Henoch-Schonlein Purpura in Northeast India: Peculiarities in Presentation
Journal of Pediatric Nephrology,
Vol. 9 No. 2 (2021),
14 April 2021
https://doi.org/10.22037/jpn.v8i2.33548
Abstract
Background and Aim: Henoch-Schönlein purpura (HSP) is the most common childhood vasculitis characterized by leukocytoclastic vasculitis. This study was done to describe the presentation and immediate outcome of children admitted to HSP at our Institute. Methods: This retrospective study was conducted on children with HSP admitted to our department over a period of 7 years (January 2010 until December 2016). Results: Twenty-three children with a diagnosis of HSP were identified during the study period. The mean age was 9.4 years (4 years to 16 years). There were 15 girls and 8 boys with a male: female ratio of 1:1.9. The youngest child was 4 years old and most of the children (73.9%) were in the age group 5-12 years. Forty percent of the children presented between January and March. Major manifestations were rash (100%), joint pain (52%), renal involvement (52%), and abdominal pain (47.8%). Three (13.0%) children presented with systemic manifestations before the appearance of the rash. One child had MPGN 2 years before the onset of rash. There was no mortality. Most of the children recovered well; six (26%) had persistent hypertension and three (13%) had persistent proteinuria. Hypertensive emergency was seen in two children. One child had intussusception that resolved spontaneously. Conclusion: This study is the first study of Henoch Schonlein purpura from northeast India documenting certain peculiarities in the presentation. The results indicate a wide spectrum of presentations in HSP.
Keywords:
- Henoch Schonlein Purpura
- IGA Vasculitis
- Nephritis
How to Cite
1.
Ksoo R, Barman H, Dey B, Khonglah Y, Sangla L, Gohain Duwarah S. Henoch-Schonlein Purpura in Northeast India: Peculiarities in Presentation. J Ped Nephrol [Internet]. 2021 Mar. 31 [cited 2026 Jul. 8];9(2). Available from: https://journals.sbmu.ac.ir/jpn/article/view/33548
References
1. Sabui TK, Choudhuri J. Henoch Schonlein Purpura. In Singh S, Gupta A, Rawat A, Suri S eds. Pediatric Rheumatology. PeePee Publishers 2nd Edition Page 188-191.
2. Ardoin SP, Fels E. Henoch-scholnlein purpura. In Kleigman RM, Stanson BF, Schor NF, St Geme JW Eds. Nelson Text book of Peditrics. First south east asin edition 2016 page 1216-1218.
3. Gardner-Medwin JMM, Dolezalova P, Commins C, Southwood TR. Incidence of Henoch Schonlein purpura, Kawasaki disease and rare vasculitides in children of different ethnic origin. Lancet. 2002;360:1197-1202
4. Allen DM, Diamond LK, Howell DA. Anphylactoid purpura in children (Schonlein-Henoch syndrome): Review with follow up of renal complications. Am J Dis Child 1960; 99: 833-854.
5. Sterky G, Thilen A. A study on the onset and prognosis of acute vascular purpura in children. Acta Pediatr Scand 1960; 49: 217-229
6. Chen O, Zhu XB, Ren XP, et al. Henoch Schonlein purpura in children : Clinical analysis of 120 cases. Afr Health Sc 2013; 13: 94-99
7. Kumar L, Singh S, Goraya JS, et al. Henoch-Schonlein purpura: The Chandigarh experience. Indian pediatr. 1998; 35: 19-25
8. Bagga A, Kabra SK, Srivastava RN, Bhuyan UN. Henoch-schonlein syndrome in northern Indian children. Indian Pediatr 1991; 28: 1153-1157
9. Chen WP, Lin CY, Cheng JH, Hwang BT. Purpura nephritis in Chinese children from northern Taiwan. Child Nephrol Urol. 1988-1989;9:331-336
10. Trapani S, Micheli A, Grisolia F, et al. Henoch-Schonlein purpura in childhood: epidemiological and clinical analysis of 150 cases over a 5-year period and review of literature. Semin Arthritis Rheum. 2005; 35: 143-153
11. Calviño MC1, Llorca J, García-Porrúa C, Fernández-Iglesias JL, Rodriguez-Ledo P, González-Gay MA. Henoch-Schönlein purpura in children from northwestern Spain: a 20-year epidemiologic and clinical study. Medicine (Baltimore). 2001;80:279-290.
12. García-Porrúa C, Calviño MC, Llorca J, Couselo JM, González-Gay MA. Henoch-Schönlein purpura in children and adults: clinical differences in a defined population. Semin Arthritis Rheum. 2002;32:149-156.
