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  3. Vol. 10 No. 4 (2022): Autumn 2022
  4. Reviews

Vol. 10 No. 4 (2022)

Esfand 2023

Etiology of Hematuria in Children: A Review Article Etiology of Hematuria in Children

  • Mohsen Akhavan Sepahi
  • Mohammad Hoseinn Akhavan Sepahi

Journal of Pediatric Nephrology, Vol. 10 No. 4 (2022), 15 Esfand 2023
https://doi.org/10.22037/jpn.v10i4.40069 Published: 2023-01-30

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Abstract

 

Please Click Here and Go to Continuing Medical Education (CME)

Background and Aim: The etiology of hematuria in children is different. Hematuria is
a known risk factor for developing chronic kidney disease (CKD). This narrative review
aimed to evaluate the etiology of hematuria in children, mainly new hematuria research, to
provide an update on the management, and complications that can improve the prognosis of
hematuria.

Methods: For this narrative review, articles from several sources, including Scopus, Google
Scholar, Embase, Web of Science, PubMed, and the Directory of Open Access Journals were used.
Results: Kidney and urinary tract infection (UTI) is the most common cause of hematuria
in children. Renal structural abnormalities, hypercalciuria, urinary stones, and extrarenal
abnormalities associated with hematuria.

Conclusion: Hematuria is a symptom and very dangerous, but due to various causes in these
patients, it is needed in all patients.

The challenge for pediatric nephrologists is the early diagnosis of children with progressive
forms of kidney disease from other causes. This manuscript reviews the multiple potential
causes of microscopic hematuria and provides a framework for the initial assessment and
monitoring of such patients. No internationally accepted, uniform, evidence-based algorithm
exists for its diagnostic evaluation anywhere. It is recommended that extensive public
attention be paid to the etiology and management of hematuria.

 

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Keywords:
  • Hematuria
  • Urinary tract infection
  • Chronic kidney disease
iranspn.ircme.ir
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How to Cite

1.
Akhavan Sepahi M, Akhavan Sepahi MH. Etiology of Hematuria in Children: A Review Article : Etiology of Hematuria in Children. J Ped Nephrol [Internet]. 2023 Jan. 30 [cited 2026 Jul. 8];10(4). Available from: https://journals.sbmu.ac.ir/jpn/article/view/40069
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References

Yap H, Shenoy M. Approach to the child with hematuria

and/or proteinuria. In: Francesco E, Stuart LG, Arvind B,

Bates CA, Shroff R, editors. Pediatric nephrology. Cham:

Springer; 2022. [Link]

Flores FX. Clinical evaluation of the child with hematuria.

In: Kleigman RM, Behrman RE, Stanton BF Geme St, Schor

NF, editors. Nelson essentials of pediatrics. Amsterdam: Elsevier

Health Sciences; 2018. [Link]

Brown DD, Reidy KJ. Approach to the child with hematuria.

Pediatr Clin North Am. 2019; 66(1):15-30. [DOI:10.1016/j.

pcl.2018.08.003] [PMID]

Kallash M, Rheault MN. Approach to persistent microscopic

hematuria in children. Kidney360. 2020; 1(9):1014-20.

[DOI:10.34067/KID.0003222020] [PMID] [PMCID]

Viteri B, Reid-Adam J. Hematuria and proteinuria in children.

Pediatr Rev. 2018; 39(12):573-87. [DOI:10.1542/pir.2017-

[PMID] [PMCID]

Bolenz C, Schröppel B, Eisenhardt A, Schmitz-Dräger BJ,

Grimm MO. The investigation of hematuria. Dtsch Arztebl

Int. 2018; 115:801-7. [DOI:10.3238/arztebl.2018.0801] [PMID]

[PMCID]

Bignall ONR, Dixon BP. Management of hematuria in

children. Curr Treat Options Pediatr. 2018; 4(3):333-49.

[DOI:10.1007/s40746-018-0134-z] [PMID] [PMCID]

Chan MM, Gale DP. Isolated microscopic haematuria of

glomerular origin: Clinical significance and diagnosis in the

st century. Clin Med. 2015; 15(6):576-80. [DOI:10.7861/clinmedicine.

-6-576] [PMID] [PMCID]

Horváth O, Szabó AJ, Reusz GS. How to define and assess

the clinically significant causes of hematuria in childhood.

