Investigating the Impact of Vitamin E on Acute Kidney Injury Prevention in Leukemia Patients Treated With Vincristine: A Randomized Clinical Trial
Journal of Pediatric Nephrology,
Vol. 12 No. 1 (2024),
10 April 2025
https://doi.org/10.22037/jpn.v12i1.45705
Abstract
Background and Aim:Chemotherapy plays an essential role in the treatment of hematologic
cancers. Vincristine is commonly used to treat leukemia in children. However, this drug has
many side effects, including acute kidney injury (AKI). Adjuvant therapy with antioxidant
agents, such as vitamin E, can be administered to reduce this complication
Methods: A randomized clinical trial of leukemia patients receiving vincristine was conducted
at Amir Kabir Arak Hospital. The patients were randomly divided into an intervention group
(400 mg vitamin E for ten days) and a control group. Creatinine levels, glomerular filtration
rate (GFR), and acute kidney injury were measured at baseline, 48 h, and seven days later.
Independent t-test and chi-square were used to compare data.
Objectives: This study aims to investigate the potential effect of vitamin E supplementation in
reducing acute kidney injury associated with vincristine treatment in patients with leukemia.
Results: Thirty-six children with leukemia, 47.2% of whom were girls, were equally divided
into intervention and control groups. The essential characteristics of the two groups were
not significantly different. The creatinine level at baseline (0.60±0.08 vs. 0.61±0.12), 48
hours (0.60±0.09 vs. 0.61±0.10), and seven days (0.66±0.16 vs. 0.66±0.13) were lower
for the intervention group than the control group, but this difference was not statistically
significant (P > 0.05). In contrast, the GFR at baseline (92.96±17.87 vs. 91.53±13.46), 48-
hour (92.82±18.27 vs. 85.35±15.25), and seven days (90.86±17.84 vs. 85.05±14.41) were
higher in the intervention group than in the control group. However, this was not significant.
Finally, only one patient in the control group developed AKI, while no cases of AKI were
observed in the intervention group.
Conclusion: Vitamin E’s impact on AKI reduction in patients with leukemia was not
statistically significant. However, it positively affected creatinine and GFR levels in the
intervention group. In addition, no AKI cases were observed in the intervention group.
- Vitamin E
- Acute kidney injury
- Leukemia
- Chemotherapy
- Vincristine
How to Cite
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