Association of Transforming Growth Factor-β1 rs1982073 Polymorphism with Susceptibility to Acute Renal Rejection: a Systematic Review and Meta-Analysis
Vol. 18 No. 01 (2021),
Purpose: The association of rs1982073 (codon 10) polymorphism at Transforming Growth Factor- β1 (TGF-β1)
gene with acute renal rejection (ARR) has been reported by several studies. However, the results were controversial. To derive a more precise estimation of this association, a meta-analysis was performed.
Methods: The eligible literatures were identified through PubMed, Scopus, Web of Science, EMBASE, SciELO,
WanFang, and CNKI databases up to July 01, 2019. The pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to calculate the strength of the association.
Results: A total of 23 case-control studies with 795 ARR cases and 1,562 non-AR controls were selected. Pooled
data revealed that there was no significant association between TGF-β1 codon 10 polymorphism and an increased risk of ARR in the overall population (C vs. T: OR=0.908, 95% CI 0.750-1.099, p = 0.322; CT vs. TT: OR=1.074, 95% CI 0.869-1.328, p = 0.507; CC vs.TT: OR=0.509, 95% CI=0.738-1.253, p = 0.770; CC+CT vs. TT: OR =
0.917, 95% CI 0.756-1.112, p = 0.376, and CC vs. CT+TT: OR=0.995, 95% CI 0.809-1.223, p = 0.959). Moreover,
stratified analysis revealed no significant association between the TGF-β1 rs1982073 polymorphism and ARR
risk by ethnicity and cases type (recipient and donor).
Conclusion: The current meta-analysis demonstrated that the TGF-β1 rs1982073 polymorphism was not significantly
associated with increased risk of ARR. However, studies with a larger number of subjects among different
ethnic groups are needed to further validate the results.