Lipid Profile of Children With Nephrotic Syndrome Admitted to a Tertiary Care Hospital Lipid Profile in Nephrotic Syndrome
Journal of Pediatric Nephrology,
Vol. 12 No. 1 (2024),
10 Farvardin 2025
https://doi.org/10.22037/jpn.v12i1.46917
Abstract
Background and Aim: Hyperlipidemia is typically detected in active nephrotic syndrome
(NS) and normalizes with the resolution of the proteinuria. This study assessed the lipid
profile of children with NS during active disease and remission.
Methods: This prospective observational study was conducted at ICMH, Bangladesh, from
July 2021 to June 2022. Sixty children with NS (1-18 years), including both first attack and
relapse cases, were enrolled. A detailed history and thorough clinical examination were carried
out. Serum fasting lipid profiles were measured during active disease and again 4 weeks
after achieving remission. After collecting all the required data, analysis was conducted using
SPSS software, version 24.0.
Results: The majority of children (70%) were relapse cases. The mean age of the study
participants was 5.15±2.97 years, with a predominance of males (61.7%). Mean serum
cholesterol, low-density lipoprotein (LDL), and triglycerides (TG) levels were elevated in
all groups, while high-density lipoprotein (HDL) levels were normal in all groups during
active disease. During remission, serum cholesterol, TG, and LDL levels were significantly
reduced in both first attack and relapse cases. LDL levels returned to normal in all groups,
but total cholesterol (TC) and TG remained high in the frequently relapsing NS (FRNS) and
steroid-dependent NS (SDNS) groups. Serum albumin levels were low in all groups, with
significantly lower levels observed in the FRNS group.
Conclusion: During active disease, serum cholesterol, TG, and LDL levels were elevated in
both first attack and relapse cases. Serum TC and TG remained persistently high in FRNS
and SDNS.
- Nephrotic syndrome (NS)
- Hyperlipidemia
- Lipid profile
How to Cite
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