Preparation and Evaluation of Polymeric Nanofibers Containing Griseofulvin –Microemulsion by Electrospinning Process Polymeric Nanofibers Loaded with Microemulsion: Preparation and Evaluation
Iranian Journal of Pharmaceutical Sciences,
卷 19 编号 4 (2023),
24 اردیبهشت 2024
,
第 339-349 页
https://doi.org/10.22037/ijps.v19i4.43816
摘要
In this study, the purpose of preparing CS/PVA nanofibers loaded GRF microemulsion is to increase the solubility of Low soluble drug griseofulvin by using microemulsion nanocarrier, and nanofiber was used as a technique for a new product. This drug is one of the antifungal drugs, and its uses are for skin diseases. Therefore, a topical route can be a good option. Chitosan /polyvinyl alcohol (CS/PVA) nanofiber containing griseofulvin (GRF) loaded microemulsion was obtained. The microemulsion comprised oleic acid and Transcutol P as the oil phase, Span20 and Labrasol as the surfactant, and Plurol oleique as the cosurfactant. Formulations were prepared with a ME(GRF): polymer ratio (30: 70) and (40: 60) and a polymeric solution containing chitosan (2%) and polyvinyl alcohol (10%) at two weight ratio (20: 80) and (10: 90), respectively. The physicochemical characteristics of the GRF-CS/PVA nanofibers were evaluated. The differential scanning calorimetry (DSC) study showed the amorphous state of the GRF-loaded microemulsions and PVA polymer embedded into the nanofibers. The entrapment efficiency percentage of GRF in the mats was approximately 66.67% - 88.89%. Drug release behavior showed controlled and slow release of drugs that are affected by the type of microemulsion formulation and the ratio of polymers used in nanofibers.
- Grisofulvin
- Microemulsion
- Electrospinning
- Biodegradable polymers
- Nanofiber
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参考
Oxford AE, Raistrick H, Simonart P. Studies in the biochemistry of micro-organisms: griseofulvin, C17H17O6Cl, a metabolic product of Penicillium griseo-fulvum Dierckx. Biochemical Journal.(1939)33(2):240.
Kassem MA, Esmat S, Bendas ER, El‐Komy MH. Efficacy of topical griseofulvin in treatment of tinea corporis. Mycoses.(2006)49(3):232-5.
Millikan LE. Current concepts in systemic and topical therapy for superficial mycoses. Clinics in dermatology.(2010)28(2):212-6.
Rudy S, editor Superficial fungal infections in children and adolescents. Nurse practitioner forum; 1999.
Hentzschel C, Alnaief M, Smirnova I, Sakmann A, Leopold C. Enhancement of griseofulvin release from liquisolid compacts. European Journal of Pharmaceutics and Biopharmaceutics.(2012)80(1):130-5.
Y, Metsugi Y, Ogawara K-i, Higaki K, Kimura T. Evaluation of in vivo dissolution behavior and GI transit of griseofulvin, a BCS class II drug. International journal of pharmaceutics.(2008)352(1-2):36-43.
Chattopadhyay P, Gupta RB. Production of griseofulvin nanoparticles using supercritical CO2 antisolvent with enhanced mass transfer. International journal of pharmaceutics.(2001)228(1-2):19-31.
Aggarwal N, Goindi S, Khurana R. Formulation, characterization and evaluation of an optimized microemulsion formulation of griseofulvin for topical application. Colloids and Surfaces B: Biointerfaces.(2013)105:158-66.
Kreilgaard M. Influence of microemulsions on cutaneous drug delivery. Advanced drug delivery reviews.(2002)54:S77-S98.
Radomska-Soukharev A, Wojciechowska J. Microemulsions as potential ocular drug delivery systems: phase diagrams and physical properties depending on ingredients. Acta Pol Pharm.(2005)62(6):465-71.
Trotta M, Gallarate M, Carlotti ME, Morel S. Preparation of griseofulvin nanoparticles from water-dilutable microemulsions. International journal of pharmaceutics.(2003)254(2):235-42.
Moghimipour E, Salimi A, Karami M, Isazadeh S. Preparation and characterization of dexamethasone microemulsion based on pseudoternary phase diagram. Jundishapur journal of natural pharmaceutical products.(2013)8(3):105.
Salimi A, Moghimipour E, Tavakolbekhoda N. Transdermal delivery of celecoxib through rat skin from various microemulsions. skin.(2013)8:9.
Reneker D, Yarin A, Zussman E, Xu H. Electrospinning of nanofibers from polymer solutions and melts. Advances in applied mechanics.(2007)41:43-346.
Wu H, Zhang R, Sun Y, Lin D, Sun Z, Pan W, et al. Biomimetic nanofiber patterns with controlled wettability. Soft matter.(2008)4(12):2429-33.
Baker SC, Atkin N, Gunning PA, Granville N, Wilson K, Wilson D, et al. Characterisation of electrospun polystyrene scaffolds for three-dimensional in vitro biological studies. Biomaterials.(2006)27(16):3136-46.
Maretschek S, Greiner A, Kissel T. Electrospun biodegradable nanofiber nonwovens for controlled release of proteins. Journal of Controlled Release.(2008)127(2):180-7.
Ra EJ, An KH, Kim KK, Jeong SY, Lee YH. Anisotropic electrical conductivity of MWCNT/PAN nanofiber paper. Chemical Physics Letters.(2005)413(1-3):188-93.