Pediatr Nephrol. 2022; 1-16. [DOI:10.1007/s00467-022-05746-

[PMCID]

Yuste C, Gutierrez E, Sevillano AM, Rubio-Navarro A,

Amaro-Villalobos JM, Ortiz A, et al. Pathogenesis of glomerular

haematuria. World J Nephrol. 2015; 4(2):185-95. [PMCID]

[PMID]

Yuste C, Rivera F, Moreno JA, López-Gómez JM. Haematuria

on the Spanish registry of glomerulonephritis. Sci Rep.

; 6:19732. [DOI:10.1038/srep19732] [PMID] [PMCID]

Dong ZY, Wang YD, Qiu Q, Hou K, Zhang L, Wu J, et

al. Dysmorphic erythrocytes are superior to hematuria for

indicating non-diabetic renal disease in type 2 diabetics. J

Diabetes Investig. 2016; 7(1):115-20. [DOI:10.1111/jdi.12371]

[PMID] [PMCID]

Moreno JA, Sevillano Á, Gutiérrez E, Guerrero-Hue M,

Vázquez-Carballo C, Yuste C, et al. Glomerular hematuria:

Cause or consequence of renal inflammation? Int J Mol Sci.

; 20(9):2205. [DOI:10.3390/ijms20092205] [PMID] [PMCID]

Sevillano AM, Gutiérrez E, Yuste C, Cavero T, Mérida E,

Rodríguez P, et al. Remission of hematuria improves renal survival

in IgA nephropathy. J Am Soc Nephrol. 2017; 28(10):3089-

[DOI:10.1681/ASN.2017010108] [PMID] [PMCID]

Hou-Hsien Lin H, Yen CY, Lim LM, Hwang DY, Tsai JC,

Hwang SJ, et al. Microscopic haematuria and clinical outcomes

in patients with stage 3-5 nondiabetic chronic kidney

disease. Sci Rep. 2015; 5:15242. [DOI:10.1038/srep15242]

[PMID] [PMCID]

Akhavan Sepahi MS, Shajari A, Shakiba M, Khalife

Shooshtary F. Acute glomerulonephritis: A 7 years follow

up of children in center of Iran. Acta Medica Iranica. 2011;

(6):375-8. [Link]

Akhavan Sepahi M, Eftekhari SS, Rashidinia S, Shahmoradi

S, Shokrollahi SM, Pormehr S. Relationship between

urinary reflux and nephrolithiasis in children-a cross-sectional

study. Int J Pediatr. 2017; 5(5):4965-73. [DOI:10.22038/

ijp.2017.22728.1898]

Razavi MR, Vahedian M, Motharinejad F, Jafari H, Akhavan

Sepahi MA. Effect of polycitra-K and bicitra in the treatment

of pediatric nephrolithiasis: A double-blind randomized trial.

Med J Islam Repub Iran. 2022; 36. [DOI:10.47176/mjiri.36.70]

[PMID]

Esteghamati M, Sorkhi H, Mohammadjafari H, Derakhshan

A, Sadeghi-Bojd S, Momtaz HE, et al. Prevalence of

reflux nephropathy in Iranian children with solitary kidney:

Results of a multi-center study. BMC Nephrol. 2022; 23(1):1-6.

[DOI:10.1186/s12882-022-02703-z] [PMID] [PMCID]

Amouzadeh MH, Sepahi MA, Abasi E. Proteinuria in two

sisters with Beaulieu-Boycott-Innes syndrome, a case report.

Iran J Kidney Dis. 2020; 14(4):312-4. [PMID]

Akhavansepahi M, Tabarai Y. Screening of hypercalciuria

among children with persistent asymptomatic hematuria. J

Epidemiol Biostat. 2017; 3(3/4):106-10. [Link]

Lopez-Giacoman S, Madero M. Biomarkers in chronic kidney

disease, from kidney function to kidney damage. World J

Nephrol. 2015; 4(1):57-73. [DOI:10.5527/wjn.v4.i1.57] [PMID]

[PMCID]

Mehta RL. Renal recovery after acute kidney injury and

long-term outcomes: is time of the essence? JAMA Netw

Open. 2020; 3(4):e202676. [DOI:10.1001/jamanetworkopen.

2676] [PMID] [PMCID]

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