Streptococcus Pneumonia-Associated Hemolytic Uremic Syndrome: A Case Report
Journal of Pediatric Nephrology,
Vol. 1 No. 2 (2013),
Hemolytic uremic syndrome (HUS), a disease that destroys red blood cells, is the most common cause of sudden, short term acute kidney failure in children. By far, the commonest subgroup (>90% of childhood HUS) is induced by shiga toxin producing bacteria, usually enterohemorrhagic Escherichia coli (EHEC). These patients typically have a prodrome of diarrhea. Another important subgroup that is readily identified on clinical grounds follows invasive Streptococcus pneumonia infection. These infants tend to be younger than those with D + HUS, and the syndrome is very rare after the age of 4 years. They present with pneumonia, empyema, meningitis, and less often, isolated septicemia. Another group of patients may have mutations in complement regulators, and less often, inherited deficiency of von Willebrand protease or an inborn error of cobalamin metabolism. We report a 6-month-old child who developed hemolytic uremic syndrome following S. pneumonia meningitis.
Keywords: Hemolytic-Uremic Syndrome; Meningitis; Streptococcus pneumonia; Child
- Hemolytic uremic syndrome
- streptococcus pneumonia
How to Cite
Van why SK, Avner ED. Hemolytic uremic syndrome. in: Nelson Textbook of pediatrics. 2011, 19th ed. International ed. Elsevier Saunders. Philadelphia. P. 1791-1794.
Habib R, Mathieu H, Royer P. Maladie thrombothique auteriolocapillaire du rein chez l'enfant. Rev Fr Et Clin Biol 1958;3: 891-895.
Nathanson S, Deschenes G. prognosis of streptococcus pneumonia induced hemolytic uremic syndrome. Pediatr Nephrol 2001;16:362-365.
banerjee R, Hersh Al, Newland J, et al. Streptococcus pneumonia_associated hemolytic uremic syndrome among children in North America. Peditr infect dis J. 2011;30(9):736-9.
Kaplan SL, Mason EO jr, Basson WJ, et al. Three year multicenter surveillance of systemic pneumococcal infections in children. Pediatrics 1998:102:538-545.
Brandt J, Wong C, Mihm S, et al. invasive pneumococcal disease and hemolytic uremic syndrome. Pediatrics. 2002; 110(2):371-376.
So CC, Leung YY, Yip SF, et al. Common association of haemolytic uraemic syndrome with invasive Streptococcus pneumonia infection in five Chinese paediatric patients. Hong Kong Med J. 2011;17(3):237-41.
Gilbert RD, ArgentAC. Streptococcus pneumoniae-associatedhemolytic uremic syndrome. Pediatr Infect Dis J 1998; 17:530–532.
Constantinescu AR, Bitzan M, Weiss LS, et al. Non-enteropathic hemolytic uremic syndrome: causes and short-term course. Am J Kidney Dis 2004;43:976..
Bender JM, Ampofo K, Byington CL, et al. Epidemiology of Streptococcus pneumoniae-induced hemolytic uremic syndrome in Utah children. Pediatr Infect Dis J 2010; 29:712.
Proulx F, Liet Jm, David M, et al. Hemolytic uremic syndrome associated with invasive streptococcus pneumonia infection. Pediatrics 2000:105:462-463.
Karimi M, Sabzi A, Peyvandi F, Mannucci PM. Clinical and laboratory patterns of the haemolytic uraemic syndrome and thrombotic thrombocytopenic purpura in southern Iran. Intern Emerg Med 2006;1(1):35-39.
Shurin SB, Anderson P, Zollinger J, Rathbun RK. Pathophysiology of hemolysis in infections with Hemophilus influenzae type b. J Clin Invest. 1986;77(4):1340-1348.
Ramakrishnan M, Moïsi JC, Klugman KP, et al. Increased risk of invasive bacterial infections in African people with sickle-cell disease: a systematic review and meta-analysis. Lancet Infect Dis. 2010;10(5):329-37.
Kapur G, Valentini RP, Mattoo Tk, Warrier I, Imam AA. Cefteriaxon induced hemolysis complicated by acute renal failure. Pediatric blood cancer 2001;10:139-142.
Asadi karam MR, Bouzari S, Oloomi M, Aslani MM, Jafari A. Phenotypic and genotypic characterization of enteropathogenic E_coli ( EPEC) strains in Tehran, Iran. Iran J Microbiol. 2010; 2(1):3-7.
Ellis D. Avner. William E. Harmon, Pediatric Nephrology. 6th ed. Springer. 2009.P. 1155-1177.
- Abstract Viewed: 337 times
- PDF Downloaded: 100 times