Williams-Beuren Syndrome: Manifestation with Attention Deficit Hyper Activity Disorder and Voiding Dysfunction with Kidney Anomalies; Good Response to Ritalin
Journal of Pediatric Nephrology,
Vol. 3 No. 3 (2015),
Williams-Beuren syndrome is a rare neurodevelopmental disease, in which mental retardation is common with this submicroscopic chromosomal deletion genetically disease.
We reported a boy with Williams-Beuren syndrome and highlighted the clinical characteristics and response to treatment with Ritaline of such an individual with ADHD and voiding dysfunction.
The patient was a six year-old boy with typical presentation of WBS and some psychiatric problems referred because of hyperactivity symptom and attention deficit.
Children with mental retardation and WBS have a comorbidity of psychiatric disorders and kidney anomalies.
Williams-Beuren syndrome can present with hyperactivity and Ritalin can improve some symptoms and voiding dysfunction.Keywords: Williams-Beuren Syndrome; Attention Deficit Disorder with Hyperactivity; Ritalin; Methylphenidate.
How to Cite
Williams JC, Barratt-Boyes BG, Lowe JB. Supravalvular aortic stenosis.Circulation 1961:1311-8.
Beuren AJ. Supravalvular aortic stenosis: a complex syndrome with andwithout mental retardation. Birth Defects Orig Art Ser VIII 1972: 45-56.
Ewart AK, Morris CA, Atkinson D, Jin W, Sternes K, Spallone P, et al.Hemizygosity at the elastin locus in a developmental disorder, Williamssyndrome. Nat Genet 1993; 5:11-6.
Rhodes SM, Riby DM, Matthews K, Coghill DR. Attention-deficit/hyperactivity disorder and Williams syndrome: shared behavioral and neuropsychological profiles. J Clin Exp Neuropsychol.2011; 33(1):147-56.
Stromme P, Bjornstad PG, Ramstad K. Prevalence estimation of Williams syndrome.J Child Neurol. 2002; 17(4):269-71.
Singh NN, Sood A, Sonenklar N, Ellis CR. Assessment and diagnosis of mental illness in persons with mental retardation. Behav Mod 1991; 15:419-43.
Pober BR, Lacro RV, Rice C, Mandell V, Teele RL. Renal findings in 40 individuals with Williams syndrome. Am J Med Genet. 1993; 46(3):271-4.
Pankau R, Partsch CJ, Winter M, Gosch A, Wessel A. Incidence and spectrum of renal abnormalities in Williams-Beuren syndrome. Am J Med Genet. 1996; 63(1):301-4.
Sammour ZM, Gomes CM, Duarte RJ, Trigo-Rocha FE, Srougi M. Voiding dysfunction and the Williams-Beuren syndrome: a clinical and urodynamic investigation. J Urol. 2006; 175(4):1472-6.
Duel BP, Steinberg-Epstein R, Hill M, Lerner M. A survey of voiding dysfunction in children with attention deficit-hyperactivity disorder.J Urol. 2003; 170(4 Pt 2):1521-3; discussion 1523-4.
Lashkari A, Smith AK, Graham JM, Jr. Williams-Beuren syndrome: an update and review for the primary physician Clin Pediatr 1999; 38:189-208.
Janet C. Kennedy, David L. Kaye, Laurie S. Sadler. Psychiatric Diagnoses in Patients with Williams Syndrome and Their Families. Jefferson Journal of Psychiatry 2006; 20(1): 22-31.
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