Association of High Serum Adiponectin with the Risk of Malnutrition and Worse Outcome in Head Trauma Patients; a Cohort study
Archives of Academic Emergency Medicine,
Vol. 7 No. 1 (2019),
,
Page e43
https://doi.org/10.22037/aaem.v7i1.444
Abstract
Introduction: A number of studies have shown the association between serum adiponectin level and the nutritional status. This study aimed to evaluate the relation between serum adiponectin and changes in nutritional status of head trauma patients.
Methods: The current prospective cohort study was carried out on head trauma patients who were hospitalized in ICU of a General Teaching Hospital, Sulaimani, Iraq. Patients were divided into two groups based on their serum adiponectin level during the first 24 hours of admission (<15mg/L and ≥15 mg/L) and malnutrition and nutritional indices were compared between groups 1, 6 and 13 days after admission.
Results: Sixty-four patients with the mean age of 35.97 ± 11.5 years were studied (59.4% male; 57% traffic accidents). The nutritional status of head trauma patients with serum adiponectin ≥15 mg/L significantly deteriorated from day 1 to 13 based on different nutritional status indices. BMI (p = 0.08), LBM (p = 0.002), APM (p = 0.009), and MUAC (p = 0.008) had a significant decreasing trend from day 1 to day 13 in patients with serum adiponectin level ≥ 15 mg/L. In addition, the number of high risk patients for developing malnutrition based on NUTRIC score (p < 0.001) and the number of severely malnourished cases based on SGA score (p < 0.001) significantly increased from day 1 to 13 in this group. The severity of disease based on APACHE (p < 0.001) and SOFA (p < 0.001) scores increased in the mentioned cases during the follow up period.
Conclusion: Serum adiponectin level ≥ 15 is associated with significant deterioration in nutritional status, increase in the risk of malnutrition, and worsening of the clinical outcome in patients with moderate to severe head trauma in ICU.
- Adiponectin
- craniocerebral trauma
- body composition
- APACHE
- organ dysfunction scores
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References
Ahima RS, Osei SY. Adipokines in obesity. Obesity and Metabolism. 36: Karger Publishers; 2008. p. 182-97.
Karmiris K, Koutroubakis IE, Xidakis C, Polychronaki M, Voudouri T, Kouroumalis EA. Circulating levels of leptin, adiponectin, resistin, and ghrelin in inflammatory bowel disease. Inflammatory bowel diseases. 2006;12(2):100-5.
Marousi S, Theodorou G, Karakantza M, Papathanasopoulos P, Ellul J. Serum adiponectin acutely after an ischemic stroke: implications for a longâ€lasting, suppressed antiâ€inflammatory role. Acta neurologica scandinavica. 2010;121(4):277-84.
Dekker JM, Funahashi T, Nijpels G, Pilz S, Stehouwer CD, Snijder MB, et al. Prognostic value of adiponectin for cardiovascular disease and mortality. The Journal of Clinical Endocrinology & Metabolism. 2008;93(4):1489-96.
Shen L-J, Yang S-B, Lv Q-W, Zhang G-H, Zhou J, Guo M, et al. High plasma adiponectin levels in patients with severe traumatic brain injury. Clinica Chimica Acta. 2014;427:37-41.
Ekramzadeh M, Sohrabi Z, Salehi M, Ayatollahi M, Hassanzadeh J, Geramizadeh B, et al. Adiponectin as a novel indicator of malnutrition and inflammation in hemodialysis patients. Iranian journal of kidney diseases. 2013;7(4).
McEntegart MB, Awede B, Petrie MC, Sattar N, Dunn FG, MacFarlane NG, et al. Increase in serum adiponectin concentration in patients with heart failure and cachexia: relationship with leptin, other cytokines, and B-type natriuretic peptide. European heart journal. 2007;28(7):829-35.
Fruebis J, Tsao T-S, Javorschi S, Ebbets-Reed D, Erickson MRS, Yen FT, et al. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proceedings of the National Academy of Sciences. 2001;98(4):2005-10.
Hyun YY, Lee K-B, Oh K-H, Ahn C, Park SK, Chae DW, et al. Serum adiponectin and protein–energy wasting in predialysis chronic kidney disease. Nutrition. 2017;33:254-60.
Dervisoglu E, Eraldemir C, Kalender B, Kir HM, Caglayan C. Adipocytokines leptin and adiponectin, and measures of malnutrition-inflammation in chronic renal failure: is there a relationship? Journal of renal nutrition. 2008;18(4):332-7.
Iwahashi H, Funahashi T, Kurokawa N, Sayama K, Fukuda E, Okita K, et al. Plasma adiponectin levels in women with anorexia nervosa. Hormone and Metabolic Research. 2003;35(09):537-40.
Chandran M, Phillips SA, Ciaraldi T, Henry RR. Adiponectin: more than just another fat cell hormone? Diabetes care. 2003;26(8):2442-50.
Wolfe BE, Jimerson DC, Orlova C, Mantzoros CS. Effect of dieting on plasma leptin, soluble leptin receptor, adiponectin and resistin levels in healthy volunteers. Clinical endocrinology. 2004;61(3):332-8.
Wang W-H, Yu W-H, Dong X-Q, Zhang Z-Y, Zhu Q, Che Z-H, et al. Plasma adiponectin as an independent predictor of early death after acute intracerebral hemorrhage. Clinica Chimica Acta. 2011;412(17-18):1626-31.
Walkey AJ, Rice TW, Konter J, Ouchi N, Shibata R, Walsh K, et al. Plasma adiponectin and mortality in critically ill subjects with acute respiratory failure. Critical care medicine. 2010;38(12):2329.
Schnabel R, Messow CM, Lubos E, Espinola-Klein C, Rupprecht HJ, Bickel C, et al. Association of adiponectin with adverse outcome in coronary artery disease patients: results from the Athero Gene study. European heart journal. 2008;29(5):649-57.
Finfer SR, Cohen J. Severe traumatic brain injury. Resuscitation. 2001;48(1):77-90.
Mussack T, Biberthaler P, Kanz K-G, Wiedemann E, Gippner-Steppert C, Mutschler W, et al. Serum S-100B and interleukin-8 as predictive markers for comparative neurologic outcome analysis of patients after cardiac arrest and severe traumatic brain injury. Critical care medicine. 2002;30(12):2669-74.
Kadowaki T, Yamauchi T. Adiponectin and adiponectin receptors. Endocrine reviews. 2005;26(3):439-51.
Ouchi N, Walsh K. Adiponectin as an anti-inflammatory factor. Clinica chimica acta. 2007;380(1-2):24-30.
Huang J, Upadhyay UM, Tamargo RJ. Inflammation in stroke and focal cerebral ischemia. Surgical neurology. 2006;66(3):232-45.
Flögel U, Ding Z, Hardung H, Jander S, Reichmann G, Jacoby C, et al. In vivo monitoring of inflammation after cardiac and cerebral ischemia by 19F magnetic resonance imaging. Circulation. 2008;118(2):140.
Shibata R, Sato K, Kumada M, Izumiya Y, Sonoda M, Kihara S, et al. Adiponectin accumulates in myocardial tissue that has been damaged by ischemia-reperfusion injury via leakage from the vascular compartment. Cardiovascular research. 2007;74(3):471-9.
Chen B, Liao W-Q, Xu N, Xu H, Wen J-Y, Yu C-A, et al. Adiponectin protects against cerebral ischemia–reperfusion injury through anti-inflammatory action. Brain research. 2009;1273:129-37.
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