Incidence of Acute Kidney Injury due to Contrast Usage in Patients Admitted to Mofid Children’s Hospital (2019-2020)
Journal of Pediatric Nephrology,
Vol. 9 No. 2 (2021),
14 April 2021
,
Page 1-6
https://doi.org/10.22037/jpn.v8i2.33082
Abstract
Background and aims: Contrast-induced renal impairment endangers the patients' health and imposes a financial burden on families and the health care system. Therefore, this study was conducted to examine the rate of nephropathy in patients admitted to Mofid Children's Hospital in 2018 and 2019. Methods: In this cross-sectional study serum creatinine was measured at baseline and 48-72 hours after CT -scan an increase of more than 25% in serum creatinine was considered CIN. Paired samplet-test was used to assess the change in the Cr. The research data were analyzed using SPSS-25 software and the significance level in all tests was set at P = 0.001. Results: In this study,180 children underwent contrast-enhanced CT-scan with a mean age of 5.72 years, of whom 81 (45%) were girls and 99 (55%) were boys. The mean baseline creatinine was 0.633 ± 0.137 mg / dl, which increased significantly to 0.675±0.164 mg / dl 48-72 hours after the first measurement. The chance of developing ARF in ciprofloxacin users was 4.86 times higher than patients who did not use this drug. Conclusion: In children underwent CT scan, the incidence of ARF is 17.2%. Ciprofloxacin increases the risk of acute kidney problems by 4.8 times.
Keywords:
- Acute kidney Injury
- Contrast Nephropathy
- Ciprofloxacin
- Child
How to Cite
1.
Esfandiar N, Khalili M, Dalirani R, Nickhoo Z. Incidence of Acute Kidney Injury due to Contrast Usage in Patients Admitted to Mofid Children’s Hospital (2019-2020). J Ped Nephrol [Internet]. 2021 Mar. 31 [cited 2024 Apr. 25];9(2):1-6. Available from: https://journals.sbmu.ac.ir/jpn/article/view/33082
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6. Hossain MA, Costanzo E, Cosentino J, Patel C, Qaisar H, Singh V, Khan T, Cheng JS, Asif A, Vachharajani TJ. Contrast-induced nephropathy: Pathophysiology, risk factors, and prevention. Saudi Journal of Kidney Diseases and Transplantation. 2018 Jan 1;29(1):1.
7. Chertow GM, Burdick E, Honour M, Bonventre JV, Bates DW. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. Journal of the American Society of Nephrology. 2005 Nov 1;16(11):3365-70.
8. Basile DP, Anderson MD, Sutton TA. Pathophysiology of acute kidney injury. Comprehensive Physiology. 2011 Jan;2(2):1303-53.
9. Tanner GA. Experimental models of acute tubular necrosis. InHandbook of animal models of renal failure 2018 Jan 18 (pp. 109-144). CRC Press.
10. Azzalini L, Spagnoli V, Ly HQ. Contrast-induced nephropathy: from pathophysiology to preventive strategies. Canadian Journal of Cardiology. 2016 Feb 1;32(2):247-55.
11. Makris K, Spanou L. Acute kidney injury: definition, pathophysiology and clinical phenotypes. The Clinical Biochemist Reviews. 2016 May;37(2):85.
12. Mitchell AM, Kline JA, Jones AE, Tumlin JA. Major adverse events one year after acute kidney injury after contrast-enhanced computed tomography. Annals of emergency medicine. 2015 Sep 1;66(3):267-74.
13. Iakovou I, Dangas G, Mehran R, Lansky AJ, Ashby DT, Fahy M, Mintz GS, Kent KM, Pichard AD, Satler LF, Stone GW. Impact of gender on the incidence and outcome of contrast-induced nephropathy after percutaneous coronary intervention. The Journal of invasive cardiology. 2003 Jan;15(1):18-22.
14. Nough H, Eghbal F, Soltani M, Nejafi F, Falahzadeh H, Fazel H, Sheikhvatan M. Incidence and main determinants of contrast-induced nephropathy following coronary angiography or subsequent balloon angioplasty. Cardiorenal medicine. 2013;3(2):128-35.
15. El-Hajjar M, Bashir I, Khan M, Min J, Torosoff M, DeLago A. Incidence of contrast-induced nephropathy in patients with chronic renal insufficiency undergoing multidetector computed tomographic angiography treated with preventive measures. The American journal of cardiology. 2008 Aug 1;102(3):353-6.
