Photobiomodulation and Antimicrobial Photodynamic Therapy for Oral Ulcers in a Patient With Thrombocytopenia Following Bone Marrow Transplantation Phototherapies for Oral Ulcers
Journal of Lasers in Medical Sciences,
Vol. 13 (2022),
,
Page e17
Abstract
Introduction: Thrombocytopenia is usually seen after allogeneic hematopoietic stem cell transplantation (HSCT) and may favor the development of oral bleeding, infections, and ulcerations.
Case Report: A patient with chronic myelomonocytic leukemia had been submitted to allogeneic HSCT. Within a few days, she developed severe thrombocytopenia and an extensive ulcerative area comprising both lips, which bled spontaneously, as well as smaller ulcers on the tongue mucosa. The lesions were managed using a combination of phototherapies (photobiomodulation and antimicrobial photodynamic therapies), totalizing 4 laser sessions. After 4 days, there was an important reduction in the severity of the lesions, with spontaneous disappearance of the crusts and reepithelization.
Conclusion: The proposed combination of phototherapies would be a suitable therapeutic modality for the management of oral lesions related to platelet disorders induced by oncologic treatments.
- Photodynamic therapy; Low-level laser; Thrombocytopenia; Oral lesion; Lip diseases.
How to Cite
References
Akahoshi Y, Kanda J, Gomyo A, Hayakawa J, Komiya Y, Harada N, et al. Risk Factors and Impact of Secondary Failure of Platelet Recovery After Allogeneic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2016;22(9):1678-1683. doi:10.1016/j.bbmt.2016.06.003
Akahoshi Y, Kimura SI, Gomyo A, Hayakawa J, Tamaki M, Harada N, et al. Delayed platelet recovery after allogeneic hematopoietic stem cell transplantation: Association with chronic graft-versus-host disease and survival outcome. Hematol Oncol. 2018;36(1):276-284. doi:10.1002/hon.2427
Zhang X, Fu H, Xu L, Liu D, Wang J, Liu K, Huang X. Prolonged Thrombocytopenia Following Allogeneic Hematopoietic Stem Cell Transplantation and Its Association with a Reduction in Ploidy and an Immaturation of Megakaryocytes. Biol Blood Marrow Transplant. 2011;17(2):274-280. doi:10.1016/j. bbmt.2010.09.007
Gomes AOF, Silva Junior A, Noce CW, Ferreira M, Maiolino A, Torres SR. The frequency of oral conditions detected in hematology inpatients. Hematol Transfus Cell Ther. 2018;40(3):240-244. doi:10.1016/j.htct.2018.02.006
Campos L, Rezende SB, Simões A, Palma LF, Tateno RY, da Silva RL, Macedo MC. Photobiomodulation and
photodynamic therapy for the management of oral graftversus-host disease: A case report. Photodiagnosis Photodyn Ther. 2020;30:101776. doi:10.1016/j.pdpdt.2020.101776
Rezende SB, Campos L, Palma LF, Tateno RY, Simões A, Macedo MC, Silva RLD. Photobiomodulation and
antimicrobial photodynamic therapy for oral cytomegalovirus reactivation following acute graft-versus-host disease. Photodiagnosis Photodyn Ther. 2020;32:101849. doi:10.1016/j.pdpdt.2020.101849
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