Prevalence of Microalbuminuria in Children with Asymptomatic Microscopic Hematuria
Journal of Pediatric Nephrology,
Vol. 5 No. 1 (2017),
6 June 2017
,
Page 1-4
https://doi.org/10.22037/jpn.v5i1.16659
Abstract
Introduction: A wide range of chronic and acute diseases begin with asymptomatic microscopic hematuria. Simultaneous presence of microalbuminuria and microscopic hematuria is suggestive of an important kidney disease. The purpose of this study was to determine the prevalence of microalbuminuria in children with asymptomatic microscopic hematuria.
Materials and Methods: This cross-sectional study was done on 150 children aged 2-14 years with asymptomatic microscopic hematuria at Nephrology Clinic of Children’s Hospital Medical Center in 2013-2015. All patients had clinical and laboratory tests such as BUN, creatinine, electrolytes, urine albumin/ creatinine ratio, blood pressure, etc. The obtained data were recorded and analyzed with SPSS (ver. 18). All children with anatomical anomalies, hypertension, previous urinary tract surgery, or nephrolithiasis were excluded from the study.
Results: The overall prevalence of microalbuminuria was 14.5 % and there was a significant relationship between microalbuminuria and the presence of dysmorphic red blood cells on urine analysis (p-value<0.05). The incidence of RBC cast was 54% (82 patients). Two children had upper-normal levels of blood pressure for age and sex that were followed closely and received special diets and medications. Twenty-nine patients (18.6%) had a positive family history of asymptomatic microscopic hematuria and the father of one of them had IgA nephropathy with ESRD. In children with microalbuminuria that received drugs for 3-28 months (mean, 6.3 months), microalbuminuria decreased significantly.
Conclusions: Isolated asymptomatic microscopic hematuria is a benign disease but its association with proteinuria may indicate a serious problem with the risk of progressive renal disease. It is recommended to determine the microalbumin/creatinine ratio in cases with asymptomatic microscopic hematuria.
Keywords: Asymptomatic Microscopic Hematuria; Microalbuminuria; Prevalence; Child.
- asymptomatic microscopic hematuria
- microalbuminuria
- prevalence
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References
Cho BS, Kim SD. School urinalysis screening in Korea. Nephrology. 2007; 12: S3–7.
Edwards TJ, Andrew J, Gosling J, Mcgrath JS. A prospective analysis of the diagnostic yield resulting from the attendance of 4020 patients at a protocol-driven haematuria clinic. BJU Int 2006; 97: 301-5.
Kincaid-Smith P, Fairley K. The investigation of hematuria. Semin Nephrol. 2005;25(3):127-135.
Yap HK, Yew-Weng LP. Hematuria and proteinuria. In: Geary DF, Schaefer F, editors. Comprehensive Pediatric Nephrology. Mosby Elsevier; 2008. pp. 179-193.
Fogazzi GB, Edefonti A, Garigali G, et al. Urine erythrocyte morphology in patients with microscopic haematuria caused by a glomerulopathy. Pediatr Nephrol 2008; 23:1093.
Yates DR, Catto JF. Investigation of haematuria. The Foundation Years. 2006; 22: 80-2.
Hui-Ming Chung ,Yung-Ming Liao , Yung-Chen Tsai , Ming-Chen Liu, Microscopic hematuria in children, Urological Science, journal homepage: www.urol-sci.com
Meyers KE. Evaluation of hematuria in children. Urol Clin North Am. 2004;31(3):559-573.
Macanovic M, Mathieson P. Primary glomerular disease. Medicine. 2007; 35: 490-6.
Walbaum D, Kluth D. Clinical assessment of renal disease. Medicine 2007; 35(7): 353-8.
Mohd Ashraf, Nazir Ahmed Parray , Reyaz A Malla, Shafaqat Rasool, Kaisar Ahmed, Hematuria in Children, Int J Clin Pediatr. 2013;2(2):51-60.
Farahnak K. Assadi, Value of urinary excretion of microalbumin in predicting glomerular lesions in children with isolated microscopic hematuria, Pediatr Nephrol 2005;20:1131–1135, DOI 10.1007/s00467-005-1928-3.
Eardley KS, Ferreira MAS, Howie AJ, Gosling P, Lipkin GW, Urinary albumin excretion: a predictor of glomerular findings in adults with microscopic hematuria. QJ Med 2004;97:297– 301.
Endo M, Ohi H, Satomura A Regulation of in situ complement activation via the lectin pathway in patients with IgA nephropathy. Clin Nephrol 2001;55:185–191.
D- Amico G. Natural history of idiopathic IgA nephropathy role of clinical and histological prognostic factors, Am J Kidney Dis,2000; 36:277-37.
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