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  3. Vol. 10 No. 3 (2022): Summer 2022
  4. Reviews

Vol. 10 No. 3 (2022)

December 2022

Eculizumab in Pediatric Kidney Disorders: A Review Eculizumab in Kidney Disorders

  • Mahnaz Jamee
  • Yeganeh Farsi
  • Amir Hossein Akhondi
  • Farnaz Kamali
  • Amir Hossein Hajialigol
  • Mahbubeh Mirzaee
  • Masoumeh Mohkam

Journal of Pediatric Nephrology, Vol. 10 No. 3 (2022), 12 December 2022 , Page 103-111
https://doi.org/10.22037/jpn.v10i3.38928 Published: 2022-09-28

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Abstract

Eculizumab is a humanized monoclonal antibody targeting the C5 (complement 5) member
of complement proteins and inhibiting its cleavage to C5a and C5b. Eculizumab has been
proven to be effective in a wide array of nephrologic, neurologic, and hematologic pediatric
disorders. Kidney disorders, particularly those with immune-mediated pathomechanism,
are the most common indications of eculizumab, including atypical hemolytic uremic
syndrome (aHUS), hemolytic uremic syndrome (HUS), membranoproliferative
glomerulonephritis (MPGN), immunoglobulin A (IgA) nephropathy, hematopoietic stem
cell transplant-associated thrombotic microangiopathy, and less commonly post-infectious
glomerulonephritis and diffuse proliferative lupus nephritis. In this review, we aimed to
summarize the current evidence on approved and off-label applications of eculizumab and
their specific considerations in pediatric kidney disorders.

Keywords:
  • Eculizumab
  • Complement C5,
  • Complement
  • Kidney
  • Chil
  • pdf

How to Cite

1.
Jamee M, Farsi Y, Akhondi AH, Kamali F, Hajialigol AH, Mirzaee M, et al. Eculizumab in Pediatric Kidney Disorders: A Review: Eculizumab in Kidney Disorders. J Ped Nephrol [Internet]. 2022 Sep. 28 [cited 2026 Jul. 8];10(3):103-11. Available from: https://journals.sbmu.ac.ir/jpn/article/view/38928
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Online ISSN (e-ISSN): 2345-3176                                                                  

The "Journal of Pediatric Nephrology" is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. 

 

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