Evaluation of the Clinical Findings of Pediatric Patients With Vesicoureteral Reflux to Assess Disease Severity Vesicoureteral Reflux and Disease Severity
Journal of Pediatric Nephrology,
Vol. 10 No. 3 (2022),
12 December 2022
,
Page 112-116
https://doi.org/10.22037/jpn.v10i3.38802
Abstract
Background and Aim: This study aims to investigate how to benefit from clinical and
laboratory methods for further selection in the decision-making process to perform a
cystogram and assess the severity of vesicoureteral reflux (VUR).
Methods: We retrospectively reviewed the voiding cystourethrography (VCUG), ultrasound
(US), and medical records of pediatric patients with VUR. The exclusion criteria included
having neurological lesions, a posterior urethral valve, and a lack of documentation of a renal
ultrasound or voiding cystourethrography (VCUG). At the time of data entry, we retrieved
demographic findings and laboratory test results, including routine biochemical parameters,
complete blood count, and calculated blood sodium/potassium ratio
Results: Sixty-three pediatric patients with VUR were enrolled in this study. The mean (SD)
age of the patients (female/male=37/26) at the time of diagnosis was 62.0±6.5 months (range
1-195 months). Seventeen patients (26.9%) had high-grade VUR, and 46 patients (73.1%)
had low-to-moderate-grade VUR. The mean potassium level of the mean serum sodium to
potassium (Na/K) ratio was significantly lower in the high-grade VUR group (4.7±0.5 vs.
4.3±0.4 mEq/L, P=0.022, 29±3 vs. 32±3, P=0.029, respectively). The proportion of patients
with severe anterior-posterior (AP) diameter dilation was significantly higher in the lowgrade
VUR group than in the high-grade VUR group (4 [23.5%] vs. 35 [76.5%], P=0.005).
Conclusion: We conclude that the low serum sodium to potassium (Na/K) ratio allows us to
predict the VUR grade. The effect of VUR on the renin-angiotensin-aldosterone system can
be demonstrated by prospective controlled studies.
- Child
- Kidney
- Vesicoureteral reflux (VUR)
- Potassium
How to Cite
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