P53 and Nuclear Unrest: Biological Driver’s Suggesting Poor Prognosis in Anaplastic Wilm’s Tumor
Journal of Pediatric Nephrology,
Vol. 8 No. 3 (2020),
20 July 2020
,
Page 1-5
https://doi.org/10.22037/jpn.v8i3.30866
Abstract
In the early era, survival from Wilm’s tumor (WT) was less than 10% compare to today's date which has a 90% chance of survival. Multimodal therapy, enhanced surgical techniques, effective chemotherapy regimens and radiation therapy in treatment protocols have revolutionized the survival rates. As the advancement continues, molecular basis and targeted therapies are being considered for risk stratification and better treatment. Particularly important is evaluation of molecular abnormalities that confer to poor prognosis, so that intensification of chemotherapy and radiotherapy can be done to achieve maximum remission. The aim of this article is to highlight the importance of p53 and a morphological spectrum that have been associated with prognosis in WT.
- WT
- Wilm's tumor
- malignancy
- Child
- Prognosis
How to Cite
References
Pizzo, P.A.; Poplack, D.G.; Adamson, P.C.; Blaney, S.M.; Helman, L. Principles and Practice of Pediatric Oncology, 7th ed.; Wolters Kluwer Health: Philadelphia, PA, USA, 2016.
Faria, P.; Beckwith, J.B.; Mishra, K.; Zuppan, C.; Weeks, D.A.; Breslow, N.; Green, D.M. Focal versus diffuse anaplasia in Wilms tumor—New definitions with prognostic significance: A report from the national Wilms tumor study group. Am. J. Surg. Pathol. 1996, 20, 909–920.
Salama, A., & Kamel, A. (2011). Evaluation of nuclear unrest and p53 immunostaining in Wilms’ tumor. Journal of the Egyptian National Cancer Institute, 23(1), 31–39.
Stiller CA, Parkin DM. International variations in the incidence of childhood renal tumours. Br J Cancer. 1990;62(6):1026-30.
D’Angio GJ. The National Wilms Tumor Study: a 40 year perspective. Life- time Data Anal. 2007;13(4):463-70.
Young MD, Mitchell TJ, Vieira Braga FA, Tran MGB, Stewart BJ, Ferdinand JR, et al. Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors. Science. 2018;361(6402):594-9.
Perlman EJ. Pediatric renal tumors: practical updates for the pathologist. Pediatr Dev Pathol. 2005;8(3):320-3
Salama A1, Kamel A, J Egypt Natl Canc Inst. 2011 Mar;23(1):31-9.
C. Lahoti, P. orner, D. Malkin, and H. Yeger, “Immunohis- tochemical detection of p53 in Wilms’ tumors correlates with unfavorable outcome,” e American Journal of Pathology, vol. 148, no. 5, pp. 1577–1589, 1996.
D. Malkin, E. Sexsmith, H. Yeger, B. R. G. Williams, and M. J. Coppes, “Mutations of the p53 tumor suppressor gene occur infrequently in Wilms’ tumor,” Cancer Research, vol. 54, no. 8, pp. 2077–2079, 1994.
P.L.Cheah,L.M.Looi,andL.L.Chan,“Immunohistochemical expression of p53 proteins in Wilms’ tumour: a possible associ- ation with the histological prognostic parameter of anaplasia,” Histopathology, vol. 28, no. 1, pp. 49–54, 1996.
Significance of TP53 Mutation in Wilms Tumors with Diffuse Anaplasia: A Report from the Children’s Oncology Group ; Clin Cancer Res. 2016 November 15; 22(22): 5582–5591
Zuppan CW, Beckwith JB, Luckey DW. Anaplasia in uni- lateral Wilms’ tumor: a report from the National Wilms’ Tumor Study Pathology Center. Hum Pathol. 1988;19: 1199 –1209.
Hill DA1, Shear TD, Liu T, Billups CA, Singh PK, Dome JS. Clinical and biologic significance of nuclear unrest in Wilms tumor. Cancer. 2003 May 1;97(9):2318-26.
- Abstract Viewed: 252 times
- PDF Downloaded: 239 times