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  3. Vol. 9 No. 4 (2021): Autumn
  4. Case Reports

Vol. 9 No. 4 (2021)

November 2021

Bilateral Nephromegaly in a Child with Severe Iron-Deficiency Anemia

  • Danna Weizmann
  • Dominique S Genest
  • Catherine Litalien
  • Geneviève Benoit

Journal of Pediatric Nephrology, Vol. 9 No. 4 (2021), 10 November 2021 , Page 1-3
https://doi.org/10.22037/jpn.vi.34772 Published: 2021-11-08

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Abstract

Nephromegaly in childhood can result from a wide variety of causes, yet iron-deficiency anemia has not been previously described. We report a child with severe iron-deficiency anemia associated with transient bilateral nephromegaly. We hypothesize that increased renal production of erythropoietin as well as greater cardiac output with subsequent glomerular hyperfiltration secondary to critical anemia explained the observed nephromegaly. The normalization of kidney size following resolution of anemia supports this hypothesis. Our case report suggests an additional etiology of bilateral nephromegaly in the pediatric population and thus merits attention among physicians.

Keywords:
  • anemia; erythropoietin; hypoxia; nephromegaly
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How to Cite

1.
Weizmann D, Genest DS, Litalien C, Benoit G. Bilateral Nephromegaly in a Child with Severe Iron-Deficiency Anemia. J Ped Nephrol [Internet]. 2021 Nov. 8 [cited 2026 Jul. 8];9(4):1-3. Available from: https://journals.sbmu.ac.ir/jpn/article/view/34772
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References

1. Zelikovic, I. and I. Eisenstein, Practical algorithms in pediatric nephrology. 2008: Karger Medical and Scientific Publishers.
2. Organization, W.H., Worldwide prevalence of anaemia 1993-2005: WHO global database on anaemia. 2008.
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8. Hirschberg, R., Glomerular hyperfiltration in sickle cell disease. 2010, Am Soc Nephrol.
9. Olaniran, K.O., et al., Sickle cell nephropathy in the pediatric population. Blood purification, 2019. 47(1-3): p. 205-213.
10. Nath, K.A. and R.P. Hebbel, Sickle cell disease: renal manifestations and mechanisms. Nature Reviews Nephrology, 2015. 11(3): p. 161.
11. Alhwiesh, A., An update on sickle cell nephropathy. Saudi Journal of Kidney Diseases and Transplantation, 2014. 25(2): p. 249.
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Online ISSN (e-ISSN): 2345-3176                                                                  

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