13. Kawasaki Y, Ono A, Ohara S, et al. Henoch-Schonlein Purpura nephritis in childhood: Pathogenesis, prognostic factors and treatment. Fukushima J Med Sci. 2013; 59: 15-26.
14. Stewart M, Savage JM, Bell B, McCord B. Long term renal prognosis of Henoch-Schonlein purpura in unselected childhood population. Eur J Pediatr 1988; 147 : 113-115.
15. Kaku Y, Nohara K, Honda S. Renal involvement in Henoch-Schönlein purpura: A multivariate analysis of prognostic factors.Kidney Int 1998;53:1755-1759.
16. de Almeida JL, Campos LM, Paim LB, Leone C, Koch VH, Silva CA. Renal involvement in Henoch-Schönlein purpura: a multivariate analysis of initial prognostic factors. J Pediatr (Rio J). 2007;83:259-266.
17. Davin JC. Henoch-Schönlein purpura nephritis: Pathophysiology, treatment, and future strategy. Clin J Am Soc Nephrol 2011;6: 679-689.
18. Davin JC, Coppo R. Henoch-Schönlein purpura nephritis in children. Nat Rev Nephrol 2014;10:563-573.
2. Ardoin SP, Fels E. Henoch-scholnlein purpura. In Kleigman RM, Stanson BF, Schor NF, St Geme JW Eds. Nelson Text book of Peditrics. First south east asin edition 2016 page 1216-1218.
3. Gardner-Medwin JMM, Dolezalova P, Commins C, Southwood TR. Incidence of Henoch Schonlein purpura, Kawasaki disease and rare vasculitides in children of different ethnic origin. Lancet. 2002;360:1197-1202
4. Allen DM, Diamond LK, Howell DA. Anphylactoid purpura in children (Schonlein-Henoch syndrome): Review with follow up of renal complications. Am J Dis Child 1960; 99: 833-854.
5. Sterky G, Thilen A. A study on the onset and prognosis of acute vascular purpura in children. Acta Pediatr Scand 1960; 49: 217-229
6. Chen O, Zhu XB, Ren XP, et al. Henoch Schonlein purpura in children : Clinical analysis of 120 cases. Afr Health Sc 2013; 13: 94-99
7. Kumar L, Singh S, Goraya JS, et al. Henoch-Schonlein purpura: The Chandigarh experience. Indian pediatr. 1998; 35: 19-25
8. Bagga A, Kabra SK, Srivastava RN, Bhuyan UN. Henoch-schonlein syndrome in northern Indian children. Indian Pediatr 1991; 28: 1153-1157
9. Chen WP, Lin CY, Cheng JH, Hwang BT. Purpura nephritis in Chinese children from northern Taiwan. Child Nephrol Urol. 1988-1989;9:331-336
10. Trapani S, Micheli A, Grisolia F, et al. Henoch-Schonlein purpura in childhood: epidemiological and clinical analysis of 150 cases over a 5-year period and review of literature. Semin Arthritis Rheum. 2005; 35: 143-153
11. Calviño MC1, Llorca J, García-Porrúa C, Fernández-Iglesias JL, Rodriguez-Ledo P, González-Gay MA. Henoch-Schönlein purpura in children from northwestern Spain: a 20-year epidemiologic and clinical study. Medicine (Baltimore). 2001;80:279-290.
12. García-Porrúa C, Calviño MC, Llorca J, Couselo JM, González-Gay MA. Henoch-Schönlein purpura in children and adults: clinical differences in a defined population. Semin Arthritis Rheum. 2002;32:149-156.
13. Kawasaki Y, Ono A, Ohara S, et al. Henoch-Schonlein Purpura nephritis in childhood: Pathogenesis, prognostic factors and treatment. Fukushima J Med Sci. 2013; 59: 15-26.
14. Stewart M, Savage JM, Bell B, McCord B. Long term renal prognosis of Henoch-Schonlein purpura in unselected childhood population. Eur J Pediatr 1988; 147 : 113-115.
15. Kaku Y, Nohara K, Honda S. Renal involvement in Henoch-Schönlein purpura: A multivariate analysis of prognostic factors.Kidney Int 1998;53:1755-1759.
16. de Almeida JL, Campos LM, Paim LB, Leone C, Koch VH, Silva CA. Renal involvement in Henoch-Schönlein purpura: a multivariate analysis of initial prognostic factors. J Pediatr (Rio J). 2007;83:259-266.
17. Davin JC. Henoch-Schönlein purpura nephritis: Pathophysiology, treatment, and future strategy. Clin J Am Soc Nephrol 2011;6: 679-689.
18. Davin JC, Coppo R. Henoch-Schönlein purpura nephritis in children. Nat Rev Nephrol 2014;10:563-573.
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