Chang C-C, Huang C-M, Chang Y-H, Kuo C. Enhancement of light scattering and photoluminescence in electrospun polymer nanofibers. Optics Express.(2010)18(102):A174-A84.
Cuenot S, Demoustier-Champagne S, Nysten B. Elastic modulus of polypyrrole nanotubes. Physical Review Letters.(2000)85(8):1690.
Arinstein A, Burman M, Gendelman O, Zussman E. Effect of supramolecular structure on polymer nanofibre elasticity. Nature nanotechnology.(2007)2(1):59-62.
Arinstein A, Zussman E. Electrospun polymer nanofibers: mechanical and thermodynamic perspectives. Journal of Polymer Science Part B: Polymer Physics.(2011)49(10):691-707.
Agarwal S, Greiner A, Wendorff JH. Functional materials by electrospinning of polymers. Progress in Polymer Science.(2013)38(6):963-91.
Sanders EH, Kloefkorn R, Bowlin GL, Simpson DG, Wnek GE. Two-phase electrospinning from a single electrified jet: microencapsulation of aqueous reservoirs in poly (ethylene-co-vinyl acetate) fibers. Macromolecules.(2003)36(11):3803-5.
Xu X, Yang L, Xu X, Wang X, Chen X, Liang Q, et al. Ultrafine medicated fibers electrospun from W/O emulsions. Journal of Controlled Release.(2005)108(1):33-42.
Han J, Chen T-X, Branford-White CJ, Zhu L-M. Electrospun shikonin-loaded PCL/PTMC composite fiber mats with potential biomedical applications. International journal of pharmaceutics.(2009)382(1-2):215-21.
Sy JC, Klemm AS, Shastri VP. Emulsion as a means of controlling electrospinning of polymers. Advanced Materials.(2009)21(18):1814-9.
Liao Y, Zhang L, Gao Y, Zhu Z-T, Fong H. Preparation, characterization, and encapsulation/release studies of a composite nanofiber mat electrospun from an emulsion containing poly (lactic-co-glycolic acid). Polymer.(2008)49(24):5294-9.
Shao C, Kim H-Y, Gong J, Ding B, Lee D-R, Park S-J. Fiber mats of poly (vinyl alcohol)/silica composite via electrospinning. Materials Letters.(2003)57(9-10):1579-84.
Yao L, Haas TW, Guiseppi-Elie A, Bowlin GL, Simpson DG, Wnek GE. Electrospinning and stabilization of fully hydrolyzed poly (vinyl alcohol) fibers. Chemistry of Materials.(2003)15(9):1860-4.
Koski A, Yim K, Shivkumar S. Effect of molecular weight on fibrous PVA produced by electrospinning. Materials Letters.(2004)58(3-4):493-7.
Yan E, Cao M, Wang Y, Hao X, Pei S, Gao J, et al. Gold nanorods contained polyvinyl alcohol/chitosan nanofiber matrix for cell imaging and drug delivery. Materials Science and Engineering: C.(2016)58:1090-7.
Yang JM, Yang JH, Tsou SC, Ding CH, Hsu CC, Yang KC, et al. Cell proliferation on PVA/sodium alginate and PVA/poly (γ-glutamic acid) electrospun fiber. Materials Science and Engineering: C.(2016)66:170-7.
Lee YJ, Shin DS, Kwon OW, Park WH, Choi HG, Lee YR, et al. Preparation of atactic poly (vinyl alcohol)/sodium alginate blend nanowebs by electrospinning. Journal of applied polymer science.(2007)106(2):1337-42.
Ab Raman I, Suhaimi H, Tiddy G. Liquid crystals and microemulsions formed by mixtures of a non-ionic surfactant with palm oil and its derivatives. Advances in Colloid and Interface Science.(2003)106(1-3):109-27.
Siafaka PI, Barmbalexis P, Bikiaris DN. Novel electrospun nanofibrous matrices prepared from poly (lactic acid)/poly (butylene adipate) blends for controlled release formulations of an anti-rheumatoid agent. European Journal of Pharmaceutical Sciences.(2016)88:12-25.
Gradzielski M, Duvail M, de Molina PM, Simon M, Talmon Y, Zemb T. Using microemulsions: formulation based on knowledge of their mesostructure. Chemical Reviews.(2021)121(10):5671-740.
Moghimipour E, Salimi A, Changizi S. Preparation and microstructural characterization of griseofulvin microemulsions using different experimental methods: SAXS and DSC. Advanced Pharmaceutical Bulletin.(2017)7(2):281.
Koosha M, Mirzadeh H. Electrospinning, mechanical properties, and cell behavior study of chitosan/PVA nanofibers. Journal of Biomedical Materials Research Part A.(2015)103(9):3081-93.
Çay A, Miraftab M, Kumbasar EPA. Characterization and swelling performance of physically stabilized electrospun poly (vinyl alcohol)/chitosan nanofibres. European polymer journal.(2014)61:253-62.
Tan ZJ, Zhang X, editors. Influence of chitosan on electrospun PVA nanofiber mat. 2011 International Conference on Advanced Design and Manufacturing Engineering, ADME; 2011: Citeseer.
Moghimipour E, Salimi A, Zadeh BSM. Effect of the various solvents on the in vitro permeability of vitamin B12 through excised rat skin. Tropical Journal of Pharmaceutical Research.(2013)12(5):671-7.
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