Anaplastic Wilms’ Tumor Mimicking a Rhabdoid Tumor: A Diagnostic Challenge Wilms’ Tumor Mimicking a Rhabdoid Tumor
Journal of Pediatric Nephrology,
Vol. 9 No. 3 (2021),
4 September 2021
https://doi.org/10.22037/jpn.v9i3.35043
Abstract
Rhabdoid tumor of the kidney (RTK) mimics other renal tumors histologically, but a rhabdoid tumor mimicking an anaplastic Wilms’ tumor has been rarely reported. Wilms’ tumor classically comprises three histological components, including a blastema, epithel ium, and stroma. The degree of maturation of these components makes the histological appearance of this tumor unique. Anaplasia is defined by the presence of extreme nuclear and mitotic atypia. Most of these lesions can be differentiated on the basis of light microscopic histological investigations. Herein we report a case of pediatric anaplastic Wilms’ tumor that was difficult to differentiate from a mesenchymal lesion histologically. The application of immunohistochemistry and extensive sampling of the lesion was critical for accurate diagnosis. Keywords: Wilm’s Tumor; Child; Rhabdoid Tumor.- Wilm’s Tumor
- Child
- Rhabdoid Tumor
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References
Annual incidence of rhabdoid tumors among children <15, 2000-2008. Surveillance, Epidemiology, and End Results (SEER) Program; Bethesda, MD: 2011. Volume SEER 17. SEER*Stat version 7.0.6. [Google Scholar]
Haas JE, Palmer NF, Weinberg AG, Beckwith JB. Ultrastructure of malignant rhabdoid tumor of the kidney. A distinctive renal tumor of children. Hum Pathol 1981;Jul. 12(7):646-57.
Howlader N, Noone AM, Krapcho M, et al. SEER Cancer Statistics Review (CSR) 1975-2016. Bethesda, Md: 2019: National Cancer Institute. Available online. Last accessed February 4, 2021.
Popov SD, Sebire NJ, Pritchard-Jones K, et al. Renal tumors in children aged 10-16 Years: a report from the United Kingdom Children's Cancer and Leukaemia Group. Pediatr Dev Pathol 2011;14(3):189-93.
Indolfi P, Jenkner A, Terenziani M, et al. Synchronous bilateral Wilms tumor: a report from the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP). Cancer 2013; 119 (8): 1586-92.
Hamilton TE, Ritchey ML, Haase GM, et al. The management of synchronous bilateral Wilms tumor: a report from the National Wilms Tumor Study Group. Ann Surg 2011; 253 (5): 1004-10.
Dome JS, Perlman EJ, & Graf N. Risk stratification for Wilms tumor: current approach and future directions. Am. Soc. Clin. Oncol. Educ. Book 2014; 34: 215–223.
Vujanic GM, et al. Revised International Society of Paediatric Oncology (SIOP) working classification of renal tumors of childhood. Med. Pediatr. Oncol. 2002;38:79–82.
Beckwith JB, & Palmer NF. Histopathology and prognosis of Wilms tumors: results from the first national Wilms’ tumor study. Cancer 1978;41:1937–1948.
Faria P, et al. Focal versus diffuse anaplasia in Wilms tumor - new definitions with prognostic significance: a report from the National Wilms Tumor Study Group. Am. J. Surg. Pathol. 1996; 20: 909–920.
Vujanić GM, Gessler M, Ooms AHAG, et al. The UMBRELLA SIOP–RTSG 2016 Wilms tumour pathology and molecular biology protocol. Nat Rev Urol 2018; 15: 693–701. https://doi.org/10.1038/s41585-018-0100-3
Vujanic GM, Sandstedt B, Kelsey A, & Sebire NJ. Central pathology review in multicenter trials and studies: lessons from the nephroblastoma trials. Cancer 2009; 115: 1977–1983.
Al-Salem AH. Renal Tumors: Wilms Tumor (Nephroblastoma). An Illustrated Guide to Pediatric Surgery 2014; 479–490. doi:10.1007/978-3-319-06665-3_62
Weeks D A, Beckwith JB, Mierau GW, & Zuppan CW. Renal Neoplasms Mimicking Rhabdoid Tumor of Kidney. The American Journal of Surgical Pathology 1991; 15(11): 1042–1054. doi:10.1097/00000478-199111000-00003
D'Hooghe E, Vujanic GM. Nephroblastoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/kidneytumorwilmkids.html.
Edward P Tagge, Patrick B Thomas, H Biemann Othersen. Wilms' Tumor. Pediatric Surgery (Sixth Edition):2006;445-466
Hoot AC, Russo P, Judkins AR, Perlman EJ, Biegel JA. Immunohistochemical analysis of hSNF5/INI1 distinguishes renal and extra-renal malignant rhabdoid tumors from other pediatric soft tissue tumors. Am J Surg Pathol. 2004; Nov28(11):1485-91. doi: 10.1097/01.pas.0000141390.14548.34.
Geller J I. Current standards of care and future directions for “high-risk” pediatric renal tumors: Anaplastic Wilms tumor and Rhabdoid tumor. Urologic Oncology: Seminars and Original Investigations 2015; 34(1): 50–56. doi:10.1016/j.urolonc.10.012.
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