A Review on New Coronavirus Mechanism of Action
Journal of Pediatric Nephrology,
Vol. 8 No. 2 (2020),
2 June 2020
,
Page 1-4
https://doi.org/10.22037/jpn.v8i2.30702
Abstract
The new coronavirus outbreak caused by the severe acute respiratory syndrome coronavirus2 (SARS-CoV2) has resulted in more than 126750 deaths worldwide so far and billions of expenses for the governments. SARS-CoV2, similar to SARS, was transmitted from bats and spread via human to human closed contacts. The virus uses its spike protein to bind to angiotensin-converting enzyme 2 receptors on target cells to replicate. Consequently, it spreads from infected cells to contaminate other cells. The body’s first response toward the virus is to activate the innate immune system, leading to the synthesis of inflammatory mediators. In the next step, the adaptive immune system appears where B lymphocytes produce antibodies specific for the virus, and CD8+ cells kill the infected cells directly. In this article, we try to explain the virus mechanism of action and immune response in detail. Although many questions remain unanswered, we expect this review could help in vaccine and treatment progression,
Keywords: COVID-19; SARS-CoV2; Mechanism; Review.
How to Cite
References
de Wilde AH, Snijder EJ, Kikkert M, van Hemert MJ. Host factors in coronavirus replication. In: Current Topics in Microbiology and Immunology. 2018.
Heugel J, Martin ET, Kuypers J, Englund JA. Coronavirus-associated pneumonia in previously healthy children. Pediatr Infect Dis J. 2007;
Paules CI, Marston HD, Fauci AS. Coronavirus Infections-More Than Just the Common Cold. JAMA - Journal of the American Medical Association. 2020.
Wang C, Horby PW, Hayden FG, Gao GF. A novel coronavirus outbreak of global health concern. The Lancet. 2020.
No Title [Internet]. Available from: https://www.worldometers.info/coronavirus/
Channappanavar R, Perlman S. Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology. Seminars in Immunopathology. 2017.
Xu J, Zhao S, Teng T, Abdalla AE, Zhu W, Xie L, et al. Systematic comparison of two animal-to-human transmitted human coronaviruses: SARS-CoV-2 and SARS-CoV. Viruses. 2020;
Singhal T. A Review of Coronavirus Disease-2019 (COVID-19). Indian Journal of Pediatrics. 2020.
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;
Guan Y, Zheng BJ, He YQ, Liu XL, Zhuang ZX, Cheung CL, et al. Isolation and characterization of viruses related to the SARS coronavirus from animals in Southern China. Science (80- ). 2003;
Poon LLM, Chu DKW, Chan KH, Wong OK, Ellis TM, Leung YHC, et al. Identification of a Novel Coronavirus in Bats. J Virol. 2005;
Hu B, Ge X, Wang L-F, Shi Z. Bat origin of human coronaviruses. Virol J. 2015;
Xiong X, Tortorici MA, Snijder J, Yoshioka C, Walls AC, Li W, et al. Glycan shield and fusion activation of a deltacoronavirus spike glycoprotein fine-tuned for enteric infections. J Virol. 2017;
Baig AM, Khaleeq A, Ali U, Syeda H. Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms. ACS Chem Neurosci. 2020;
Pelkmans L, Helenius A. Insider information: What viruses tell us about endocytosis. Current Opinion in Cell Biology. 2003.
Inoue Y, Tanaka N, Tanaka Y, Inoue S, Morita K, Zhuang M, et al. Clathrin-Dependent Entry of Severe Acute Respiratory Syndrome Coronavirus into Target Cells Expressing ACE2 with the Cytoplasmic Tail Deleted. J Virol. 2007;
Yang N, Shen H-M. Targeting the Endocytic Pathway and Autophagy Process as a Novel Therapeutic Strategy in COVID-19. Int J Biol Sci. 2020;
Wang H, Yang P, Liu K, Guo F, Zhang Y, Zhang G, et al. SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway. Cell Res. 2008;
Zhou P, Yang X Lou, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;
Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Research. 2020.
Zou X, Chen K, Zou J, Han P, Hao J, Han Z. Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. Front Med. 2020;
Xu H, Zhong L, Deng J, Peng J, Dan H, Zeng X, et al. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci. 2020;
Daelemans D, Costes S V., Cho EH, Erwin-Cohen RA, Lockett S, Pavlakis GN. In vivo HIV-1 Rev multimerization in the nucleolus and cytoplasm identified by fluorescence resonance energy transfer. J Biol Chem. 2004;
Masters PS. The Molecular Biology of Coronaviruses. Advances in Virus Research. 2006.
Addi A Ben, Lefort A, Hua X, Libert F, Communi D, Ledent C, et al. Modulation of murine dendritic cell function by adenine nucleotides and adenosine: Involvement of the A2B receptor. Eur J Immunol. 2008;
Chien JY, Hsueh PR, Cheng WC, Yu CJ, Yang PC. Temporal changes in cytokine/chemokine profiles and pulmonary involvement in severe acute respiratory syndrome. Respirology. 2006;
Traggiai E, Becker S, Subbarao K, Kolesnikova L, Uematsu Y, Gismondo MR, et al. An efficient method to make human monoclonal antibodies from memory B cells: Potent neutralization of SARS coronavirus. Nat Med. 2004;
Dong Kim K, Zhao J, Auh S, Yang X, Du P, Tang H, et al. Adaptive immune cells temper initial innate responses. Nat Med. 2007;
Rodrigue-Gervais IG, Labbé K, Dagenais M, Dupaul-Chicoine J, Champagne C, Morizot A, et al. Cellular inhibitor of apoptosis protein cIAP2 protects against pulmonary tissue necrosis during influenza virus infection to promote host survival. Cell Host Microbe. 2014;
Zornetzer GA, Frieman MB, Rosenzweig E, Korth MJ, Page C, Baric RS, et al. Transcriptomic Analysis Reveals a Mechanism for a Prefibrotic Phenotype in STAT1 Knockout Mice during Severe Acute Respiratory Syndrome Coronavirus Infection. J Virol. 2010;
Cameron MJ, Bermejo-Martin JF, Danesh A, Muller MP, Kelvin DJ. Human immunopathogenesis of severe acute respiratory syndrome (SARS). Virus Res. 2008;
Jiang Y, Xu J, Zhou C, Wu Z, Zhong S, Liu J, et al. Characterization of cytokine/chemokine profiles of seven acute respiratory syndrome. Am J Respir Crit Care Med. 2005;
Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020;
Pan Y, Guan H. Imaging changes in patients with 2019-nCov. European Radiology. 2020.
Velavan TP, Meyer CG. The COVID-19 epidemic. Tropical Medicine and International Health. 2020.
Tang B, Wang X, Li Q, Bragazzi NL, Tang S, Xiao Y, et al. Estimation of the Transmission Risk of the 2019-nCoV and Its Implication for Public Health Interventions. J Clin Med. 2020;
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