Co-occurrence of Immunoglobin A Vaculitis and Immunoglobulin A Nephropathy Suggesting Common Pathogenesis: A Case Report Co-occurrence of Henoch–Schönlein Purpura and Ig A Nephropathy
Journal of Pediatric Nephrology,
Vol. 11 No. 3 (2023),
16 October 2024
https://doi.org/10.22037/jpn.v11i3.45211
Abstract
Immunoglobulin A (IgA) vasculitis, also known as Henoch-Schönlein purpura, and
IgA nephropathy are two different diseases of the same clinical spectrum. They may
occur sequentially in the same patient and exhibit overlapping clinical presentations,
immunological characteristics, and pathological features. The clinical presentation and the
degree of severity are different for individual cases. In this study, we report a girl who initially
presented with Henoch-Schönlein purpura, and on follow-up, renal biopsy was suggestive of
IgA nephropathy. Accordingly, this presentation suggests the common pathogenesis of both
diseases and the need for long-term follow-up of patients with Henoch-Schönlein purpura.
- Henoch–Schönlein purpura (HSP)
- HSP nephritis
- Immunoglobulin A nephropathy (IgAN)
- IgA vasculitis
How to Cite
References
Sestan M, Jelusic M. Diagnostic and management strategies
of iga vasculitis nephritis/henoch-schönlein purpura
nephritis in pediatric patients: Current perspectives. Pediatric
Health Med Ther. 2023; 14:89-98. [DOI:10.2147/PHMT.
S379862] [PMID]
Leung AKC, Barankin B, Leong KF. Henoch-Schönlein
Purpura in Children: An updated review. Curr Pediatr Rev.
; 16(4):265-76. [DOI:10.2174/1573396316666200508104708
] [PMID]
Gadola SD. [IgA vasculitis - similarities and differences to
IgA nephropathy (German)]. Ther Umsch. 2022; 79(5):260-8.
[DOI:10.1024/0040-5930/a001359] [PMID]
Thorner PS, Farine M, Arbus GS, Poucell S, Baumal R. IgA
nephropathy: Henoch-Schönlein purpura and Berger's disease
in one patient. Int J Pediatr Nephrol. 1986; 7(3):131-6.
[PMID]
Hughes FJ, Wolfish NM, McLaine PN. Henoch-Schönlein
syndrome and IgA nephropathy: A case report suggesting
a common pathogenesis. Pediatr Nephrol. 1988; 2(4):389-92.
[DOI:10.1007/BF00853426] [PMID]
Ravelli A, Carnevale-Maffè G, Ruperto N, Ascari E, Martini
A. IgA nephropathy and henoch-schönlein syndrome
occurring in the same patient. Nephron. 1996; 72(1):111–2.
[DOI:10.1159/000188822]
Chishiki M, Kawasaki Y, Kaneko M, Ushijima Y, Ohara S,
Abe Y, et al. A 10-year-old girl with IgA nephropathy who 5
years later developed the characteristic features of Henoch-
Schönlein purpura nephritis. Fukushima J Med Sci. 2010;
(2):157-61. [PMID]
Yamabe H, Kaizuka M, Tsunoda S, Nagasawa T, Nomura
K, Shimada M. Henoch-Schönlein nephritis manifesting with
purpura 15 years after diagnosis of IgA nephropathy. Case
Rep Nephrol. 2019; 2019:1042648. [PMID]
Weerasooriya WL, Ratnatunga NV, Rangana D, Thalgahagoda
S. Delayed presentation with Henoch-Schölen purpura
in a patient with immunoglobulin A nephropathy.
Asian J Pediatr Nephrol. 2021; 4(1):33-5. [DOI:10.4103/ajpn.
ajpn_36_20]
Su Q, Liang Y, Wang N, Dou Z, Rong Z, Zhao X, et al.
“Clinicopathologic comparisons of IgA nephropathy and IgA
vasculitis nephropathy in children: A ten-year single-centre
experience.” Turk J Med Sci. 2021; 51(5):2683-9. [DOI:10.3906/
sag-2104-319] [PMID]
Zhong X, Ding J. Diagnosis and treatment of IgA nephropathy
and IgA vasculitis nephritis in Chinese children. Pediatr
Nephrol. 2023; 38(6):1707-15. [DOI:10.1007/s00467-022-
-6] [PMID]
Assadi F. Childhood Henoch-Schonlein nephritis: A multivariate
analysis of clinical features and renal morphology at
disease onset. Iran J Kidney Dis. 2009; 3(1):17-21. [PMID]
Davin JC, Ten Berge IJ, Weening JJ. What is the difference
between IgA nephropathy and Henoch-Schönlein purpura
nephritis? Kidney Int. 2001; 59(3):823-34. [DOI:10.1046/j.1523-
2001.059003823.x] [PMID]
Waldo FB. Is Henoch-Schönlein purpura the systemic form
of IgA nephropathy? Am J Kidney Dis. 1988; 12(5):373-7.
[DOI:10.1016/S0272-6386(88)80028-3] [PMID]
- Abstract Viewed: 224 times
- pdf Downloaded: 119 times