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Vol. 2 No. 2 (2014)

May 2014

The Risk of Venous Thromboembolism Associated with Oral Contraceptive; the Search Is Still On

  • Ali Abdalvand

Archives of Academic Emergency Medicine, Vol. 2 No. 2 (2014), 1 May 2014 , Page 53
https://doi.org/10.22037/aaem.v2i2.27 Published: 2018-11-14

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Abstract

A few years after coming to the market, the first generation of oral contraceptive pills (OCPs) were linked to significant risk of venous thromboembolism (VTE). This increased risk was blamed on the presence of the estrogen-like compounds in these agents. Therefore, the efforts were initiated to decrease the VTE risk of OCPs by lowering the delivered estrogen content by adding progestins such as levonorgestrel to these products, which led to production of the second generation of OCPs. Thereafter, the third generation of these agents with lower doses of progesterone-like compounds with contraceptive efficacy was released. They contain the new progestins such as Drospirenone, Norgestimate, Desogestrel and Gestodene (1-3).

 

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1.
Abdalvand A. The Risk of Venous Thromboembolism Associated with Oral Contraceptive; the Search Is Still On. Arch Acad Emerg Med [Internet]. 2018 Nov. 14 [cited 2025 May 22];2(2):53. Available from: https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/27
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References

Rott H. Thrombotic risks of oral contraceptives. Curr Opin Obstet Gynecol. 2012;24(4):235-40.

Manzoli L, De Vito C, Marzuillo C, Boccia A, Villari P. Oral Contraceptives and Venous Thromboembolism. Drug Saf. 2012;35(3):191-205.

Peck R, Norris C. Significant Risks of Oral Contraceptives (OCPs): Why This Drug Class Should Not Be Included in a Preventive Care Mandate. Linacre Q. 2012;79(1):41-56.

Baratloo A, Safari S, Rouhipour A, et al. The Risk of Venous Thromboembolism with Different Generation of Oral Contra-ceptives; a Systematic Review and Meta-Analysis. Emergency. 2014;2(1):1-11.

Martínez F, Ramírez I, Pérez-Campos E, Latorre K, Lete I. Venous and pulmonary thromboembolism and combined ho-rmonal contraceptives. Systematic review and meta-analysis. Eur J Contracept Reprod Health Care. 2012;17(1):7-29.

Gronich N, Lavi I, Rennert G. Higher risk of venous thromb-osis associated with drospirenone-containing oral contrace-ptives: a population-based cohort study. Can Med Assoc J. 2011;183(18):E1319-E25.

Parkin L, Sharples K, Hernandez RK, Jick SS. Risk of venous thromboembolism in users of oral contraceptives containing drospirenone or levonorgestrel: nested case-control study based on UK General Practice Research Database. BMJ. 2011;342:d2139.

Dinger J, Assmann A, Möhner S, Do Minh T. Risk of venous thromboembolism and the use of dienogest-and drospire-none-containing oral contraceptives: results from a German case-control study. J Fam Plann Reprod Health Care. 2010;36 (3):123-9.

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