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Archives of Academic Emergency Medicine

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  4. Original/Research Article

Vol. 9 No. 1 (2021)

January 2021

Fibrinogen Dysregulation is a Prominent Process in Fatal Conditions of COVID-19 Infection; a Proteomic Analysis

  • Mostafa Rezaei-Tavirani
  • Mohammad Rostami Nejad
  • Babak Arjmand
  • Sina Rezaei Tavirani
  • Mohammadreza Razzaghi
  • Vahid Mansouri

Archives of Academic Emergency Medicine, Vol. 9 No. 1 (2021), 1 January 2021 , Page e26
https://doi.org/10.22037/aaem.v9i1.1128 Published: 2021-03-15

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Abstract

Introduction: Molecular pathophysiology of COVID-19 is not completely known. Expression changes in patients' plasma proteins have revealed new information about the disease. Introducing the key targeted plasma protein in fatal conditions of COVID-19 infection is the aim of this study.

Methods: Significant differentially expressed proteins (DEPs) in the plasma of cases with a fatal condition of COVID-19 were extracted from an original article. These proteins were included in a network via STRING database along with 100 first neighbor proteins to determine central nodes of the network for analyzing.

Results: Queried and added proteins were included in a scale free network. Three hub nodes were identified as critical target proteins. The top queried hub proteins were chains of fibrinogen; Fibrinogen Alpha chain (FGA), Fibrinogen gamma chain (FGG), and Fibrinogen beta chain (FGB), which are related to the coagulation process.

Conclusions: It seems that fibrinogen dysregulation has a deep impact on the fatality of COVID-19 infection.

Keywords:
  • SARS-CoV-2
  • Proteomics
  • Proteins
  • Protein Interaction Maps
  • Fibrinogen
  • pdf

How to Cite

1.
Rezaei-Tavirani M, Rostami Nejad M, Arjmand B, Rezaei Tavirani S, Razzaghi M, Mansouri V. Fibrinogen Dysregulation is a Prominent Process in Fatal Conditions of COVID-19 Infection; a Proteomic Analysis. Arch Acad Emerg Med [Internet]. 2021 Mar. 15 [cited 2025 May 19];9(1):e26. Available from: https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/1128
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