Urinary Level of Interleukin-8 in Acute Pyelonephritis
Journal of Pediatric Nephrology,
Vol. 9 No. 2 (2021),
https://doi.org/10.22037/jpn.v8i2.33880
Abstract
Backgroundand Aim: urinary tract infection is a prevalent disease in children. Determining the location of the bacterial invasion has a great impact on the treatment, follow-up, and complications. For this purpose, different laboratory and imaging methods are used, which are often invasive or unavailable. One of the non-invasive methods is to measure biomarkers such as interlukin-8 (IL-8) in the urine.The aim of this study was to evaluate the urinary level of interleukin-8 in acutepyelonephritis.Methods: This cross- sectional study was carried out on 50 children aged 3-60 months. The children were
divided into two groups. The first group included children with acute pyelonephritis and the second group included healthy children who were randomly selected as controls. Then, the urine levels of IL-8 and creatinine were measured.
Results: The mean age of the subjects in case and control groups was 17.5 ± 22 and 22.5 ± 18.2 months, respectively (P = 0.92). The mean urinary ratio of IL- 8/Cr in the patient and control groups was 161.7 ± 90.1
and 12.2 ± 19.6 Pgr/mgr respectively, indicating a significant difference (P = 0.03). The results showed that a urinary IL-8/Cr ratio of 32 pg/mg was diagnostic according to the Receiver Operating Curve (ROC).
Conclusion: Urinary IL-8/Cr ratio can be used for early diagnosis of acute pyelonephritis
Keywords:
- Children
- Diagnosis
- Interleukin-8
- Pyelonephritis
How to Cite
1.
Eskandarifar A, Seyedzadeh S abolhassan. Urinary Level of Interleukin-8 in Acute Pyelonephritis. J Ped Nephrol [Internet]. 2021Apr.10 [cited 2022Jul.4];9(2). Available from: https://journals.sbmu.ac.ir/jpn/article/view/33880
References
References:
1. Kliegmassn RM, Stanton B, Geme JS, Schor NF, Behrman RE. Nelson textbook of
Pediatrics. 20th edition, Elsevier, 2016; 2556-2562
2. Das R, Ahmed T, Saha H, Shahrin L, Afroze F, Shahid A, et al. Clinical risk factors, bacterial aetiology, and outcome of urinary tract infection in children hospitalized with diarrhoea in Bangladesh. Epidemiology & Infection. 2017;145(5):1018-24
3. Shaikh N, Mattoo TK, Keren R, Ivanova A, Cui G, Moxey-Mims M, et al. Early antibiotic treatment for pediatric febrile urinary tract infection and renal scarring. JAMA pediatrics. 2016;170(9):848-54.
4. Marks S, Gordon I, Tullus K, Imaging in childhood urinary tract infections:
Time to reduce investigations, Pediatric Nephrol (2008) 23:9–17
5. Bitsori M, Galanakis E, Pediatric urinary tract infections: diagnosis and treatment, Expert Rev. Anti Infect. Ther. 2012, 10(10), 1153–1164
6. Hay A, Sterne J, Hood K, Little P, et al., Improving the Diagnosis and Treatment of Urinary Tract Infection in Young Children in Primary Care: Results from the DUTY Prospective Diagnostic Cohort Study Ann Fam Med 2016; 14:325-336.
7.Valdimarsson S., Jodal U., Barregård L., hansson S., Urine neutrophil gelatinase-associated lipocalin and other biomarkers in infants with urinary tract infection and in febrile controls. Pediatric Nephrol. (2017) 32:2079–2087
8.Naghshidaian R, Nasiri Kalmarzi R, Eskandarifar A, Khalafi B, Fotoohi A, Noshadi S, et al Comparing serum levels of interleukin-6 (IL-6) in acute pyelonephritis versus acute cystitis in 6 months to 12 years old children. ijca. 2017; 3 (4):13-18
9. Nanda N and Juthani M-Mehta, Novel Biomarkers for the Diagnosis of Urinary Tract Infection—A Systematic Review, Biomark Insights. 2009; 4: 111–121
10. Seyedzadeh A, Eskandarifar A, Madani SH, Amoori P, Soleimani A. Is Urinary Interleukin-8 a Marker of Vesicoureteral Reflux in Children? J Ped. Nephrology 2014 Jan; 1(3):112-115.
