Photobiomodulation in Cancer Therapy
Student Research in Translational Medicine,
Vol. 7 (2025),
1 Esfand 2025
,
Page 1-6
https://doi.org/10.22037/srtm.v7.46940
Abstract
Background and Aim: Photobiomodulation (PBM), also known as low-level light therapy (LLLT), is a new adjuvant therapy in oncology that holds promise for improving treatment outcomes by reducing side effects related to conventional therapies like chemotherapy, radiotherapy, and immunotherapy. PBM uses selected wavelengths of light to modulate the biological processes, which induce therapeutic effects by interacting with mechanisms such as cytochrome c oxidase, increased adenosine triphosphate (ATP) production, control of reactive oxygen species (ROS), modulation of gene expression, and anti- inflammatory responses. The current review aims to discuss the applications, benefits, challenges, and future directions of PBM in oncology.
Methods and Materials: A wide literature review was carried out in order to assess the clinical and experimental data for PBM applications in oncology. In particular, this paper will aim to understanding the mechanism, the safety concern, and its potentiality as a personalized therapeutic approach. Variability in the responses obtained in different patients due to
non- standardization of the parameters of PBM treatment, like wavelength, dosage, and treatment time, is analyzed.
Results: PBM has shown significant promise in the promotion of tissue repair and reduction of inflammation, thus being effective in the management of complications such as mucositis, dermatitis, and neuropathy. However, concerns about potential tumor stimulation effects under certain conditions raise a call for caution in its application. Variability in patient and
tumor- specific responses remains a critical barrier to standardization and broader adoption.
Conclusion: PBM could revolutionize cancer care by acting complementary to the standard treatments, improving therapeutic outcomes, and enhancing quality of life. Further research will be required to optimize protocols, address safety concerns, and establish PBM as a personalized and standard component of oncology treatment plans.
- Photobiomodulation (PBM)
- Low-level laser therapy (LLLT)
- Immunotherapy
- Biological processes
- Cancer
How to Cite
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