Amikacin-induced Nephrotoxicity in a Child with Idiopathic Nephrotic Syndrome in Iran: A Case Report
Journal of Pediatric Nephrology,
Vol. 3 No. 1 (2015),
10 January 2015
,
Page 31-34
https://doi.org/10.22037/jpn.v3i1.7284
Abstract
We report an unusual case of Amikacin-induced nephrotoxicity in a child. The patient was a seven and a half year old girl with nephrotic syndrome and cushingoid facial features who was referred to Tehran Children's Medical Center for renal biopsy so as to start cyclosporine therapy for the diagnosis of disease recurrence. Before coming to our center she was admitted to another hospital with complaints of severe abdominal pain and vomiting. In the course of hospitalization in our center, the patient gradually became oliguric and her serum creatinine increased from 0.3 mg/dl to 3.5 mg/dl. During her previous hospitalization about 2 weeks ago, use of amikacin and ceftriaxone was found. There were several reasons for kidney failure in the child, one of which was possibility of amikacin-induced nephrotoxicity. A renal biopsy showed diffuse mesangial proliferative and tubular lesions, which were in favor of amikacin toxicity. It seems that Amikacin can lead to nephrotoxicity if the patient is dehydrated and experiencing reduction of effective vascular volume. Regarding logical use of amikacin,renal function should be monitored regularly.
Keywords: Acute Tubular Necrosis; Acute Renal Failure; Acute Tubulointerstitial Nephritis; Nephrotic Syndrome; Amikacin; Iran.
How to Cite
References
Printza N, Koukourgianni F, Saleh T, Goga C, Papachristou F. Drug-induced interstitial nephritis in a child with idiopathic nephrotic syndrome. Saudi J Kidney Dis Transpl 2009;20(6):1072-5.
Chatzikyrkou C, Hamwi I, Clajus C, Becker J, Hafer C, Kielstein JT. Biopsy proven acute interstitial nephritis after treatment with moxifloxacin. BMC Nephrol 2010;23;11:19. doi:10.1186/1471-2369-11-19.
Van der Meulen J, De Jong GM, Westenend PJ. Acute interstitial nephritis during rifampicin therapy can be a paradoxical response: a case report. Cases J 2009;3;2:6643. doi:10.1186/1757-1626-0002-0000006643.
Vogelstein B, Kowarski A.A., Lietman P.S. The pharmacokinetics of amikacin in children. The Journal of pediatrics 1977;91(2):333-339.
Bennett WM, Wood CA, Houghton DC, Gilbert DN. Modification of experimental aminoglycoside nephrotoxicity. American J of Kidney Dis 1986; 8:292-6.
Perazella MA, Markowitz GS. Drug-induced acute interstitial nephritis. Nat Rev Nephrol 2010; 6(8):461-70. doi:10.1038/nrneph.2010.71.
Hoppes T, Prikis M, Segal A. Four cases of nafcillin-associated acute interstitial nephritis in one institution. Nat Clin Pract Nephrol 2007;3(8):456-61.
Sandhu JS, Sehgal A, Gupta O and Singh A, Aminoglycoside nephrotoxicity revisited. J Indian Acad Clin Med 2007;8(4): 331-333.
Eslami1 G, Salehifar E, Behbudi M, Rezai MS. Rational Use of Amikacin in Buali-Sina Hospital in Sari, 2011. J Mazand Univ Med Sci 2013; 23(100):2-9 (Persian).
- Abstract Viewed: 340 times
- PDF Downloaded: 279 times