Acellular Fish Skin for Deep Dermal Traumatic Wounds Management; Introducing a Novel Dressing
Archives of Academic Emergency Medicine,
Vol. 12 No. 1 (2024),
1 January 2024
,
Page e14
https://doi.org/10.22037/aaem.v12i1.2103
Abstract
The optimal therapy for deep wounds is based on the early debridement of necrotic tissue followed by wound coverage to avoid a systemic inflammatory response and optimize scar-free healing. The outcomes are affected by available resources and underlying patient factors, which cause challenges in wound care and suboptimal outcomes.
Here we report a patient with deep dermal injury wounds, who was treated with platelet-rich fibrin (PRF) gel, plasma rich in growth factor (PRGF) gel, and acellular fish skin. Patient’s outcomes regarding healing and scar quality were collected objectively and subjectively for one year after the injury. Wounds treated with acellular fish skin demonstrated accelerated wound healing, a significantly higher water-storage capacity, and better pain relief. Furthermore, improved functional and cosmetic outcomes, such as elasticity, skin thickness, and pigmentation, were demonstrated. It seems that, the PRGF gel and PRF in combination with acellular fish skin grafts resulted in the faster healing of wounds and better functional and aesthetic outcomes than split-thickness skin grafts treatment.
- Wound healing
- platelet-rich fibrin
- Transplantation, heterologous
How to Cite
References
Lee KC, Joory K, Moiemen NS. History of burns: the past, present and the future. Burns & trauma. 2014;2(4):2321-3868.143620.
Wallner C, Wagner J, Dittfeld S, Drysch M, Lehnhardt M, Behr B. Myostatin serum concentration as an indicator for deviated muscle metabolism in severe burn injuries. Scandinavian Journal of Surgery. 2019;108(4):297-304.
Wallner C, Huber J, Drysch M, Schmidt SV, Wagner JM, Dadras M, et al. Myostatin upregulation in patients in the chronic phase of severe burn injury leads to muscle cell catabolism. European Surgical Research. 2019;60(1-2):86-96.
Kirsner RS, Margolis DJ, Baldursson BT, Petursdottir K, Davidsson OB, Weir D, et al. Fish skin grafts compared to human amnion/chorion membrane allografts: a double‐blind, prospective, randomized clinical trial of acute wound healing. Wound repair and regeneration. 2020;28(1):75-80.
Lee KC, Dretzke J, Grover L, Logan A, Moiemen N. A systematic review of objective burn scar measurements. Burns & trauma. 2016;4.
Kamalvand M, Biazar E, Daliri-Joupari M, Montazer F, Rezaei-Tavirani M, Heidari-Keshel S. Design of a decellularized fish skin as a biological scaffold for skin tissue regeneration. Tissue and Cell. 2021;71:101509.
Diller RB, Tabor AJ. The role of the extracellular matrix (ECM) in wound healing: A review. Biomimetics. 2022;7(3):87.
Rennert RC, Sorkin M, Garg RK, Januszyk M, Gurtner GC. Cellular response to a novel fetal acellular collagen matrix: implications for tissue regeneration. International journal of biomaterials. 2013;2013.
Cornwell KG, Landsman A, James KS. Extracellular matrix biomaterials for soft tissue repair. Clinics in podiatric medicine and surgery. 2009;26(4):507-23.
Rizzi SC, Upton Z, Bott K, Dargaville TR. Recent advances in dermal wound healing: biomedical device approaches. Expert review of medical devices. 2010;7(1):143-54.
Larson BJ, Longaker MT, Lorenz HP. Scarless fetal wound healing: a basic science review. Plastic and reconstructive surgery. 2010;126(4):1172.
Alam K, Jeffery SL. Acellular fish skin grafts for management of split thickness donor sites and partial thickness burns: a case series. Military medicine. 2019;184(Supplement_1):16-20.
Biazar E, Heidari Keshel S, Rezaei Tavirani M, Kamalvand M. Healing effect of acellular fish skin with plasma rich in growth factor on full‐thickness skin defects. International Wound Journal. 2022;19(8):2154-62.
Magnusson S, Kjartansson H, Baldursson BT, Astradsdottir K, Ågren MS, Hilmarsson H, et al. Acellular fish skin grafts and pig urinary bladder matrix assessed in the collagen-induced arthritis mouse model. The International Journal of Lower Extremity Wounds. 2018;17(4):275-81.
Chicharro-Alcántara D, Rubio-Zaragoza M, Damiá-Giménez E, Carrillo-Poveda JM, Cuervo-Serrato B, Peláez-Gorrea P, et al. Platelet rich plasma: new insights for cutaneous wound healing management. Journal of functional biomaterials. 2018;9(1):10.
De Vos R, Van Veldhoven P, Moen M, Weir A, Tol J, Maffulli N. Autologous growth factor injections in chronic tendinopathy: a systematic review. British medical bulletin. 2010;95(1):63-77.
Bayer A, Wijaya B, Möbus L, Rademacher F, Rodewald M, Tohidnezhad M, et al. Platelet-released growth factors and platelet-rich fibrin induce expression of factors involved in extracellular matrix organization in human keratinocytes. International journal of molecular sciences. 2020;21(12):4404.
Molina‐Miñano F, López‐Jornet P, Camacho‐Alonso F, Vicente‐Ortega V. The use of plasma rich in growth factors on wound healing in the skin: experimental study in rabbits. International wound journal. 2009;6(2):145-8.
Jornet MPL, Alonso FC, Miñano FM, Ortega VV. Effects of plasma rich in growth factors on wound healing of the tongue. Experimental study in rabbits. Medicina oral, patología oral y cirugía bucal Ed inglesa. 2009;14(9):3.
Chen J, Gao K, Liu S, Wang S, Elango J, Bao B, et al. Fish collagen surgical compress repairing characteristics on wound healing process in vivo. Marine drugs. 2019;17(1):33.
Costa BA, Lima Júnior EM, de Moraes Filho MO, Fechine FV, de Moraes MEA, Silva Júnior FR, et al. Use of tilapia skin as a xenograft for pediatric burn treatment: a case report. Journal of burn care & research. 2019;40(5):714-7.
Lima Júnior EM, De Moraes Filho MO, Costa BA, Rohleder AVP, Sales Rocha MB, Fechine FV, et al. Innovative burn treatment using tilapia skin as a xenograft: a phase II randomized controlled trial. Journal of Burn Care & Research. 2020;41(3):585-92.
Fiakos G, Kuang Z, Lo E. Improved skin regeneration with acellular fish skin grafts. Engineered Regeneration. 2020;1:95-101.
- Abstract Viewed: 305 times
- pdf Downloaded: 1013 times