Comparing Two Different Doses of Intravenous Midazolamin in Pediatric Sedation and Analgesia
学术急诊医学档案,
卷 4 编号 4 (2016),
1 十一月 2016
,
第 192-195 页
https://doi.org/10.22037/aaem.v4i4.249
摘要
Introduction: Midazolam has turned into a common drug for pediatric procedural sedation and analgesia. However, there is not much data regarding its proper dose and potential side effects in the Iranian children population. Therefore, the present study was done to compare 2 doses of IV midazolam in this regard. Methods: The present clinical trial was performed to compare 0.1 and 0.3 mg/kg doses of IV midazolam in induction of sedation for head trauma infant patients in need of brain computed tomography (CT) scan. Conscious infants under 2 years old, with stable hemodynamics were included. Onset and duration of action as well as probable side effects were compared between the two groups using SPSS version 22. Results: 110 infants with the mean age of 14.0 §5.9 months (range: 4–24) and mean weight of 9.7±2 kg (range: 5–15) were randomly allocated to one of the 2 study groups (54.6% female). Success rate in 0.1 and 0.3 mg /kg groups were 38.2% (21 patients)and 60% (33 patients), respectively (p=0.018). Overall, 56 (50.9%) patients did not reach proper sedation and were sedated receiving ketamine (22 patients) or another dose of midazolam (34 patients, mean additional dose needed was 2.1±1.1 mg). Conclusion: The results of the present study demonstrated the higher success rate and longer duration of action for 0.3 mg /kg midazolam compared to 0.1 mg /kg. The groups were equal regarding onset of action, effect on vital signs and probable side effects.- conscious sedation
- dose-response relationship
- drug
- infant
- emergency service
- hospital
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参考
LGREN JT, ALGREN CL. Sedation and analgesia for minor pediatric procedures. Pediatric emergency care. 1996;12(6):435–41.
Moro-Sutherland DM, Algren JT, Louis PT, Kozinetz CA, Shook JE. Comparison of intravenous midazolam with pentobarbital for sedation for head computed tomography imaging. Academic Emergency Medicine.
;7(12):1370–5.
Thompson J, Schneider S, Ashwal S, Holden B, Hinshaw Jr D, Hasso A. The choice of sedation for computed tomography in children: a prospective evaluation. Radiology. 1982;143(2):475–9.
Yaster M, Nichols DG, Deshpande JK, Wetzel RC. Midazolam-fentanyl intravenous sedation in children: case report of respiratory arrest. Pediatrics. 1990;86(3):463–7.
Sievers TD, Yee JD, Foley ME, Blanding PJ, Berde CB. Midazolam
for conscious sedation during pediatric oncology procedures: safety and recovery parameters. Pediatrics. 1991;88(6):1172–9.
Singh R, Kumar N, Vajifdar H. Midazolam as a sole sedative for computed tomography imaging in pediatric patients. Pediatric Anesthesia. 2009;19(9):899–904.
Ramsay M, Savege T, Simpson B, Goodwin R. Controlled sedation with alphaxalone-alphadolone. British medical journal. 1974;2(5920):656.
Jevdi´c J, Šurbatovi´c M, Drakuli´c-Mileti´c S, Žuni´c F. Deep sedation with midazolam and propofol in children undergoing ambulatory magnetic resonance imaging of the brain. Vojnosanitetski pregled. 2011;68(10):842–5.
Ab Rahman NHN, Hashim A. Is it safe to use propofol in the emergency department? A randomized controlled trial to compare propofol and midazolam. International journal of emergency medicine. 2010;3(2):105–13.
Munro A, Machonochie I. Midazolam or ketamine for procedural sedation of children in the emergency department. Emergency Medicine Journal. 2007;24(8):579–80.
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