11. Merrikhi A.R, Keivanfar M, Gheissari A, Mousavinasab F, Urine Interlukein-8 as a Diagnostic Test for Vesicoureteral Reflux in Children, JPMA,2012, 62: S-52-54
12. Bitsori, M., Karatzi, M., Dimitriou, H. et al. Urine IL-8 concentrations in infectious and non-infectious urinary tract conditions. Pediatr Nephrol 2011-26, 2003–2007
13. Rao WH, Evans GS, Finn A, The significance of interleukin 8 in urine, Archives of Disease in Childhood, 2001;85:256-262
14.Mohkam M – Karimi A –Karimi H –Urinary interleukin 8 IN acute pyelonephritis IJKD -2008 -2:193-6
15. Shenoufy A.E issam. –Abd Elfatah M. urian level of interleukin 8 as a noninvasive marker for diagnosis of VUR, journal of medical sciences -2009- volum9 –P133-139
16.Benson M, Jodal V, Agace W, Hellstrom M, Marild S, et al., Interleukin (IL)-6 and IL-8 in Children with Febrile Urinary Tract Infection and Asymptomatic Bacteriuria, JID: 1996;174:1080-4
17. Tanınmış A, Sönmez F, Yılmaz D, Urine levels of interleukin-8 as diagnostic marker of acute pyelonephritis in children, Tepecik Eğit Hast Derg. 2016; 26(3): 221-227 | DOI: 10.5222/terh.2016.221
18.Krzemień G, Szmigielska A, Turczyn A, Pańczyk-Tomaszewska M. Urine interleukin-6, interleukin-8 and transforming growth factor β1 in infants with urinary tract infection and asymptomatic bacteriuria. Central European Journal of Immunology. 2016; 41(3):260-267.
1. Kliegmassn RM, Stanton B, Geme JS, Schor NF, Behrman RE. Nelson textbook of
Pediatrics. 20th edition, Elsevier, 2016; 2556-2562
2. Das R, Ahmed T, Saha H, Shahrin L, Afroze F, Shahid A, et al. Clinical risk factors, bacterial aetiology, and outcome of urinary tract infection in children hospitalized with diarrhoea in Bangladesh. Epidemiology & Infection. 2017;145(5):1018-24
3. Shaikh N, Mattoo TK, Keren R, Ivanova A, Cui G, Moxey-Mims M, et al. Early antibiotic treatment for pediatric febrile urinary tract infection and renal scarring. JAMA pediatrics. 2016;170(9):848-54.
4. Marks S, Gordon I, Tullus K, Imaging in childhood urinary tract infections:
Time to reduce investigations, Pediatric Nephrol (2008) 23:9–17
5. Bitsori M, Galanakis E, Pediatric urinary tract infections: diagnosis and treatment, Expert Rev. Anti Infect. Ther. 2012, 10(10), 1153–1164
6. Hay A, Sterne J, Hood K, Little P, et al., Improving the Diagnosis and Treatment of Urinary Tract Infection in Young Children in Primary Care: Results from the DUTY Prospective Diagnostic Cohort Study Ann Fam Med 2016; 14:325-336.
7.Valdimarsson S., Jodal U., Barregård L., hansson S., Urine neutrophil gelatinase-associated lipocalin and other biomarkers in infants with urinary tract infection and in febrile controls. Pediatric Nephrol. (2017) 32:2079–2087
8.Naghshidaian R, Nasiri Kalmarzi R, Eskandarifar A, Khalafi B, Fotoohi A, Noshadi S, et al Comparing serum levels of interleukin-6 (IL-6) in acute pyelonephritis versus acute cystitis in 6 months to 12 years old children. ijca. 2017; 3 (4):13-18
9. Nanda N and Juthani M-Mehta, Novel Biomarkers for the Diagnosis of Urinary Tract Infection—A Systematic Review, Biomark Insights. 2009; 4: 111–121
10. Seyedzadeh A, Eskandarifar A, Madani SH, Amoori P, Soleimani A. Is Urinary Interleukin-8 a Marker of Vesicoureteral Reflux in Children? J Ped. Nephrology 2014 Jan; 1(3):112-115.
11. Merrikhi A.R, Keivanfar M, Gheissari A, Mousavinasab F, Urine Interlukein-8 as a Diagnostic Test for Vesicoureteral Reflux in Children, JPMA,2012, 62: S-52-54
12. Bitsori, M., Karatzi, M., Dimitriou, H. et al. Urine IL-8 concentrations in infectious and non-infectious urinary tract conditions. Pediatr Nephrol 2011-26, 2003–2007
13. Rao WH, Evans GS, Finn A, The significance of interleukin 8 in urine, Archives of Disease in Childhood, 2001;85:256-262
14.Mohkam M – Karimi A –Karimi H –Urinary interleukin 8 IN acute pyelonephritis IJKD -2008 -2:193-6
15. Shenoufy A.E issam. –Abd Elfatah M. urian level of interleukin 8 as a noninvasive marker for diagnosis of VUR, journal of medical sciences -2009- volum9 –P133-139
16.Benson M, Jodal V, Agace W, Hellstrom M, Marild S, et al., Interleukin (IL)-6 and IL-8 in Children with Febrile Urinary Tract Infection and Asymptomatic Bacteriuria, JID: 1996;174:1080-4
17. Tanınmış A, Sönmez F, Yılmaz D, Urine levels of interleukin-8 as diagnostic marker of acute pyelonephritis in children, Tepecik Eğit Hast Derg. 2016; 26(3): 221-227 | DOI: 10.5222/terh.2016.221
18.Krzemień G, Szmigielska A, Turczyn A, Pańczyk-Tomaszewska M. Urine interleukin-6, interleukin-8 and transforming growth factor β1 in infants with urinary tract infection and asymptomatic bacteriuria. Central European Journal of Immunology. 2016; 41(3):260-267.
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