Heavy Metal Exposure in Alport Syndrome in an Adolescent: A Case Report Heavy Metal Exposure in Alport Syndrome
Journal of Pediatric Nephrology,
Vol. 11 No. 2 (2023),
7 February 2024
https://doi.org/10.22037/jpn.v12i2.42208
Abstract
Alport syndrome is an inherited glomerular disease characterized by hematuria, proteinuria,
hypertension, progressive kidney failure, hearing loss, and ocular pathologies. It is caused
by a mutation in COL4A3, COL4A4, or COL4A5 genes. A lamellar or uniformly thinned
glomerular basement membrane is a pathognomonic histologic appearance for Alport
syndrome. Light microscopy shows nonspecific findings, including mesangial matrix
expansion and hypercellularity. Renal tubules are other main components of the kidney and the
major sites in response to injuries. They are vulnerable to various conditions, such as hypoxia,
proteinuria, and nephrotoxic substances, including heavy metals, like lead and mercury.
We demonstrated that a patient with asymptomatic Alport syndrome may have accelerated
worsening of kidney functions due to occupational exposure to lead and mercury. Regarding
the initial diagnosis with current clinical and laboratory findings in patients, it is noteworthy
that there is always the possibility of another pathology, and additional investigations may
be needed. Besides, when considering public health issues and the financial burden due to
occupational diseases, we desired to draw attention to the importance and need to create safer
work environments and make frequent inspections.
- Mercury
- Lead
- Alport syndrome
- Kidney
- Public health
How to Cite
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