Low serum vitamin D is associated with failure of Helicobacter pylori treatment
Student Research in Translational Medicine,
Vol. 3 No. 1 (2021),
1 March 2021
,
Page 1-4
https://doi.org/10.22037/smsj.v3i1.33020
Abstract
Background and aims: Helicobacter pylori are the most common gastrointestinal infection worldwide. Determination of contributing factors for successful eradication of Helicobacter pylori is important for better infection control. Therefore, this study was conducted to investigate the association between serum vitamin D deficiency and Helicobacter pylori eradication rate.
Results: The results of this study demonstrated that before-treatment vitamin D level was between 10 and 20 ng/dL in majority of unsuccessful cases (40.4%) and it was more than 30 ng/dL in majority of successful cases (83.7%) showing statistically significant difference (P < 0.001).
Conclusion: This study showed a significant association between vitamin D deficiency and Helicobacter pylori eradication and low vitamin D level resulted in failure of treatment; Hence in unsuccessful cases, assessment of vitamin D level and possible supplementation in those with hypovitaminosis D is recommended.
- Vitamin D Deficiency
- Vitamin D
- Calcitriol
- 1,25-Dihydroxyvitamin D3
- Vitamin D Receptor
- Vitamin D3 Receptor
- Receptor, Calcitriol
- 1,25-Dihydroxyvitamin D3 Receptor
- Helicobacter pylori
- Helicobacter pylori Eradication
- Disease Eradication
- Disease Elimination
- Urea Breath Test
- Body Mass Index
- Case-Control Studies
- Case Comparison Studies
- Case-Compeer Studies
How to Cite
References
Dunn BE, Cohen H and Blaser MJ.Helicobacter pylori.Clin Microbiol Rev.1997;10(4):720-41.
Kalkan IH, Sapmaz F, Güliter S and Atasoy P.Severe gastritis decreases success rate of Helicobacter pylori eradication.Wiener Klinische Wochenschrift.2016;128(9):329-34.
Perez‐Perez GI, Rothenbacher D and Brenner H.Epidemiology of Helicobacter pylori infection.Helicobacter.2004;9:1-6.
Rana R, Wang SL, Li J, Wang Y, Rao Q and Yang C.Helicobacter pylori infection: A recent approach to diagnosis and management.J Biomed.2017;2(1):45-56.
Malfertheiner P, Link A and Selgrad M.Helicobacter pylori: perspectives and time trends.Nature reviews Gastroenterology & hepatology.2014;11(10):628.
Take S, Mizuno M, Ishiki K, Nagahara Y, Yoshida T, Yokota K, et al.The effect of eradicating Helicobacter pylori on the development of gastric cancer in patients with peptic ulcer disease.American Journal of Gastroenterology.2005;100(5):1037-42.
Horikawa C, Kodama S, Fujihara K, Hirasawa R, Yachi Y, Suzuki A, et al.High risk of failing eradication of Helicobacter pylori in patients with diabetes: a meta-analysis.Diabetes research and clinical practice.2014;106(1):81-87.
Suzuki H, Nishizawa T and Hibi T.Helicobacter pylori eradication therapy.Future microbiology.2010;5(4):639-48.
Uotani T, Miftahussurur M and Yamaoka Y.Effect of bacterial and host factors on Helicobacter pylori eradication therapy.Expert opinion on therapeutic targets.2015;19(12):1637-50.
Baeke F, Takiishi T, Korf H, Gysemans C and Mathieu C.Vitamin D: modulator of the immune system.Current opinion in pharmacology.2010;10(4):482-96.
Laaksi I, Ruohola J-P, Tuohimaa P, Auvinen A, Haataja R, Pihlajamäki H, et al.An association of serum vitamin D concentrations< 40 nmol/L with acute respiratory tract infection in young Finnish men.The American journal of clinical nutrition.2007;86(3):714-17.
Nnoaham KE and Clarke A.Low serum vitamin D levels and tuberculosis: a systematic review and meta-analysis.International journal of epidemiology.2008 ;37(1):113-19.
Shalaby SA, Handoka NM and Amin RE.Vitamin D deficiency is associated with urinary tract infection in children.Archives of medical science: AMS.2018;14(1):115.
Thorsen SU, Pipper CB, Skogstrand K, Pociot F and Svensson J.25-Hydroxyvitamin D and peripheral immune mediators: results from two nationwide Danish pediatric cohorts.Nutrients.2017;9(4):365.
Antico A, Tozzoli R, Giavarina D, Tonutti E and Bizzaro N.Hypovitaminosis D as predisposing factor for atrophic type A gastritis: a case–control study and review of the literature on the interaction of vitamin D with the immune system.Clinical reviews in allergy & immunology.2012;42(3):355-64.
Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, et al.Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response.Science.2006;311(5768):1770-73.
Wanibuchi K, Hosoda K, Ihara M, Tajiri K, Sakai Y, Masui H, et al.Indene compounds synthetically derived from vitamin D have selective antibacterial action on Helicobacter pylori.Lipids.2018;53(4):393-401.
de Jesus Martins D, Matos GC, Loiola RS, D’Annibale V and Corvelo T.Relationship of vitamin D receptor gene polymorphisms in Helicobacter pylori gastric patients.Clinical and experimental gastroenterology.2018;11:19.
Guo L, Chen W, Zhu H, Chen Y, Wan X, Yang N, et al.H elicobacter pylori Induces Increased Expression of the Vitamin D Receptor in Immune Responses.Helicobacter.2014;19(1):37-47.
Hosoda K, Shimomura H, Wanibuchi K, Masui H, Amgalanbaatar A, Hayashi S, et al.Identification and characterization of a vitamin D 3 decomposition product bactericidal against Helicobacter pylori.Scientific reports.2015;5:8860.
El Shahawy MS, Hemida MH, El Metwaly I and Shady ZM.The effect of vitamin D deficiency on eradication rates of Helicobacter pylori infection.JGH Open.2018;2(6):270-75.
Huang B, Yan S, Chen C and Ye S.Effect of 25-hydroxyvitamin D on Helicobacter pylori eradication in patients with type 2 diabetes.Wien Klin Wochenschr.2019;131(3-4):75-80.
Yildirim O, Yildirim T, Seckin Y, Osanmaz P, Bilgic Y and Mete R.The influence of vitamin D deficiency on eradication rates of Helicobacter pylori.Advances in Clinical and Experimental Medicine.2017;26(9):1377-81.
Surmeli DM, Surmeli ZG, Bahsi R, Turgut T, Oztorun HS, Atmis V, et al.Vitamin D deficiency and risk of Helicobacter pylori infection in older adults: a cross-sectional study.Aging clinical and experimental research.2019;31(7):985-91.
- Abstract Viewed: 236 times
- PDF Downloaded: 204 times