephrology,
Vol. 10 No. 2 (2022),
1 October 2022
,
Page 91-95
https://doi.org/10.22037/jpn.v10i2.38193
Abstract
Background and Aim: Vesicoureteral Reflux (VUR) refers to the pathological return
of urine from the bladder to the ureter and then to the kidney in some patients. Vitamin D
deficiency is associated with some renal diseases. This study examines the relationship
between vitamin D deficiency and urinary reflux.
Methods: In this cross-sectional study, 200 children referred to Amir Kabir Hospital
in Arak, Iran, were divided into 2 groups of patients with VUR (n=100) and another
group of pediatric participants considered healthy and had no findings of VUR (n=100).
Confirmation of diagnosis was performed via voiding cystourethrogram. Serum vitamin
D levels were evaluated by the Enzyme-Linked Immunosorbent Assay (ELISA) method
in all participants.
Results: The results showed that the rate of vitamin D deficiency was 38% and 42%
in the case and control groups, respectively. Therefore, no significant correlation was
observed between the two study groups in terms of vitamin D deficiency. This finding
was regardless of VUR complications affecting vitamin D metabolism.
Conclusion: We assume that VUR is a complicated condition with several
complications, and the relationship of each complication with vitamin D deficiency has
been determined to some extent in previous studies; however, this condition cannot be
considered an independent factor leading to vitamin D deficiency.
- Vitamin D Deficiency
- Vesicoureteral Reflux
- Complications
- Pediatrics
How to Cite
References
2. Skoog SJ, Peters CA, Arant BS, Copp HL, Elder JS, Hudson RG, et al. Pediatric vesicoureteral reflux guidelines panel summary report: clinical practice guidelines for screening siblings of children with vesicoureteral reflux and neonates/infants with prenatal hydronephrosis. The Journal of urology. 2010;184(3):1145-51.
3. Bocquet N, Alaoui AS, Jais J-P, Gajdos V, Guigonis V, Lacour B, et al. Randomized trial of oral versus sequential IV/oral antibiotic for acute pyelonephritis in children. Pediatrics. 2012;129(2):e269-e75.
4. Fulgoni III VL, Keast DR, Bailey RL, Dwyer J. Foods, fortificants, and supplements: where do Americans get their nutrients? The Journal of nutrition. 2011;141(10):1847-54.
5. Levey AS, De Jong PE, Coresh J, Nahas ME, Astor BC, Matsushita K, et al. The definition, classification, and prognosis of chronic kidney disease: a KDIGO Controversies Conference report. Kidney international. 2011;80(1):17-28.
6. Lips P. Vitamin D physiology. Progress in biophysics and molecular biology. 2006;92(1):4-8.
7. Robert M. Kliegman BS JSG, Nina Felice Schor, Richard E. Behrman. Nelson Textbook of Pediatrics2011.
8. Souberbielle J-C, Body J-J, Lappe JM, Plebani M, Shoenfeld Y, Wang TJ, et al. Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice. Autoimmunity reviews. 2010;9(11):709-15.
9. Malabanan A, Veronikis I. Redefining vitamin D insufficiency. The Lancet. 1998;351(9105):805-6.
10. Bosworth C, de Boer IH, editors. Impaired vitamin D metabolism in CKD. Seminars in nephrology; 2013: Elsevier.
11. Dragonas P, Kaste LM, Nunn M, Gajendrareddy PK, Weber KM, Cohen M, et al. Vitamin D deficiency and periodontal clinical attachment loss in HIV-seropositive women: A secondary analysis conducted in the Women's Interagency HIV Study (WIHS). Oral surgery, oral medicine, oral pathology and oral radiology. 2018;125(6):567-73.
12. Muntean C, Săsăran M. Vitamin D Status and Its Role in First-Time and Recurrent Urinary Tract Infections in Children: A Case-Control Study. Children. 2021;8(5):419.
13. Yates NJ, Tesic D, Feindel KW, Smith JT, Clarke MW, Wale C, et al. Vitamin D is crucial for maternal care and offspring social behaviour in rats. Journal of Endocrinology. 2018;237(2):73-85.
14. Aslan S, Akil I, Aslan G, Onay H, Ozyurt BC, Ozkinay F. Vitamin D receptor gene polymorphism in children with urinary tract infection. Pediatric Nephrology. 2012;27(3):417-21.
15. Deng Q-F, Chu H, Wen Z, Cao Y-S. Vitamin D and urinary tract infection: a systematic review and meta-analysis. Annals of Clinical & Laboratory Science. 2019;49(1):134-42.
16. Katikaneni R, Ponnapakkam T, Ponnapakkam A, Gensure R. Breastfeeding does not protect against urinary tract infection in the first 3 months of life, but vitamin D supplementation increases the risk by 76%. Clinical pediatrics. 2009;48(7):750-5.
17. Tekin M, Konca C, Celik V, Almis H, Kahramaner Z, Erdemir A, et al. The association between vitamin D levels and urinary tract infection in children. Hormone research in paediatrics. 2015;83(3):198-203.
18. Yang J, Chen G, Wang D, Chen M, Xing C, Wang B. Low serum 25-hydroxyvitamin D level and risk of urinary tract infection in infants. Medicine. 2016;95(27).
19. Garcia-Roig ML, Kirsch AJ. Urinary tract infection in the setting of vesicoureteral reflux. F1000Research. 2016;5.
20. Mattoo TK. Vesicoureteral reflux and reflux nephropathy. Advances in chronic kidney disease. 2011;18(5):348-54.
21. Silva JMP, Diniz JSS, Silva ACS, Azevedo MV, Pimenta MR, Oliveira EA. Predictive factors of chronic kidney disease in severe vesicoureteral reflux. Pediatric Nephrology. 2006;21(9):1285-92.
22. Brodersen LA, Nielsen PR, Thiesson HC, Marckmann P. Vitamin D status in children and adolescents with kidney transplants. Pediatric transplantation. 2011;15(4):384-9.
23. Kalkwarf HJ, Denburg MR, Strife CF, Zemel BS, Foerster DL, Wetzsteon RJ, et al. Vitamin D deficiency is common in children and adolescents with chronic kidney disease. Kidney international. 2012;81(7):690-7.
24. Kumar J, McDermott K, Abraham AG, Friedman LA, Johnson VL, Kaskel FJ, et al. Prevalence and correlates of 25-hydroxyvitamin D deficiency in the Chronic Kidney Disease in Children (CKiD) cohort. Pediatric nephrology. 2016;31(1):121-9.
25. Shroff R, Knott C, Gullett A, Wells D, Marks SD, Rees L. Vitamin D deficiency is associated with short stature and may influence blood pressure control in paediatric renal transplant recipients. Pediatric nephrology. 2011;26(12):2227-33.
26. Tuchman S, Kalkwarf HJ, Zemel BS, Shults J, Wetzsteon RJ, Foerster D, et al. Vitamin D deficiency and parathyroid hormone levels following renal transplantation in children. Pediatric Nephrology. 2010;25(12):2509-16.
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