The Mean Platelet Volume in children with Pyelonephritis
Journal of Pediatric Nephrology,
Vol. 4 No. 2 (2016),
4 July 2016
Introduction: The mean platelet volume (MPV) is a determinant of inflammation. The aim of the present study was to investigate the MPV levels in children with pyelonephritis and to evaluate the possible relationship between MPV and febrile UTI.
Materials and Methods: In this prospective observational study, 82 patients with Pyelonephritis (group A) and 82 patients with viral gastroenteritis (group B) were enrolled from 20 Jun 2013 through 15 Jan 2014. The patients were divided into two groups according to the presence of pyelonephritis and viral gastroenteritis. The pyelonephritis group (A) included 82 patients and the acute gastroenteritis group (B) included 82 patients. Complete blood count (CBC) parameters were measured at admission. Routine biochemical tests were performed. Groups were compared according to different parameters.
Results: A total of 164 patients were included from inpatients of Amir-Kabir Hospital. The mean platelet volume was lower in group (A) and it was associated with acute pyelonephritis (P =0 .003). The MPV (6.03 ± 0.26 fl vs. 9.06 ± 0.73 fl) was significantly lower in group (A), the platelet count (219.88-± 52.31vs. 184.09 ± 52.21) was significantly higher in group (A), and the WBC count (13.01± 3.43 vs. 8.30 ± 1.13) was significantly higher in group (A).
Conclusions: MPV levels were significantly lower in children with pyelonephritis compared with controls. MPV can be used as a negative acute phase reactant in children with febrile UTI.Keywords: Child; Pyelonephritis; Mean Platelet Volume; Urinary tract infection.
How to Cite
Yousefichaijan P, Rafiei M, Eghbali A. et al. Mean Platelet Volume: A useful marker ln reflux nephropathy. J Ped. Nephrology 2014;2(4):137-139.
Yousefichaijan P, Cyrus A, Dorreh F, et al. Correlation of sacral ratio and reflux – related renal injury in children with and without nephropathy. J Ped. Nephrology 2014;2(3): 116-118.
Jack S.Elder, Kliegman, Stanton, St.Geme, Schor, Behrman. Nelson Textbook of Pediatric 19th edition, Elsevier Saunders,2011 chapter 533,P 1834-46.
Yousefichaijan P, Cyrus A, Dorreh F, Ahmadi Mohtasham M. Comparing the sacral ratio in children with various degree of Vesicoureteral reflux with children without reflux. AMUJ 2005;10( 3):94-99.
Parsa Yousefi, Ali Siroos, Fatemeh Darreh, et al. Sacrum index in children suffering from different grades of VUR. Pakistan journal of biological sciences 2013;16 (11):545-547.
Shaikh N, Ewing AL, Bhatnagar S, Hoberman A. Risk of renal scarring in children with a first urinary tract infection: a systematic review. Pediatrics. 2010;126:1084–91.
Edefonti A, Tel F, Testa S, De Palma D. Febrile urinary tract infections: clinical and laboratory diagnosis, imaging, and prognosis. SeminNucl Med. 2014;44:123–8.
Yousefichaijan P, Dorreh Fatemeh. Urinary tract infection due to salmonella in an otherwise healthy child. Iranian journal of kidney diseases 2014;8(2):155-7.
Elder JS. Urinary tract infection. In: Kliegman RM, Stanton BF, St. Geme JW, Schor NF, Behrman RE, editors. Nelson textbook of pediatrics. 19th ed. Philadelphia: Saunders; 2011. pp. 1829–38.
Yousefichaijan P, Ali Cyrus, Fatemeh Dorreh. Evaluation of Additional fluid (1.5 times the maintenance) on the Urinary Tract Infections Therapy in Children. Journal of Ardabil University of Medical Sciences 2008;8(3):321-325.
Tekin M, Konca C, Gulyuz A, Uckardes F, Turgut M. Is the mean platelet volume a predictive marker for the diagnosis of acute pyelonephritis in children? ClinExpNephrol. 2014 ;4.
Catal F, Bavbek N, Bayrak O, et al. Platelet parameters in children with upper urinary tract infection: is there a specific response? Ren Fail. 2008;30(4):377-81.
Han JS, Park KS, Lee MJ, et al., Mean platelet volume is a prognostic factor in patients with acute kidney injury requiring continuous renal replacement therapy, J Crit Care 2014;29(6):1016-21.
Mete E, Akelma AZ, Cizmeci MN, Bozkaya D, Kanburoglu MK. Decreased mean platelet volume in children with acute rotavirus gastroenteritis. Platelets 2014;25(1):51-4.
Tanju C, Ekrem G, BerksoyEmel A, Nur A. Mean platelet volume as a negative marker of inflammation in children with rotavirus gastroenteritis. Iran J Pediatric. 2014 Oct; 24(5):617-22.
Zareifar S, Farahmand Far MR, Golfeshan F, Cohan N. Changes in platelet count and mean platelet volume during infectious and inflammatory disease and their correlation with ESR and CRP. J Clin Lab Anal 2014 May; ]28(3):245-8.
Kapsoritakis AN, Koukourakis MI, Sfiridaki A, et al. Mean platelet volume: a useful marker of inflammatory bowel disease activity. Am J Gastroenterology 2001;96:776–781.
Song Liu, Jiana Ren, Gang Han, Gefei Wang. MPV: controversial marker of disease activity in Crohn’s disease. Euro J Med Res 2012;17(1):27.
GulsahGunluoglu,EsraErtanYazar,NurdanSimsekVeske, EkremCengizSeyhan, SedatAltin. MPV as an inflammation marker in active pulmonary tuberculosis. Multidiscipline Respir Med 2014; 9(1):11.
Akelma AZ, Mete E, Cizmeci MN, Kanburoglu MK, Malli DD, Bozkaya D. The role of MPV as an inflammatory marker in children. Allergol Immunopathology (Madr) 2013 Aug 19.
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