Hemorrhagic Cystitis Following Cephalexin Overdose in a Child.
Journal of Pediatric Nephrology,
Vol. 1 No. 1 (2013),
24 July 2013
,
Page 37-38
https://doi.org/10.22037/jpn.v1i1.4342
Abstract
How to Cite This Article: Pournasiri Z, Farnaghi F, Mehregan F, Tehranchi ST. Hemorrhagic Cystitis Following Cephalexin Overdose
in a Child. J Ped. Nephrology 2013 July;1(1):37-38
Hemorrhagic Cystitis (HC) is an infectious or noninfectious process that leads to gross hematuria originating from the urinary bladder mucosa. A previously healthy 2.5-year-old boy was referred to our center five hours after ingestion of 120 ml (6 g) of cephalexin suspension with abdominal pain, diarrhea, vomiting, and gross hematuria. The results of the general physical examination were unremarkable except for mild suprapubic tenderness. He was admitted to the hospital and hydrated.
Laboratory tests on admission showed normal CBC & electrolytes, normal PT&PTT, negative coombs test, many RBCs per high-power field (HPF) in the urine, and normal urinary tract sonography. Within 24 hours, the urine cleared, showing only 1 to 2 red blood cells per high power field with no changes in the CBC, electrolytes, or kidney function tests. His urine culture was negative. Although there are reports of antibiotic- induced HC, the rarity of cephalosporins and cephalexin induced hemorrhagic cystitis encouraged us to report this observation.
Keywords: Cystitis; Hematuria; Cephalexin; Poisoning; Child.
How to Cite
References
Ratliff TR, Williams RD. Hemorrhagic cystitis, chemotherapy, and bladder toxicity. J Urology 1998;159(3):1044.
Levenback C, Eifel PJ, Burke TW, Morris M, Gershenson DM. Hemorrhagic cystitis following radiotherapy for stage Ib cancer of the cervix. Gynecol Oncol. 1994;55(2):206-10.
Arad E, Naschitz J, Yeshurun D. Hemorrhagic cystitis as a presenting symptom of acute infection with Salmonella typhi. Harefuah. 1996;130(12):815-6.
Kok LP. Boon's disease: hemorrhagic cystitis in conjunction with massive exfoliation of degenerated urothelial cells (apoptosis?) during intercontinental flights in an otherwise healthy person. Diagn Cytopathol 2001 ;25(6):361-4.
Meyers KE, Pfieffer S, Lu T, Kaplan BS .Genitourinary complications of SLE. Pediatric nephrology 2000;14(5):416-421.
Chattopadhyay S, Mukherjee DK. A case of drug induced haemorrhagic Cystitis. Indian j of pharmacology 2003;35(1):63-64.
Hassan Z. Management of refractory hemorrhagic cystitis following hematopoietic stem cell transplantation in children. Pediatr Transplant 2011; 15(4):348-61.
Bright DA, Gaupp FB, Becker LJ, Schiffert MG, Ryken TC. Amoxicillin overdose with gross hematuria. West J Med 1989;150(6):698-9.
Catania MA, Oteri A, Caiello P, et al. Hemorrhagic cystitis induced by an herbal mixture. South Med J 2010;103(1):90-2.
Toma Y, Ishiki T, Nagahama K, et al. Penicillin G-induced hemorrhagic cystitis with hydronephrosis. Intern Med 2009;48(18):1667-9.
Hudson RG, Cain MP. Risperidone associated hemorrhagic cystitis. J Urology 1998 ;160(1):159.
Relling MV, Schunk JE. Drug-induced hemorrhagic cystitis. Clin Pharm 1986;5(7):590-7.
Fushteĭ IM, Torbin ES, Polivoda SN. Drug-induced nephropathy and hemorrhagic cystitis as an adverse reaction to kanamycin. Klin Med (Mosk) 1989;67(8):105.
- Abstract Viewed: 726 times
- PDF Downloaded: 240 times