16. Lee J, Cho JY, Lee HJ, Jeong YY, Kim CK, Park BK, Sung DJ, Kang BC, Jung SI, Lee EJ, Yi BH. Contrast-induced nephropathy in patients undergoing intravenous contrast-enhanced computed tomography in Korea: a multi-institutional study in 101487 patients. Korean journal of radiology. 2014 Aug 1;15(4):456-63.
2. Long TE, Helgadottir S, Helgason D, Sigurdsson GH, Gudbjartsson T, Palsson R, Indridason OS, Sigurdsson MI. Postoperative Acute Kidney Injury: Focus on Renal Recovery Definitions, Kidney Disease Progression and Survival. American journal of nephrology. 2019;49(3):175-85.
3. Stoll T, Bringans S, Winfield K, Casey T, Davis W, Peters K, Davis T, Lipscombe R, inventors; Proteomics International Pty Ltd, assignee. Method for Identifying an Agent for Treating Abnormal Kidney Function. United States patent application US 16/218,777. 2019 Apr 11.
4. Sethi AN, Kohli J, Patel AM, Rudnick MR. CONTRAST-INDUCED NEPHROPATHY. Nephrology Secrets: First South Asia Edition-E-Book. 2018 Aug 23:94.
5. van der Molen AJ, Reimer P, Dekkers IA, Bongartz G, Bellin MF, Bertolotto M, Clement O, Heinz-Peer G, Stacul F, Webb JA, Thomsen HS. Post-contrast acute kidney injury–part 1: definition, clinical features, incidence, role of contrast medium and risk factors. European radiology. 2018 Jul 1;28(7):2845-55.
6. Hossain MA, Costanzo E, Cosentino J, Patel C, Qaisar H, Singh V, Khan T, Cheng JS, Asif A, Vachharajani TJ. Contrast-induced nephropathy: Pathophysiology, risk factors, and prevention. Saudi Journal of Kidney Diseases and Transplantation. 2018 Jan 1;29(1):1.
7. Chertow GM, Burdick E, Honour M, Bonventre JV, Bates DW. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. Journal of the American Society of Nephrology. 2005 Nov 1;16(11):3365-70.
8. Basile DP, Anderson MD, Sutton TA. Pathophysiology of acute kidney injury. Comprehensive Physiology. 2011 Jan;2(2):1303-53.
9. Tanner GA. Experimental models of acute tubular necrosis. InHandbook of animal models of renal failure 2018 Jan 18 (pp. 109-144). CRC Press.
10. Azzalini L, Spagnoli V, Ly HQ. Contrast-induced nephropathy: from pathophysiology to preventive strategies. Canadian Journal of Cardiology. 2016 Feb 1;32(2):247-55.
11. Makris K, Spanou L. Acute kidney injury: definition, pathophysiology and clinical phenotypes. The Clinical Biochemist Reviews. 2016 May;37(2):85.
12. Mitchell AM, Kline JA, Jones AE, Tumlin JA. Major adverse events one year after acute kidney injury after contrast-enhanced computed tomography. Annals of emergency medicine. 2015 Sep 1;66(3):267-74.
13. Iakovou I, Dangas G, Mehran R, Lansky AJ, Ashby DT, Fahy M, Mintz GS, Kent KM, Pichard AD, Satler LF, Stone GW. Impact of gender on the incidence and outcome of contrast-induced nephropathy after percutaneous coronary intervention. The Journal of invasive cardiology. 2003 Jan;15(1):18-22.
14. Nough H, Eghbal F, Soltani M, Nejafi F, Falahzadeh H, Fazel H, Sheikhvatan M. Incidence and main determinants of contrast-induced nephropathy following coronary angiography or subsequent balloon angioplasty. Cardiorenal medicine. 2013;3(2):128-35.
15. El-Hajjar M, Bashir I, Khan M, Min J, Torosoff M, DeLago A. Incidence of contrast-induced nephropathy in patients with chronic renal insufficiency undergoing multidetector computed tomographic angiography treated with preventive measures. The American journal of cardiology. 2008 Aug 1;102(3):353-6.
16. Lee J, Cho JY, Lee HJ, Jeong YY, Kim CK, Park BK, Sung DJ, Kang BC, Jung SI, Lee EJ, Yi BH. Contrast-induced nephropathy in patients undergoing intravenous contrast-enhanced computed tomography in Korea: a multi-institutional study in 101487 patients. Korean journal of radiology. 2014 Aug 1;15(4):456-63.
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