Investigating Renal Dysfunction and Dyslipidemia in Obese and Overweight Children Renal Dysfunction and Dyslipidemia in Obese and Overweight Children
Journal of Pediatric Nephrology,
Vol. 11 No. 3 (2023),
16 October 2024
https://doi.org/10.22037/jpn.v11i3.45591
Abstract
Background and Aim: Childhood obesity and chronic kidney disease (CKD) are both substantial
public health concerns. Obesity is known to contribute directly and indirectly to the development
of CKD. This study evaluates kidney damage related to obesity and metabolic comorbidities in
overweight and obese children.
Methods: A prospective cross-sectional study was conducted in the Obesity Clinic of a
Children’s Hospital in Iran from 2017 to 2020 on obese and overweight children aged 2 to 18
years. Biochemical parameters, such as total cholesterol, high-density lipoprotein (HDL), lowdensity
lipoprotein (LDL), triglyceride (TG), creatinine, estimated glomerular filtration rate and
fasting glucose were measured. A binary logistic regression was used to assess the association
between body mass index (BMI) Z-score and biochemical parameters. Two-sided P<0.05 was
considered significant.
Results: The participants exhibited a mean BMI Z-score of 2.39±0.70. The prevalence of obesity
was 78.6% among boys and 52.9% among girls. Additionally, 78.9% of them had an estimated
glomerular filtration rate of less than 90 mL/min/1.73 m2. Impaired fasting glucose was present in
15.6% of the participants, while hypercholesterolemia was noted in 66.7% of them.
Conclusion: Significant percentages of overweight and obese children have decreased estimated
glomerular filtration rate. In addition, dyslipidemia, in the forms of high cholesterol, high TG,
and low HDL is found in these children.
- Obesity
- Dyslipidemia
- Chronic Kidney Disease
- Glomerular filtration rate
- Chronic kidney disease (CKD)
- Child
How to Cite
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