Assessment of the Systemic Inflammatory Indices in Patients with Endometriosis with Long COVID Inflammatory Indices in Endometriosis with Long COVID
Student Research in Translational Medicine,
Vol. 7 (2025),
1 Esfand 2025
,
Page 1-8
https://doi.org/10.22037/srtm.v7.50048
Abstract
Background and Aim: Endometriosis is a chronic inflammatory disease, and Long COVID is a syndrome of persistent symptoms following SARS-CoV-2 infection. These two conditions may share common inflammatory pathways. This study aimed to compare systemic inflammatory indices between patients with endometriosis with long COVID and healthy individuals.
Methods: A cross- sectional study involving 40 participants, including 20 patients with laparoscopically confirmed endometriosis and 20 healthy individuals as a control group, was conducted. Each group was further divided into subgroups based on Long COVID, confirmed through RT-PCR and a questionnaire, resulting in four groups: a healthy control group without Long COVID (n = 10), a healthy control group with Long COVID (n = 10), an endometriosis group without Long COVID (n = 10), and an endometriosis group with Long COVID (n = 10). The immune system inflammation index (SII), neutrophil- to- lymphocyte ratio (NLR), platelet- to- lymphocyte ratio (PLR), immune system inflammation amount (PIV), and systemic inflammatory response index (SIRI) were calculated from blood samples. Non- parametric tests were used for the statistical analysis.
Results: The immune system inflammation index (SII) was significantly higher in patients with endometriosis and Long COVID than in patients without Long COVID (995.25 vs. 612.48; p = 0.0193). Similarly, the platelet-to-lymphocyte ratio (PLR) was significantly higher in the Long COVID endometriosis group than in the endometriosis- only group (168.65 vs. 99.24; p = 0.0471). Although not statistically significant, a consistent upward trend was observed in the NLR, PIV, and SIRI levels in the Long COVID endometriosis group. No significant increases in these indices were observed in healthy individuals with Long COVID.
Conclusion: Long COVID is significantly associated with increased SII and PLR in patients with endometriosis, highlighting the unique vulnerability of patients with endometriosis to pre- inflammatory complications of SARS-CoV-2 infection. Readily available inflammatory indices, such as the SII, can serve as useful biomarkers for monitoring the inflammatory burden in this patient population.
- Post-Acute COVID-19 Syndrome
- Endometriosis
- Neutrophils
- Lymphocyte Count
- Platelet Count
How to Cite
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