Unsuccessful Infertility Treatment and Psychological Outcomes: A Prospective Cohort Study
Student Research in Translational Medicine,
Vol. 7 (2025),
1 March 2025
,
Page 1-9
Abstract
Background and Aim: To quantitatively examine the association between the negative outcome of infertility treatment and psychological disorders in infertile women and to determine any difference in their post- treatment mental health compared to those who had a successful cycle.
Methods: This study included sixty- one infertile women who underwent infertility treatment between December 2022 and July 2023. Their mental health status was assessed with three self- reported measurement tools before the treatment and again after identifying the pregnancy test result.
Results: Women who had a positive test result were recruited into the successful group
(n= 13), and those with a negative test were included in the unsuccessful group (n= 48). Women who had an unsuccessful treatment showed a significant increase in their levels of depression, anxiety, stress, hopelessness, and grief (P-value < 0.001). In comparison between women with successful and unsuccessful treatment, infertile women in the unsuccessful group showed higher levels of depression, anxiety, stress, hopelessness, and grief after the treatment (P-value < 0.001).
Conclusion: An unsuccessful treatment may potentially increase infertile women's psychological disorders. This suggests that addressing the psychological aspect alongside infertility treatments for infertile women may help achieve a comprehensive treatment approach.
- Mental health
- Infertility
- Psychological disorders
- IVF/ICSI

How to Cite
References
Kaur A. Role of Ayurvedic herbs for healthy pregnancy. International Journal of Research in Engineering, Science and Management. 2022;5(12):16-7.
Kawamura K, Sato Y. Effectiveness of supplement ingredients on infertility treatment in advanced aged women. Journal of Obstetrics and Gynaecology Research. 2023.
Naeem A, Khan MZ, Khan A, Abbas SH, Khan S. Amniotic stem cells as a source of regenerative medicine to treat female infertility. Human Cell. 2023;36(1):15-25.
Peng M, Zhang J, Zeng T, Hu X, Min Z. Stress, anxiety, and depression in infertile couples are not associated with a first IVF or ICSI treatment outcome. BMC Pregnancy and Childbirth. 2021;21(1):1-8.
Lynch CD, Sundaram R, Maisog JM, Sweeney AM, Buck Louis GM. Preconception stress increases the risk of infertility: results from a couple-based prospective cohort study—the LIFE study. Human Reproduction. 2014;29(5):1067-75.
Sominsky L, Sobinoff AP, Jobling MS, Pye V, McLaughlin EA, Hodgson DM. Linking stress and infertility: a novel role for ghrelin. Endocrine Reviews. 2017;38(5):432-67.
Smeenk JM, Verhaak CM, Vingerhoets AJ, Sweep CG, Merkus JM, Willemsen SJ, et al. The effect of anxiety and depression on the outcome of in-vitro fertilization. Human Reproduction. 2001;16(7):1420-3.
Klonoff-Cohen H, Chu E, Natarajan L, Sieber W. A prospective study of stress among women undergoing in vitro fertilization or gamete intrafallopian transfer. Fertility and Sterility. 2001;76(4):675-87.
Zagami SE, Latifnejad Roudsari R, Janghorban R, Mousavi Bazaz SM, Amirian M, Allan HT. A qualitative study of the experiences of Iranian infertile couples after unsuccessful assisted reproductive technologies. International Journal of Women's Health and Reproduction Sciences. 2019;7(3):331-8.
Pasch LA, Gregorich SE, Katz PK, Millstein SG, Nachtigall RD, Bleil ME, et al. Psychological distress and in vitro fertilization outcome. Fertility and Sterility. 2012;98(2):459-64.
Cheung CS, Chan CH, Ng EH. A prospective observational study on the stress levels at the time of embryo transfer and pregnancy testing following in vitro fertilisation treatment: a comparison between women with different treatment outcomes. BJOG: An International Journal of Obstetrics & Gynaecology. 2019;126(2):271-9.
Verhaak CM, Smeenk JM, Evers AW, Kremer JA, Kraaimaat FW, Braat DD. Long-term psychological adjustment to IVF/ICSI treatment in women. Human Reproduction. 2007;22(1):305-8.
Verhaak CM, Smeenk JM, van Minnen A, Kremer JA, Kraaimaat FW. Stress and marital satisfaction among women before and after their first cycle of in vitro fertilization and intracytoplasmic sperm injection. Fertility and Sterility. 2001;76(3):525-31.
Palmer EJ, Connelly R. Depression, hopelessness and suicide ideation among vulnerable prisoners. Criminal Behaviour and Mental Health. 2005;15(3):164-70.
Bener A, Alsulaiman R, Doodson L, El Ayoubi HR. Depression, hopelessness and social support among breast cancer patients: in highly endogamous population. Asian Pacific Journal of Cancer Prevention. 2017;18(7):1889.
Shahini N, Ebrahimzadeh A, Shahini N. Grief experience after deaths: Comparison of COVID-19 and non-COVID-19 causes. Journal of Patient Experience. 2022;9:23743735221089697.
Moradinazar M, Najafi F, Jalilian F, Pasdar Y, Hamzeh B, Shakiba E, et al. Epidemiological status of depressive disorders in the Middle East and North Africa from 1990 to 2019. Health Promotion Perspectives. 2022;12(3):301.
Vikström J, Josefsson A, Bladh M, Sydsjö G. Mental health in women 20–23 years after IVF treatment: a Swedish cross-sectional study. BMJ Open. 2015;5(10):e009426.
Aimagambetova G, Terzic S, Laganà AS, Bapayeva G, Ukybassova T, Aldiyarova A, et al. The effect of psychological distress on IVF outcomes: Reality or speculations? PLoS One. 2020;15(12):e0242024.
Ebbesen SM, Zachariae R, Mehlsen MY, Thomsen D, Højgaard A, Ottosen L, et al. Stressful life events are associated with poor in-vitro fertilization (IVF) outcome: a prospective study. Human Reproduction. 2009;24(9):2173-82.
Thiering P, Beaurepaire J, Jones M, Saunders D, Tennant C. Mood state as a predictor of treatment outcome after in vitro fertilization/embryo transfer technology (IVF/ET). Journal of Psychosomatic Research. 1993;37(5):481-91.
Szkodziak F, Krzyżanowski J, Szkodziak P. Psychological aspects of infertility: A systematic review. Journal of International Medical Research. 2020;48(6):0300060520932403.
Horwath E, Johnson J, Klerman GL, Weissman MM. What are the public health implications of subclinical depressive symptoms? Psychiatric Quarterly. 1994;65:323-37.
Verhaak CM, Smeenk JM, Evers AW, Kremer JA, Kraaimaat FW, Braat DD. A longitudinal, prospective study on emotional adjustment before, during, and after consecutive fertility treatment cycles. Human Reproduction. 2005;20(8):2253-60.
Volgsten H, Skoog Svanberg A, Ekselius L, Lundkvist O, Sundström Poromaa I. Risk factors for psychiatric disorders in infertile women and men undergoing in vitro fertilization treatment. Fertility and Sterility. 2010;93(4):1088-96.
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