Humoral Immunity Status in Pediatric Patients with Familial Mediterranean Fever: Exploring the Role of IgA Familial Mediterranean Fever: What about IgA
Journal of Pediatric Nephrology,
Vol. 11 No. 2 (2023),
7 February 2024
https://doi.org/10.22037/jpn.v11i3.43855
Abstract
Background and Aim:Research on the role of the adaptive immune system in familial Mediterranean fever (FMF) is limited. The aim of this study was to investigate the levels of immunoglobulins (Ig) IgG, IgM, IgA and absolute lymphocyte count (ALC) in FMF patients compared to normal subjects.
Methods: Patients diagnosed with FMF were included in the study. At the time of data entry, we recorded demographic information, mutation type, ALC, eosinophils and levels of IgA, IgG, IgM and IgE. We compared these variables with those of the control group.
Results: Thirty-five FMF patients (M/F=9/26) were included in this study. There was no significant difference between the mean quantitative levels of the immunoglobulins (IgA, IgG and IgM) and Ig E between the patient and control groups (P>0.05). Compared with the biallelic and monoallelic mutations, we found higher Ig A levels in the biallelic group (1.5±0.7 vs 0.9±0.3 mg/dL, respectively P=0.008). An interesting finding was that three patients with homozygous M694 mutation had an Ig A level above the upper limit while.
Conclusion: No significant difference was found in terms of humoral immunity between FMF patients and healthy individuals. However, we believe that IgA levels should be examined in patients with severe FMF manifestations; the finding of high IgA levels in three patients with a homozygous M694V mutation supports our hypothesis.
- Familial Mediterranean fever
- Adaptive immunity
- Immunoglobulin A (IgA)
How to Cite
References
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