Prenatal Risk Factors for Infantile Reflux Nephropathy
Journal of Pediatric Nephrology,
Vol. 3 No. 4 (2015),
26 September 2015
,
Page 135-138
https://doi.org/10.22037/jpn.v3i4.8302
Abstract
Introduction: Vesicoureteral reflux (VUR) refers to the retrograde flow of the urine from the bladder to the ureter and kidney. In children with a febrile urinary tract infection (UTI), those with reflux are 3 times more likely to develop renal injury compared to those without reflux. Reflux nephropathy was once accounted for as much as 15-20% of end-stage renal disease in children and young adults. With greater attention to the management of UTIs and a better understanding of reflux, end-stage renal disease secondary to reflux nephropathy is uncommon. Reflux nephropathy remains one of the most common causes of hypertension in children. Reflux in the absence of infection or elevated bladder pressure does not cause renal injury. We sought to determine the association of infantile reflux nephropathy (IRN) with prenatal risk factors.
Materials and Methods: In this study, 96 infants with reflux-related renal injury and 96 infants with VUR without reflux nephropathy were evaluated. Maternal information was assessed. Data was analyzed using SPSS version 18.
Results: The results of this study showed that age more than 35 years, pre-gestational hypertension, preeclampsia and eclampsia, preterm delivery, very low birth weight (VLBW), pre gestational diabetes mellitus, and maternal BMI<18.5kg/m2 (underweight) were prenatal risk factors for infantile reflux nephropathy.
Conclusions: The data suggests that prenatal factors may affect the risk of IRN. Adequate prenatal care and good maternal support can be effective in the prevention of reflux-related renal injury.
Keywords: Vesico-Ureteral Reflux; Risk Factors; Prenatal; Infant.
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References
Yousefichaijan P, Rafiei M, Eghbali A, et al. Mean Platelet Volume: A useful marker ln reflux nephropathy. J Ped. Nephrology 2014;2(4):137-139.
Yousefichaijan P, Cyrus A, Dorreh F, et al. Correlation of sacral ratio and reflux–related renal injury in children with and without nephropathy. J Ped. Nephrology 2014;2 (3): 116-118.
Jack S.Elder, Vesicoureteral Reflux. Kliegman, Stanton, St. Geme, Schor, Behrman. Nelson Textbook of Pediatric 19th edition, Elsevier Saunders, 2011 chapter 533, P:1834-46.
Yousefichaijan P, Cyrus A, Dorreh F, Ahmadi Mohtasham M. Comparing the sacral ratio in children with various degree of Vesicoureteral reflux with children without reflux. AMUJ 2005;10(3):94-99.
Yousefichaijan P, Cyrus A, Dorreh F. Sacrum index in children suffering from different grades of VUR .Pakistan journal of biological sciences 2013;16(11):545-547.
Yousefichaijan P, Dorreh F. Effect factors in growth and development in children and infants with VUR. Medical Journal of Mashhad University of medical sciences 2014;l57(5):690-696.
Christine W. Hsu, Kalani T. Yamamoto, Rohan K. Henry, Anneclaire J. De Roos, Joseph T. Flynn. Prenatal Risk Factors for Childhood CKD. JASN 2014;April 17.
Sokal R, Tata LJ, Fleming KM. Sex prevalence of major congenital anomalies in the United Kingdom: a national population-based study and international comparison meta-analysis. Birth Defects Res A ClinMolTeratol 2014;100(2):79-91.
Räisänen S, Sankilampi U, Gissler M, et al. Smoking cessation in the first trimester reduces most obstetric risks, but not the risks of major congenital anomalies and admission to neonatal care: a population-based cohort study of 1,164,953 singleton pregnancies in Finland. J Epidemiol Community Health. 2014;68(2):159-64.
Sheridan E, Wright J, Small N, et al. Risk factors for congenital anomaly in a multiethnic birth cohort: an analysis of the Born in Bradford study. Lancet 2013;19;382(9901):1350-9.
Retnakaran R, Kramer CK, Ye C, Kew S, et al. Fetal Sex and Maternal Risk of Gestational Diabetes Mellitus: The Impact of Having a Boy. Diabetes Care 2015 Feb 18.
Robert H. Mak, Franz Schaefer. Chronic kidney disease: Prenatal risk factors for kidney and urinary tract anomalies. Nature Reviews Nephrology Nature Reviews Nephrology 2014;17(10):428–429.
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