Evaluation of Antibiotic Resistance in Pediatric Urinary Tract Infection in Shahid Beheshti University Hospitals During 2016-2017
Journal of Pediatric Nephrology,
Vol. 7 No. 4 (2019),
29 December 2019
,
Page 1-4
https://doi.org/10.22037/jpn.v7i4.27623
Abstract
Background and Aim: Urinary tract infection (UTI) is one of the most common and important childhood diseases that may lead to complications such as acute pyelonephritis, renal scaring, and renal failure if not diagnosed and treated properly. The antibiotic resistance rate has increased recently because of unnecessary antibiotic consumption. In order to prescribe an appropriate drug as empirical therapy, it is necessary to know the prevalence of pathogens causing UTI and their antibiotic resistance rate in the community. Therefore, this study was conducted to present an appropriate guideline for UTI empirical therapy through evaluating the rate of antibiotic resistance in a sample of hospitalized patients suffering from UTI.
Methods: This retrospective descriptive analytical study was conducted in 130 children with UTI whose medical records included antibiogram results in hospitals affiliated with Shahid Beheshti University during 2016-2017.
Results: Of 130 patients, 73.07% were girls and 26.92% were boys. About 50% of the patients were under one-year-old, 33.07% were 1-3 years old, and 16.15% were over 3 years old. The detected pathogens were E. coli in 63.07%, Enterococcus in 14.61%, Klebsiella in 13.07%, Pseudomonas aeruginosa in 5.38%, and Enterobacter in 3.84%.
Conclusion: Based on the data of the present study, ampicillin, co-trimoxazole and first-generation cephalosporins are not appropriate for UTI empirical therapy.
Keywords: Antibiogram; Antibiotic resistance; Urinary tract infection.
- Urinary tract infection
- Antibiotic resistance
- Antibiogram.
How to Cite
References
Kliegman R. Nelson textbook of pediatrics. 20th ed2016.
Kliegman R. Nelson essentials of peditrics. 7th ed2015.
urinary tract infections in children:epidemiology and risk factors [Internet]. Available from: https://www.uptodate.com/contents/urinary-tract-infections-in-children-epidemiology-and-risk-factors.
urinary tract infections in infants and children older than one mounth: clinical features and diagnosis [Internet]. Available from: https://www.uptodate.com/contents/urinary-tract-infections-in-infants-and-children-older-than-one-month-clinical-features-and-diagnosis.
Urinary tract infections in infants older than one month and young children: Acute management, imaging, and prognosis [Internet]. Available from: https://www.uptodate.com/contents/urinary-tract-infections-in-infants-older-than-one-month-and-young-children-acute-management-imaging-and-prognosis.
Kliegman R. Radiology Nelson textbook of pediatrics. 16th ed2000.
Bergestein J, MD, Judal U, al e. The urinary system,Nelson textbook of pediatrics: Philadelphia,W.B.Sunders Co
1360-63 p.
Pape L, Gunzer F, Ziesing S, Pape A, Offner G, Ehrich JH. [Bacterial pathogens, resistance patterns and treatment options in community acquired pediatric urinary tract infection]. Klin Padiatr. 2004;216(2):83-6.
Pouladfar G, Basiratnia M, Anvarinejad M, Abbasi P, Amirmoezi F, Zare S. The antibiotic susceptibility patterns of uropathogens among children with urinary tract infection in Shiraz. medicine(Baltimore). 2017;96(37).
Maqale H, Kassim I, Odera S, Omolo M, Jaoko W, Jolly P. ANTIBIOTIC SUSCEPTIBILITY OF ORGANISMS CAUSING URINARY TRACT INFECTION IN PATIENTS PRESENTING AT KENYATTA NATIONAL HOSPITAL, NAIROBI. East Afr Med J. 2015;92(7).
Farajnia S, Alikhani MY, Ghotaslou R, Naghili B, Nakhlband A. Causative agents and antimicrobial susceptibilities of urinary tract infections in the northwest of Iran. Int J Infect Dis. 2009;13(2):140-4.
Yuksel S, Ozturk B, Kavaz A, Ozcakar ZB, Acar B, Guriz H, et al. Antibiotic resistance of urinary tract pathogens and evaluation of empirical treatment in Turkish children with urinary tract infections. Int J Antimicrob Agents. 2006;28(5):413-6.
Rezaee MA, Abdinia B. Etiology and Antimicrobial Susceptibility Pattern of Pathogenic Bacteria in Children Subjected to UTI: A Referral Hospital-Based Study in Northwest of Iran. Medicine (Baltimore). 2015;94(39):e1606.
Kocak M, Buyukkaragoz B, Celebi Tayfur A, Caltik A, Koksoy AY, Cizmeci Z, et al. Causative pathogens and antibiotic resistance in children hospitalized for urinary tract infection. Pediatr Int. 2016;58(6):467-71.
Catal F, Bavbek N, Bayrak O, Karabel M, Karabel D, Odemis E, et al. Antimicrobial resistance patterns of urinary tract pathogens and rationale for empirical therapy in Turkish children for the years 2000-2006. Int Urol Nephrol. 2009;41(4):953-7.
Borsari AG, Bucher B, Brazzola P, Simonetti GD, Dolina M, Bianchetti MG. Susceptibility of Escherichia coli strains isolated from outpatient children with community-acquired urinary tract infection in southern Switzerland. Clin Ther. 2008;30(11):2090-5.
Marzouk M, Ferjani A, Haj Ali M, Boukadida J. [Profile and susceptibility to antibiotics in urinary tract infections in children and newborns from 2012 to 2013: Data from 1879 urine cultures]. Arch Pediatr. 2015;22(5):505-9.
Cullen IM, Manecksha RP, McCullagh E, Ahmad S, O'Kelly F, Flynn R, et al. An 11-year analysis of the prevalent uropathogens and the changing pattern of Escherichia coli antibiotic resistance in 38,530 community urinary tract infections, Dublin 1999-2009. Ir J Med Sci. 2013;182(1):81-9.
Velez Echeverri C, Serna E, LM, Serrano A, Ochoa-Garcia C, Rojas Rosas L, Maria Bodoya A, et al. Resistance profile for pathogens causing urinary tract infection in a pediatric population, and antibiotic treatment response at a university hospital, 2010-2011. Colomb Med(cali). 2014;30,45(1):39-44.
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