The Role of Omega-3 in Improving Clinical Symptoms of Children With Urinary Tract Infections: A Randomized Clinical Trial Omega-3 in Children With Urinary Tract Infections
Journal of Pediatric Nephrology,
Vol. 12 No. 1 (2024),
10 April 2025
https://doi.org/10.22037/jpn.v12i1.47226
Abstract
Background and Aim: Inflammatory urinary tract infection (UTI) is a common infectious
disease in childhood, causing significant discomfort. Omega-3 fatty acids are well-known for
their anti-inflammatory properties, which may aid in decreasing UTI symptoms. This study
aimed to investigate the effects of omega-3 therapy in children with UTI.
Methods: This randomized clinical trial enrolled 100 children with UTIs, randomized into
placebo and intervention groups. In addition to standard treatment, the intervention group
received one omega-3 capsule daily. Symptoms were assessed at the baseline and again after
the treatment period.
Results: At baseline, no significant differences were observed between the two groups
in age, gender, or symptom prevalence. However, after the treatment period, omega-3
supplementation resulted in a significant decrease in dysuria and urinary frequency symptoms
compared to the placebo group.
Conclusion: Omega-3 supplementation as adjunct therapy can significantly improve the
severity of symptoms in children with UTIs.
- Urinary tract infection
- Omega-3
- Inflammation
- children
How to Cite
References
[1] Tullus K, Shaikh N. Urinary tract infections in children.
Lancet. 2020; 395(10237):1659-68. [DOI:10.1016/S0140-
6736(20)30676-0] [PMID]
[2] Jiang J, Chen XY, Guo H. Clinical characteristics and nomogram
model for predicting the risk of recurrence of complicated
urinary tract infection in pediatric patients. Sci Rep. 2024;
14(1):25393. [DOI:10.1038/s41598-024-76901-0] [PMID]
[3] Oliveira EA, Mak RH. Urinary tract infection in pediatrics:
an overview. J Pediatr. 2020; 96:65-79. [DOI:10.1016/j.
jped.2019.10.006]
[4] Zhou Y, Zhou Z, Zheng L, Gong Z, Li Y, Jin Y, et al. Urinary
tract infections caused by uropathogenic Escherichia coli:
Mechanisms of infection and treatment options. Int J Mol Sci.
2023; 24(13):10537. [DOI:10.3390/ijms241310537] [PMID]
[5] Kavyani Z, Musazadeh V, Fathi S, Hossein Faghfouri A,
Dehghan P, Sarmadi B. Efficacy of the omega-3 fatty acids
supplementation on inflammatory biomarkers: An umbrella
meta-analysis. Int Immunopharmacol. 2022; 111:109104.
[DOI:10.1016/j.intimp.2022.109104] [PMID]
[6] Moslemi E, Musazadeh V, Kavyani Z, Naghsh N, Shoura
SMS, Dehghan P. Efficacy of vitamin D supplementation as
an adjunct therapy for improving inflammatory and oxidative
stress biomarkers: An umbrella meta-analysis. Pharmacol Res.
2022; 186:106484. [DOI:10.1016/j.phrs.2022.106484] [PMID]
[7] Yousefichaijan P, Rezagholizamenjany M, Kahbazi M, Rafiei
M, Taherahmadi H, Kaviani P, et al. The effect of vitamin A
on clinical manifestations of recurrent pyelonephritis in children.
Nephro Urol Mon. 2020; 12(3):e103278. [DOI:10.5812/
numonthly.103278]
[8] Kahbazi M, Sharafkhah M, Yousefichaijan P, Taherahmadi
H, Rafiei M, Kaviani P, et al. Vitamin A supplementation is
effective for improving the clinical symptoms of urinary tract
infections and reducing renal scarring in girls with acute pyelonephritis:
A randomized, double-blind placebo-controlled,
clinical trial study. Complement Ther Med. 2019; 42:429-437.
[DOI:10.1016/j.ctim.2018.12.007] [PMID]
[9] Yousefichaijan P, Kahbazi M, Rasti S, Rafeie M, Sharafkhah M.
Vitamin E as adjuvant treatment for urinary tract infection in girls
with acute pyelonephritis. Iran J Kidney Dis. 2015; 9(2):97. [Link]
[10] Tamma SM, Shorter B, Toh KL, Moldwin R, Gordon B.
Influence of polyunsaturated fatty acids on urologic inflammation.
Int Urol Nephrol. 2015; 47(11):1753-61. [DOI:10.1007/
s11255-015-1108-8] [PMID]
[11] Sedighi I, Taheri-Moghadam G, Emad-Momtaz H, Vaseghi
G, Eshraghi A, Asnaashari F, et al. Protective effects of omega-
3 fatty acids supplementation against renal parenchymal
scarring in children with acute pyelonephritis: Results of a
pilot clinical trial. Curr Pediatr Rev. 2022; 18(1):72-81. [DOI:10
.2174/1573396317666210909153643] [PMID]
[12] Du Y, Sui X, Bai Y, Shi Z, Liu B, Zheng Z, et al. Dietary
influences on urinary tract infections: Unraveling the gut
microbiota connection. Food Funct. 2024; 15(19):10099-109.
[DOI:10.1039/D4FO03271C] [PMID]
[13] Rahmani E, Eftekhari MH, Fallahzadeh MH, Fararouei
M, Massoumi SJ. Effect of vitamin D and omega-3 on nocturnal
enuresis of 7-15-year-old children. J Pediatr Urol.
2018; 14(3):257.e1-257.e6. [DOI:10.1016/j.jpurol.2018.01.007]
[PMID]
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